6 Results for "

Pomalidomide-C3-adavosertib

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "Pomalidomide-C3-adavosertib" in MCE Product Catalog:

Cat. No.: HY-133618
CAS No.: 2414418-49-6
Purity:  99.84%
Target:  

Wee1 PROTACs Apoptosis

Research Areas:  

Cancer

Pomalidomide-C3-adavosertib is a rapid and selective PROTAC Wee1 degrader (IC50=3.58 nM). Pomalidomide-C3-adavosertib shows anti-cancer cell proliferation activity, and induces apoptosis .
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Cat. No.: HY-133702
CAS No.: 643087-19-8
Target:  

PROTAC Linkers

Research Areas:  

Cancer

Aniline-piperazine-C3-NH-Boc (Compound Int-3) is a PROTAC linker, and can be used for synthesis of Pomalidomide-C3-adavosertib (HY-133618) and AZD1775 (HY-10993) (a Wee1 inhibitor) .
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Cat. No.: HY-176363
CAS No.: 2113725-19-0
Research Areas:  

Cancer

Adavosertib-C3-NH-Boc is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for Wee1 (HY-10993) and a PROTAC linker (HY-W011561), which recruits E3 ligases. Adavosertib-C3-NH-Boc can be used for synthesis of PROTAC Pomalidomide-C3-adavosertib (HY-133618) .
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Cat. No.: HY-133703A
CAS No.: 2858813-30-4
Target:  

Wee1

Research Areas:  

Cancer

i-AZD1775 TFA is a Target Protein Ligand-Linker Conjugate that contains a target protein ligand and a PROTAC linker, and can recruit E3 ligases. i-AZD1775 TFA can be used for the synthesis of Pomalidomide-C3-adavosertib (HY-133618). i-AZD1775 TFA is an immobilizable analogue of AZD1775. i-AZD1775 TFA retains the ability to inhibit WEE1 in vitro. i-AZD1775 TFA can be studied in anticancer research .
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Cat. No.: HY-169232
Target:  

PROTACs PD-1/PD-L1

Research Areas:  

Cancer

PCC16 chloride is a dual PROTAC degrader targeting DHHC3 and PD-L1, with a DC50 of 0.103 μM for PD-L1 degradation. PCC16 chloride induces DHHC3 degradation via the ubiquitin-proteasome pathway by recruiting the CRBN E3 ubiquitin ligase (E3 ubiquitin ligase). By targeting DHHC3-which is essential for PD-L1 palmitoylation and membrane stability-PCC16 chloride reduces PD-L1 levels, decreases PD-L1 membrane retention time, and impairs its immunosuppressive function. PCC16 chloride enhances anti-tumor immunity by disrupting PD-L1-mediated immunosuppression. PCC16 chloride can be used in the research of immune checkpoint blockade-resistant cancers .
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Cat. No.: HY-133703
CAS No.: 2101954-45-2
Target:  

Wee1

Research Areas:  

Cancer

AZD1775-C3-NH2 is a Target Protein Ligand-Linker Conjugate that contains a target protein ligand and a PROTAC linker, and can recruit E3 ligases. AZD1775-C3-NH2 can be used for the synthesis of Pomalidomide-C3-adavosertib (HY-133618) .
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