1084893-56-0
1084893-56-0
Chemical Structure
(S)-CR8
- CAS No.: 1084893-56-0
- Formula:C24H29N7O
- Molecular Weight:431.53
IUPAC Name: (S)-2-((9-isopropyl-6-((4-(pyridin-2-yl)benzyl)amino)-9H-purin-2-yl)amino)butan-1-ol
InChIKey: HOCBJBNQIQQQGT-IBGZPJMESA-N
SMILES: CC[C@H](NC1=NC(NCC2=CC=C(C3=NC=CC=C3)C=C2)=C4N=CN(C(C)C)C4=N1)CO
Biological Activity: (S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selective CDK inhibitor with IC50s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC50 0.40 μM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S)-CR8 | 99.0% | (S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selective CDK inhibitor with IC50s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC50 0.40 μM). | ||||||||||||||||||||
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References
Keywords
