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Results for "

SF1

" in MedChemExpress (MCE) Product Catalog:

31

Inhibitors & Agonists

2

Inhibitory Antibodies

3

Recombinant Proteins

2

Isotope-Labeled Compounds

5

Antibodies

9

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0627
    Metformin
    Maximum Cited Publications
    196 Publications Verification

    1,1-Dimethylbiguanide

    AMPK Autophagy Mitophagy Apoptosis mTOR Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo [1] .
    Metformin
  • HY-17471A
    Metformin hydrochloride
    Maximum Cited Publications
    196 Publications Verification

    1,1-Dimethylbiguanide hydrochloride

    AMPK Autophagy Mitophagy Apoptosis mTOR Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo [1] .
    Metformin hydrochloride
  • HY-115613
    ML-180
    5 Publications Verification

    SR1848

    Orphan Nuclear Receptor Cancer
    ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers [1] .
    ML-180
  • HY-131445
    RJW100
    1 Publications Verification

    MicroRNA Endocrinology Cancer
    RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively [1]. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter .
    RJW100
  • HY-17471AR

    1,1-Dimethylbiguanide hydrochloride (Standard)

    Reference Standards AMPK Autophagy Mitophagy Apoptosis mTOR Cardiovascular Disease Metabolic Disease Cancer
    Metformin hydrochloride (Standard) is the analytical standard of Metformin hydrochloride (HY-17471A). This product is intended for research and analytical applications. Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo [1] .
    Metformin hydrochloride (Standard)
  • HY-134462

    Orphan Nuclear Receptor Metabolic Disease Cancer
    RJW103 is an acid-stable SF-1 (NR5A1) and LRH-1 agonist with pEC50 values of 6.5 and 5.9, respectively. RJW103 activates SF-1- and LRH-1-mediated transcription of endogenous target genes. RJW103 can be used in research on cancer, endocrinology and metabolic diseases, such as adrenocortical tumors [1] .
    RJW103
  • HY-107404

    Orphan Nuclear Receptor Endocrinology
    SID 7969543 is a selective SF-1 (steroidogenic factor 1, NR5A1) inhibitor with an IC50 of 760 nM. SID 7969543 inhibits SF-1-triggered luciferase expression with IC50 of 30 nM. SF-1 is a transcription factor belonging to the nuclear receptor superfamily [1] .
    SID 7969543
  • HY-148259

    Orphan Nuclear Receptor Cancer
    SF-1 antagonist-1 (compound 11) is a antagonist of steroidogenic factor 1 (SF-1). SF-1 antagonist-1 affects SF-1 transcriptional activity with an EC50 value of <200 nM. SF-1 antagonist-1 inhibits the proliferation of Rat Leydig tumor cells. SF-1 antagonist-1 can be used for the research of cancer [1].
    SF-1 antagonist-1
  • HY-131445B
    RR-RJW100
    1 Publications Verification

    Orphan Nuclear Receptor Metabolic Disease
    RR-RJW100, the enantiomer of RJW100, is an nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1) agonist. RJW100 can be synthesized as two enantiomers, RR-RJW100 and SS-RJW100, with RR-RJW100 shown to be the more potent LRH-1 agonist. RR-RJW100 is involved in the regulation of metabolic homeostasis and is used in studies of diabetes, liver disease and inflammatory bowel disease [1] .
    RR-RJW100
  • HY-153736

    DNA/RNA Synthesis Cancer
    NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations [1].
    NSC 194308
  • HY-B0627S

    1,1-Dimethylbiguanide-d6

    Isotope-Labeled Compounds AMPK Autophagy Mitophagy Apoptosis mTOR Cardiovascular Disease Cancer
    Metformin-d6 (1,1-Dimethylbiguanide-d6) is a deuterated labeled Metformin (HY-B0627). Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo [1] .
    Metformin-d6
  • HY-134462A

    Orphan Nuclear Receptor Cancer
    RJW103 TFA is an acid-stable SF-1 (NR5A1) and LRH-1 agonist with pEC50 values of 6.5 and 5.9, respectively. RJW103 TFA activates SF-1- and LRH-1-mediated transcription of endogenous target genes. RJW103 TFA can be used in research on cancer, endocrinology and metabolic diseases, such as adrenocortical tumors [1] .
    RJW103 TFA
  • HY-P991187

    AGX-101 Antibody

    Transmembrane Glycoprotein Cancer
    Anti-TM4SF1 Antibody (AGX-A07) is a humanized IgG1 monoclonal antibody that targets TM4SF1. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-TM4SF1 Antibody (AGX-A07)
  • HY-RS12756

    Small Interfering RNA (siRNA) Others

    SF1 Human Pre-designed siRNA Set A contains three designed siRNAs for SF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SF1 Human Pre-designed siRNA Set A
    SF1 Human Pre-designed siRNA Set A
  • HY-129359

    ADC Linker Cancer
    PDP-Pfp is a reducible ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) [1].
    PDP-Pfp
  • HY-128207

    Orphan Nuclear Receptor Cancer
    SID7970631, as an isoquinolinone analog, is a potent and selective submicromolar SF-1 inhibitor (IC50=255 nM). SID7970631 can be used for the research of cancer [1] .
    SID7970631
  • HY-RS23319

    Small Interfering RNA (siRNA) Others

    Sf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sf1 Rat Pre-designed siRNA Set A
    Sf1 Rat Pre-designed siRNA Set A
  • HY-RS16877

    Small Interfering RNA (siRNA) Others

    Sf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sf1 Mouse Pre-designed siRNA Set A
    Sf1 Mouse Pre-designed siRNA Set A
  • HY-B0627A

    1,1-Dimethylbiguanide (glycinate)

    AMPK Autophagy Mitophagy Apoptosis mTOR Cardiovascular Disease Metabolic Disease Cancer
    Metformin (1,1-Dimethylbiguanide) glycinate inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin glycinate exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin glycinate also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin glycinate regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo [1] .
    Metformin (glycinate)
  • HY-B0627S1

    1,1-Dimethylbiguanide-13C2 hydrochloride

    Isotope-Labeled Compounds AMPK Autophagy Mitophagy Apoptosis mTOR Cardiovascular Disease Metabolic Disease Cancer
    Metformin- 13C2 (1,1-Dimethylbiguanide- 13C2) hydrochloride is the 13C-labeled Metformin hydrochloride (HY-17471A). Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo [1] .
    Metformin-13C2 hydrochloride
  • HY-155168

    Orphan Nuclear Receptor Cancer
    Iso-RJW100 (compound 24-endo) is a dual-liver receptor homologue-1 (LRH-1) and steroidogenic factor-1 (SF-1) agonist with pEC50 of 6.4 and 7.2, respectively [1].
    Iso-RJW100
  • HY-129372

    ADC Linker Cancer
    PDdB-Pfp is a cleavable ADC linker used for the agents that target for the extracellular loop 1 (ECL1) of TM4SF1 (transmembrane 4 L6 family member 1) [1].
    PDdB-Pfp
  • HY-131445A

    Orphan Nuclear Receptor Metabolic Disease Inflammation/Immunology
    SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability [1] .
    SS-RJW100
  • HY-107404R

    Reference Standards Orphan Nuclear Receptor Endocrinology
    SID 7969543 (Standard) is the analytical standard of SID 7969543 (HY-107404). This product is intended for research and analytical applications. SID 7969543 is a selective SF-1 (steroidogenic factor 1, NR5A1) inhibitor with an IC50 of 760 nM. SID 7969543 inhibits SF-1-triggered luciferase expression with IC50 of 30 nM. SF-1 is a transcription factor belonging to the nuclear receptor superfamily [1] .
    SID 7969543 (Standard)
  • HY-RS14606

    Small Interfering RNA (siRNA) Others

    TM4SF1 Human Pre-designed siRNA Set A contains three designed siRNAs for TM4SF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TM4SF1 Human Pre-designed siRNA Set A
    TM4SF1 Human Pre-designed siRNA Set A
  • HY-RS09553

    Small Interfering RNA (siRNA) Others

    NR5A1 Human Pre-designed siRNA Set A contains three designed siRNAs for NR5A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NR5A1 Human Pre-designed siRNA Set A
    NR5A1 Human Pre-designed siRNA Set A
  • HY-RS26317

    Small Interfering RNA (siRNA) Others

    Tm4sf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tm4sf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tm4sf1 Rat Pre-designed siRNA Set A
    Tm4sf1 Rat Pre-designed siRNA Set A
  • HY-RS19821

    Small Interfering RNA (siRNA) Others

    Tm4sf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tm4sf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Tm4sf1 Mouse Pre-designed siRNA Set A
    Tm4sf1 Mouse Pre-designed siRNA Set A
  • HY-RS17509

    Small Interfering RNA (siRNA) Others

    Nr5a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nr5a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nr5a1 Mouse Pre-designed siRNA Set A
    Nr5a1 Mouse Pre-designed siRNA Set A
  • HY-RS23966

    Small Interfering RNA (siRNA) Others

    Nr5a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nr5a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nr5a1 Rat Pre-designed siRNA Set A
    Nr5a1 Rat Pre-designed siRNA Set A
  • HY-167960

    Drug-Linker Conjugates for ADC Cancer
    BrAc-Galactose-Sar-N-Me-alanine-DM1 (compound 11) is a drug-linker conjugate for ADC, which can be conjugated with the anti-TM4SF1 antibody (e.g., AGX-A07 (HY-P991187) for the synthesis of ADC [1].
    BrAc-Galactose-Sar-N-Me-alanine-DM1

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