30236-32-9
30236-32-9
Chemical Structure
(+)-Sotalol
Synonym(s): (S)-Sotalol
- CAS No.: 30236-32-9
- Formula:C12H20N2O3S
- Molecular Weight:272.36
InChIKey: ZBMZVLHSJCTVON-GFCCVEGCSA-N
SMILES: CC(C)NC[C@H](C1=CC=C(C=C1)NS(C)(=O)=O)O
Biological Activity: (+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(+)-Sotalol | 99.89% | (+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle. | ||||||||||||||||||||
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References
- [1]. ChuanjunLu, et al. The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol. Tetrahedron: Asymmetry.Volume 22, Issue 7.11 April 2011, Pages 722-727
- [2]. Kato R, et al. Electrophysiologic effects of the levo- and dextrorotatory isomers of sotalol in isolated cardiac muscle and their in vivo pharmacokinetics. J Am Coll Cardiol. 1986 Jan;7(1):116-25. [Content Brief]
- [3]. Lynch JJ, et al. Antiarrhythmic and antifibrillatory actions of the levo- and dextrorotatory isomers of sotalol. J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1132-41. [Content Brief]
