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S-isomer

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55

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2

Isotope-Labeled Compounds

1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-113380
    (S)-β-Aminoisobutyric acid
    1 Publications Verification

    		 Endogenous Metabolite Drug Isomer Apoptosis AMPK Cardiovascular Disease Metabolic Disease Inflammation/Immunology
    (S)-β-Aminoisobutyric acid is an orally active S-isomer of β-Aminoisobutyric acid (HY-W012974). (S)-β-Aminoisobutyric acid can be produced through the catabolism of thymine and valine. (S)-β-Aminoisobutyric acid reduces apoptosis and increases the ratio of p-AMPK. (S)-β-Aminoisobutyric acid has cardioprotective effects. (S)-β-Aminoisobutyric acid is associated with acute aerobic exercise .
    (S)-β-Aminoisobutyric acid
  • HY-15532B
    SCH900776 (S-isomer)

    MK-8776 S-isomer

    		 Drug Isomer Cancer
    SCH900776 S-isomer is the S-isomer of SCH900776. SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase1 (Chk1) with IC50 of 3 nM.
    SCH900776 (S-isomer)
  • HY-114271A
    T3-ATA (S-isomer)

    		Thyroid Hormone Receptor Endocrinology
    T3-ATA S-isomer is the S-isomer of T3-ATA, which is the active form of the thyroid hormone.
    T3-ATA (S-isomer)
  • HY-103641A
    (2S)-Octyl-α-hydroxyglutarate
    2 Publications Verification

    (2S)-Octyl-2-HG

    		 Drug Isomer Cancer
    (2S)-Octyl-α-hydroxyglutarate ((2S)-Octyl-2-HG) is a modified form of S-isomer 2-Hydroxyglutarate.
    (2S)-Octyl-α-hydroxyglutarate
  • HY-75095
    (S)-(-)-1-Phenylethanamine

    S-(-)-α-Phenylethylamine; L-(-)-α-Methylbenzylamine

    		 Drug Intermediate Biochemical Assay Reagents Neurological Disease
    (S)-(-)-1-Phenylethanamine (S-(-)-α-Phenylethylamine; L-(-)-α-Methylbenzylamine) is a S-isomer of 1-Phenylethanamine (HY-W012848). (S)-(-)-1-Phenylethanamine can be used as a pharmaceutical intermediate for the synthesis of various active compounds .
    (S)-(-)-1-Phenylethanamine
  • HY-126068
    Esamisulpride

    (S)-Amisulpride; (S)-Aramisulpride; (S)-DAN 2163

    		 Dopamine Receptor 5-HT Receptor Neurological Disease
    Esamisulpride ((S)-Amisulpride) is the S-isomer of Amisulpride (HY-14545). Esamisulpride is a potent dopamine D2/D3 receptor antagonist with Ki values of 4.43 nM for D2R and 0.72 nM for D3R. Esamisulpride is a 5-HT7 receptor antagonist with a Ki of 900 nM. Esamisulpride can be used in the research of schizophrenia and depression .
    Esamisulpride
  • HY-Y0982
    (S)-BINAP

    		Biochemical Assay Reagents Cancer
    (S)-BINAP is the S-isomer of BINAP (HY-Y0003). BINAP is a chiral bisphosphine ligand. (S)-BINAP can be used to assist in the synthesis of compounds with anticancer activity .
    (S)-BINAP
  • HY-126028A
    (+)-Sotalol

    (S)-Sotalol

    		 Adrenergic Receptor Cardiovascular Disease Neurological Disease
    (+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle .
    (+)-Sotalol
  • HY-111540B
    (S)-LY-3381916
    1 Publications Verification

    (S)-IDO1-IN-5

    		 Indoleamine 2,3-Dioxygenase (IDO) Cancer
    (S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ . LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .
    (S)-LY-3381916
  • HY-W674436
    (S)-Thalidomide-4-OH

    		Drug Isomer Cancer
    (S)-Thalidomide-4-OH is the S-isomer of Thalidomide-4-OH (HY-103596). Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs .
    (S)-Thalidomide-4-OH
  • HY-120039A
    (S)-MDL-101146

    		Elastase Inflammation/Immunology
    (S)-MDL-101146 is the S-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis .
    (S)-MDL-101146
  • HY-162002A
    (S)-WSD0628

    		ATM/ATR Cancer
    (S)-WSD0628 (Compound 28) is the S-isomer of WSD0628 (HY-162002). (S)-WSD0628 is the inhibitor for ATM that inhibits the phosphorylation of ATM in MCF-7 cell with IC50 <100 nM. (S)-WSD0628 exhibits radiosensitizing activity. (S)-WSD0628 can cross blood-brain barrier .
    (S)-WSD0628
  • HY-114272A
    T4-ATA (S-isomer)

    		Thyroid Hormone Receptor Endocrinology
    T4-ATA S-isomer is the S-isomer of T4-ATA, which is the active form of the thyroid hormone.
    T4-ATA (S-isomer)
  • HY-105084A
    Lubeluzole dihydrochloride

    		Sodium Channel Calcium Channel Cardiovascular Disease Infection Neurological Disease Cancer
    Lubeluzole dihydrochloride is the dihydrochloride salt of Lubeluzole (HY-105084). Lubeluzole dihydrochloride is the S-isomer of benzothiazole derivative. Lubeluzole dihydrochloride can inhibit glutamate release, glutamate-activated NO synthesis and block voltage-gated Sodium Channel and Calcium Channel. Lubeluzole dihydrochloride exhibits anti-ischemic and neuroprotective effects. Lubeluzole dihydrochloride also shows anti-bacterial and anti-diarrheal potential. Lubeluzole dihydrochloride can inhibit cardiac sodium channel and prolong cardiac action potential. Lubeluzole dihydrochloride can inhibit cancer cells proliferation and invasion and shows chemosensitizing effect. Lubeluzole dihydrochloride can be used for the researches of cancer, infection, neurological and cardiovascular disease such as stroke, infectious diarrhea and ovarian .
    Lubeluzole dihydrochloride
  • HY-112371
    (S)-CR8

    		CDK Cancer
    (S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selective CDK inhibitor with IC50s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC50 0.40 μM) .
    (S)-CR8
  • HY-W093104
    (S)-(-)-2-Methylbutanol

    (S)-2-Methyl-1-butanol

    		 Endogenous Metabolite Others
    (S)-(-)-2-Methylbutanol is a S-isomer of 2-Methylbutanol .
    (S)-(-)-2-Methylbutanol
  • HY-19487A
    Ribocil B

    Ribocil S enantiomer; ent-Ribocil A

    		 Bacterial Infection
    Ribocil-B is the active S-isomer of ribocil which can inhibit flavin mononucleotide (FMN) with a KD of 6.6 nM.
    Ribocil B
  • HY-103035
    BIO-32546

    		Phosphodiesterase (PDE) Cancer
    BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator (IC50: 1 nM), extracted from the patent US20170158687A1 .
    BIO-32546
  • HY-105084
    Lubeluzole

    		Sodium Channel Calcium Channel Infection Cardiovascular Disease Neurological Disease Cancer
    Lubeluzole is the S-isomer of benzothiazole derivative. Lubeluzole can inhibit glutamate release, glutamate-activated NO synthesis and block voltage-gated Sodium Channel and Calcium Channel. Lubeluzole exhibits anti-ischemic and neuroprotective effects. Lubeluzole also shows anti-bacterial and anti-diarrheal potential. Lubeluzole can inhibit cardiac sodium channel and prolong cardiac action potential. Lubeluzole can inhibit cancer cells proliferation and invasion and shows chemosensitizing effect. Lubeluzole can be used for the researches of cancer, infection, neurological and cardiovascular disease such as stroke, infectious diarrhea and ovarian .
    Lubeluzole
  • HY-179783A
    18:0 Dibromo MG (S-isomer)

    		Biochemical Assay Reagents Metabolic Disease
    18:0 Dibromo MG (S-isomer) acts as a detergent for crystallization.
    18:0 Dibromo MG (S-isomer)
  • HY-14664B
    (3R,5S)-Fluvastatin

    (3R,5S)-XU 62-320 free acid

    		 HMG-CoA Reductase (HMGCR) Autophagy Cardiovascular Disease Cancer
    (3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .
    (3R,5S)-Fluvastatin
  • HY-143921S
    Almorexant (αS,1S) isomer-13C,d3

    		Isotope-Labeled Compounds Others
    Almorexant (αS,1S) isomer- 13C,d3 is the 13C- and deuterium labeled Almorexant (αS,1S) isomer .
    Almorexant (αS,1S) isomer-13C,d3
  • HY-114552
    (S)-Dabelotine

    		Adrenergic Receptor Neurological Disease
    (S)-Dabelotine is the S-isomer of Dabelotine and serves as an adrenergic agonist in the investigation of dementia.
    (S)-Dabelotine
  • HY-167168
    (S)-Azelnidipine

    		Calcium Channel Cardiovascular Disease
    (S)-Azelnidipine is a calcium channel (Calcium Channel) blocker and the S-isomer of Azelnidipine, with potential for use in cardiovascular disease research .
    (S)-Azelnidipine
  • HY-112895A
    (R)-UT-155

    		Androgen Receptor Cancer
    (R)-UT-155 (compound 11) is a selective androgen receptor degrader (SARD) ligand. Less active than the S-isomer .
    (R)-UT-155
  • HY-12993A
    RSV604 racemate

    A-60444 racemate

    		 RSV Others
    RSV604 (A-60444) racemate is a racemic mixture, shows less potency against strains of respiratory syncytial virus (RSV) than the S-isomer.
    RSV604 racemate
  • HY-105109B
    (S)-Cilansetron

    		5-HT Receptor Neurological Disease
    (S)-Cilansetron is the S-isomer of Cilansetron. Cilansetron is a 5-HT3 receptor antagonist that can be used in research related to irritable bowel syndrome .
    (S)-Cilansetron
  • HY-129436
    (S)-Bucindolol

    		Adrenergic Receptor Cardiovascular Disease
    (S)-Bucindolol is the (S)-isomer of Bucindolol (HY-103214), a β1-adrenergic receptor blocker. (S)-Bucindolol can be utilized in research on cardiac failure .
    (S)-Bucindolol
  • HY-163529A
    (S)-HN0037

    		HSV Infection
    (S)-HN0037 is the (S)-isomer of HN0037 (HY-163529), a selective and orally active helicase-primase inhibitor that inhibits HSV replication by targeting the viral helicase-primase enzyme complex .
    (S)-HN0037
  • HY-168776
    (S)-C12-200

    		Biochemical Assay Reagents Others
    (S)-C12-200 is the (S)-isomer of C12-200 (HY-145405), an ionizable cationic lipid and helper lipid. (S)-C12-200 can be utilized in the formation of lipid nanoparticles and mRNA delivery .
    (S)-C12-200
  • HY-114061
    (R)-FTY 720P

    		LPL Receptor Others
    (R)-FTY 720P is the R-isomer of FTY 720P. (R)-FTY 720P has less potent binding affinities to S1P1,3,4,5 than (S)-Isomer (HY-15382) .
    (R)-FTY 720P
  • HY-139124
    15(R)-15-Methyl Prostaglandin F2α

    15(R)-Carboprost; 15(R)-15-methyl PGF2α

    		 Prostaglandin Receptor Metabolic Disease
    15(R)-15-Methyl Prostaglandin F2α (15(R)-Carboprost; 15(R)-15-methyl PGF2α) is a metabolically stable analog of PGF2α. 15(R)-15-Methyl Prostaglandin F2α is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-Methyl Prostaglandin F2α converts it into the active 15(S)-isomer. The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.
    15(R)-15-Methyl Prostaglandin F2α
  • HY-103641AS1
    (2R)-Octyl-α-hydroxyglutarate-d17

    (2R)-Octyl-2-HG-d17

    		 Isotope-Labeled Compounds Others Cancer
    (2R)-Octyl-α-hydroxyglutarate-d17 ((2R)-Octyl-2-HG-d17) is deuterium labeled (2R)-Octyl-α-hydroxyglutarate (HY-103641). (2R)-Octyl-α-hydroxyglutarate is a modified form of S-isomer 2-Hydroxyglutarate .
    (2R)-Octyl-α-hydroxyglutarate-d17
  • HY-14664F
    (3R,5S)-Fluvastatin sodium

    (3R,5S)-XU 62-320

    		 HMG-CoA Reductase (HMGCR) Autophagy Cancer
    (3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway .
    (3R,5S)-Fluvastatin sodium
  • HY-169780
    (S)-AMG-628

    		TRP Channel Neurological Disease Inflammation/Immunology
    (S)-AMG-628 (Compound 16q) is the S-isomer of AMG-628 (HY-123374). (S)-AMG-628 is the orally active antagonist for TRPV1, that inhibits the Capsaicin (HY-10448)- and acid-induced Ca 2+-influx with IC50 of 7 nM and 5 nM in CHO cell. (S)-AMG-628 ameliorates Capsaicin-induced rats flinching, and reverses the thermal hypersensitivity in CFA-(HY-153808) induced inflammatory pain models .
    (S)-AMG-628
  • HY-162495A
    (S)-IDOR-1117-2520

    		Drug Isomer CCR Calcium Channel Arrestin P-glycoprotein Inflammation/Immunology
    (S)-IDOR-1117-2520 is the S-isomer of IDOR-1117-2520 (HY-162495). IDOR-1117-2520 is an orally active, potent, selective and reversible CCR6 antagonist. IDOR-1117-2520 antagonizes the CCL20-mediated calcium flow (IC50 = 63 nM) and inhibits β-arrestin recruitment to human CCR6 (IC50 = 30 nM) in cells expressing recombinant human CCR6. IDOR-1117-2520 is found to be a substrate of P-gp/MDR1. IDOR-1117-2520 can be used in the research of autoimmune diseases and skin inflammation .
    (S)-IDOR-1117-2520
  • HY-121535
    Levosemotiadil

    		Sodium Channel Calcium Channel Others
    Levosemotiadil, an S-isomer of semotiadil, exhibits stronger binding affinity to human serum albumin (HSA) compared to its R-isomer counterpart. This study utilized high-performance frontal analysis (HPFA) to demonstrate that levosemotiadil binds approximately three times more strongly to HSA than semotiadil. The binding parameters were evaluated using Scatchard analysis, revealing specific interactions with the diazepam binding site on HSA. The presence of diazepam decreased the binding affinity of both enantiomers, while warfarin did not alter their binding characteristics. These findings highlight levosemotiadil's potential as a Ca- and Na-channel blocker with significant binding preferences for HSA, crucial for understanding its pharmacokinetics and therapeutic effects .
    Levosemotiadil
  • HY-113943
    9(S)-HETE

    		Endogenous Metabolite Others
    9(S)-HETE is the S isomer of 9-HETE (HY-113943A). 9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .
    9(S)-HETE
  • HY-101339A
    (R)-RS 56812 hydrochloride

    		5-HT Receptor Others
    (R)-RS 56812 hydrochloride is a 5-HT3 receptor antagonist that enhances performance in monkeys on a delayed matching task. The (R) isomer produces more systematic improvements than the (S) isomer and has potential inhibitory effects in diseases involving cognitive decline.
    (R)-RS 56812 hydrochloride
  • HY-101339
    (R)-RS 56812

    		Others Others
    (R)-RS 56812 is a 5-HT3 receptor antagonist that enhances performance in monkeys on a delayed matching task. The (R) isomer produces more systematic improvements than the (S) isomer and has potential inhibitory effects in diseases involving cognitive decline.
    (R)-RS 56812
  • HY-117044A
    (±)12-HEPE

    		Prostaglandin Receptor Metabolic Disease
    (±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 μM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s=8.6-8.8 μM).
    (±)12-HEPE
  • HY-N7801
    (±)5-HEPE

    		Drug Isomer Metabolic Disease
    (±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
    (±)5-HEPE
  • HY-Z19668
    Edoxaban impurity 12

    Edoxaban cyclohexane ethyl ester (S,S,S)-isomer

    		 Drug Intermediate Others
    Edoxaban impurity 12 (Edoxaban cyclohexane ethyl ester (S,S,S)-isomer) is an impurity of Edoxaban.
    Edoxaban impurity 12
  • HY-B0280A
    (S)-Ranolazine

    (S)-CVT 303; (S)-RS 43285-003

    		 Drug Isomer Cardiovascular Disease
    (S)-Ranolazine is the S-isomer of Ranolazine (HY-B0280). Ranolazine is an antianginal agent .
    (S)-Ranolazine
  • HY-E71119
    (S)-Coclaurine-N-methyltransferase

    		Biochemical Assay Reagents Others
    (S)-Coclaurine-N-methyltransferase (EC 2.1.1.140) is specific for the (S)-isomer of coclaurine. Norcoclaurine can also act as an acceptor.
    (S)-Coclaurine-N-methyltransferase
  • HY-172938
    C24 (2'(S)-Hydroxy) dihydro ceramide (d18:0/24:0)

    		Drug Isomer Others
    C24 (2'(S)-Hydroxy) dihydro ceramide (d18:0/24:0) is the 2S-isomer of C24 Dihydro ceramide (d18:0/24:0) (HY-156206) and the S-isomer of C24 (2'(R)-Hydroxy) dihydro ceramide (d18:0/24:0) (HY-158952).
    C24 (2'(S)-Hydroxy) dihydro ceramide (d18:0/24:0)
  • HY-153130
    (S)-Zadavotide guraxetan

    (S)-PSMA I&T; (S)-PNT-2002

    		 Drug Isomer PSMA Cancer
    (S)-Zadavotide guraxetan ((S)-PSMA I&T) is the S-isomer of EuK-Sub-kf-iodo-y-DOTAGA. (S)-Zadavotide guraxetan is a PSMA targeting compound .
    (S)-Zadavotide guraxetan
  • HY-156438A
    (S)-Ruvonoflast

    (S)-NT-0796

    		 Drug Isomer Neurological Disease
    (S)-Ruvonoflast ((S)-NT-0796) is the S-isomer of Ruvonoflast (HY-156438). Ruvonoflast (NT-0796) is an orally active, selective, centrally nervous system-transporting NLRP3 inflammasome inhibitor .
    (S)-Ruvonoflast
  • HY-118572
    (S)-Allantoin

    		Drug Isomer Others
    (S)-Allantoin is the S-isomer of Allantoin (HY-N0543). (S)-Allantoin binds selectively in the active site of urate oxidase. (S)-Allantoin can be converted to Allantoate by the action of allantoicase. (S)-Allantoin serves as a source of nitrogen in Arabidopsis thaliana .
    (S)-Allantoin
  • HY-103035R
    BIO-32546 (Standard)

    		Reference Standards Phosphodiesterase (PDE) Cancer
    BIO-32546 (Standard) is the analytical standard of BIO-32546 (HY-103035). This product is intended for research and analytical applications. BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator (IC50: 1 nM), extracted from the patent US20170158687A1 .
    BIO-32546 (Standard)

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