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Sieb

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By Targets:	Apoptosis (1) Bacterial (2) Bcl-2 Family (1) Cannabinoid Receptor (1) Carboxypeptidase (1) Drug Derivative (1) Drug Isomer (1) Fungal (2) HIF/HIF Prolyl-Hydroxylase (1) Integrin (1) NF-κB (1) NO Synthase (1) Notch (1) Parasite (1) Phosphatase (1) Reference Standards (1) TNF Receptor (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Infection (3) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (1)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0263

Toosendanin Maximum Cited Publications 6 Publications Verification	Others	Inflammation/Immunology
Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .

HY-N5112B

β,β-Dimethylacrylshikonin 1 Publications Verification Isoarnebin I	HIF/HIF Prolyl-Hydroxylase Apoptosis Notch NO Synthase Bcl-2 Family	Cancer
β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β,β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β,β-Dimethylacrylshikonin inhibits Notch-1 activation. β,β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth .

HY-N8903

Mumefural	Integrin NF-κB Toll-like Receptor (TLR) TNF Receptor	Cardiovascular Disease Neurological Disease
Mumefural is a bioactive component of the processed fruit of Prunus mume Sieb. Mumefural inhibits platelet aggregation. Mumefural shows anti-thrombotic effects and ameliorates cognitive impairment .

HY-N2394

Emodin-1-O-β-D-glucopyranoside 1 Publications Verification	Bacterial	Inflammation/Immunology
Emodin-1-O-β-D-glucopyranoside, isolated from medicinal plant Polygonum cuspidatum Sieb. & Zucc, is a potent and noncompetitive bacterial neuraminidase (BNA) inhibitor with an IC₅₀ of 0.85 μM .

HY-N2247

Guaiacin	Phosphatase	Metabolic Disease
Guaiacin is a arylnaphthalene type lignin isolated from the barks of Machilus thunbergii SIEB. et ZUCC (Lauraceae). Guaiacin significantly increases alkaline phosphatase activity and osteoblast differentiation .

HY-N16123

Chloranthalactone C	Parasite	Infection
Chloranthalactone C (Compound 43), a lindenane-type sesquiterpenoid, is an antimalarial agent. Chloranthalactone C can be isolated from plant Chloranthus japonicas Sieb. Chloranthalactone C inhibits Chloroquine (HY-17589A)-resistant Plasmodium falciparum strain Dd2 growth. Chloranthalactone C can be used for parasitic infections research .

HY-N6930

Shikonofuran A	Others	Metabolic Disease
Shikonofuran A is a natural product isolated from the root of Lithosperraum erythrorhizon Sieb.

HY-122960

Epifriedelanol acetate	Cannabinoid Receptor	Others
Epifriedelanol acetate (Compound Ⅲc) is a nature product. Epifriedelanol acetate can be isolated from Pachysandra terminalis Sieb .

HY-107237

Broussonetine A	Others	Others
Broussonetine A is a pyrrolidine alkaloid compound isolated from the branches of Broussonetia kazinoki Sieb .

HY-N8292

7-(2'-Deoxyadenosin-N6-yl)aristolactam I	Others	Others
7-(2'-Deoxyadenosin-N6-yl)aristolactam I is a Alkaloids product that can be isolated from the herbs of Aristolochia debilis Sieb. et Zucc .

HY-N1300

Shizukanolide F	Fungal	Infection Cancer
Shizukanolide F is a dimeric sesquiterpene, which is derivated from Chloranthus japonicus Sieb. Shizukanolide F exhibits potent antifungal activities against various plant pathogenic fungi and anti-metastasis breast cancer .

HY-N0263R

Toosendanin (Standard)	Reference Standards Others	Inflammation/Immunology
Toosendanin (Standard) is the analytical standard of Toosendanin. This product is intended for research and analytical applications. Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .

HY-N18044

Toosendanal	Drug Derivative	Others
Toosendanal is a limonoid compound present in the fruits of Melia toosendan Sieb. et al. .

HY-N11030

Futoamide	Others	Others
Futoamide is an active compound. Futoamide can be isolated from Piper futokadzura SIEB. et ZUCC .

HY-N8298

Taxezopidine L	Others	Others
Taxezopidine L is a Diterpenoids product that can be isolated from the seeds of the Japanese yew Taxus cuspidata Sieb. et Zucc. .

HY-N8919

N-trans-Sinapoyltyramine	Others	Others
N-trans-Sinapoyltyramine is an alkaloid. N-trans-Sinapoyltyramine can be isolated from Lindera glauca Sieb Zucc .

HY-N7467

Taxuspine X	Others	Others
Taxuspine X is a Diterpenoids product that can be isolated from the stems of the Japanese yew Taxus cuspidata Sieb. et Zucc. .

HY-N16982

Genkwanoid B	Others	Others
Genkwanoid B is a guaiane-type sesquiterpene compound that can be naturally extracted from the dried roots of Daphne genkwa Sieb. et Zucc .

HY-N18210

12-O-Ethyl-1-deacetylnimbolinin B	Others	Others
12-O-Ethyl-1-deacetylnimbolinin B (Compound 1) is a limonoid-type triterpenoid that can be found in the fruit of Melia toosendan Sieb. et Zucc .

HY-N18150

12-O-Methylvolkensin	Others	Cancer
12-O-Methylvolkensin is a limonoid found in the fruits of Melia toosendan Sieb. et Zucc. 12-O-Methylvolkensin shows cytotoxicity against cancer cells. 12-O-Methylvolkensin can be used for the research of cancer, such as human oral epidermoid carcinoma .

HY-N15140

α-Thujaplicin	Drug Isomer Bacterial Fungal Carboxypeptidase	Infection Cancer
α-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC₅₀: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma .

Toosendanin Maximum Cited Publications 6 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Melia toosendan Sieb. et Zucc. Plants Meliaceae Inflammation/Immunology Disease Research Fields Source Classification	Others
Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .

β,β-Dimethylacrylshikonin 1 Publications Verification Isoarnebin I	Quinones Classification of Application Fields Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Boraginaceae Disease Research Fields Source Classification Cancer	HIF/HIF Prolyl-Hydroxylase Apoptosis Notch NO Synthase Bcl-2 Family
β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β,β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β,β-Dimethylacrylshikonin inhibits Notch-1 activation. β,β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth .

Emodin-1-O-β-D-glucopyranoside 1 Publications Verification	Quinones Rheum palmatum L. Classification of Application Fields Anthraquinones Polygonaceae Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Bacterial
Emodin-1-O-β-D-glucopyranoside, isolated from medicinal plant Polygonum cuspidatum Sieb. & Zucc, is a potent and noncompetitive bacterial neuraminidase (BNA) inhibitor with an IC₅₀ of 0.85 μM .

Guaiacin	Zingiber officinale Roscoe Classification of Application Fields Lignans Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Disease Research Fields Source Classification Zingiberaceae	Phosphatase
Guaiacin is a arylnaphthalene type lignin isolated from the barks of Machilus thunbergii SIEB. et ZUCC (Lauraceae). Guaiacin significantly increases alkaline phosphatase activity and osteoblast differentiation .

Chloranthalactone C	Terpenoids Sesquiterpenes Chloranthaceae Plants Chloranthus fortunei (A. Gray) Solms-Laub Source Classification	Parasite
Chloranthalactone C (Compound 43), a lindenane-type sesquiterpenoid, is an antimalarial agent. Chloranthalactone C can be isolated from plant Chloranthus japonicas Sieb. Chloranthalactone C inhibits Chloroquine (HY-17589A)-resistant Plasmodium falciparum strain Dd2 growth. Chloranthalactone C can be used for parasitic infections research .

Shikonofuran A	Natural Products Classification of Application Fields Phenols Polyphenols Metabolic Disease Plants Lithospermum canescens Lehm. Disease Research Fields Boraginaceae Source Classification	Others
Shikonofuran A is a natural product isolated from the root of Lithosperraum erythrorhizon Sieb.

Epifriedelanol acetate	Triterpenes Buxaceae Terpenoids Pachysandra terminalis Siebold & Zucc. Plants Source Classification	Cannabinoid Receptor
Epifriedelanol acetate (Compound Ⅲc) is a nature product. Epifriedelanol acetate can be isolated from Pachysandra terminalis Sieb .

Broussonetine A	Alkaloids Pyrrole Alkaloids Classification of Application Fields Other Diseases Plants Moraceae Broussonetia kazinoki Sieb. et Zucc. Disease Research Fields Source Classification	Others
Broussonetine A is a pyrrolidine alkaloid compound isolated from the branches of Broussonetia kazinoki Sieb .

7-(2'-Deoxyadenosin-N6-yl)aristolactam I	Alkaloids Aristolochia debilis Siebold & Zucc. Other Alkaloids Plants Aristolochiaceae Source Classification	Others
7-(2'-Deoxyadenosin-N6-yl)aristolactam I is a Alkaloids product that can be isolated from the herbs of Aristolochia debilis Sieb. et Zucc .

Shizukanolide F	Chloranthus serratus (Thunb.) Roem. et Schult. Terpenoids Sesquiterpenes Chloranthaceae Plants Source Classification	Fungal
Shizukanolide F is a dimeric sesquiterpene, which is derivated from Chloranthus japonicus Sieb. Shizukanolide F exhibits potent antifungal activities against various plant pathogenic fungi and anti-metastasis breast cancer .

Toosendanin (Standard)	Triterpenes Structural Classification Terpenoids Melia toosendan Sieb. et Zucc. Plants Meliaceae Source Classification	Reference Standards Others
Toosendanin (Standard) is the analytical standard of Toosendanin. This product is intended for research and analytical applications. Toosendanin, a triterpenoid extracted from the bark of fruit of Melia toosendan Sieb. et Zucc., possesses analgesic, insecticidal and anti-inflammatory activities .

Toosendanal	Structural Classification Melia azedarach Linn. Ketones, Aldehydes, Acids Plants Meliaceae Source Classification	Drug Derivative
Toosendanal is a limonoid compound present in the fruits of Melia toosendan Sieb. et al. .

Futoamide	Simple Phenylpropanols Piper kadsura Piperaceae Phenylpropanoids Plants Source Classification	Others
Futoamide is an active compound. Futoamide can be isolated from Piper futokadzura SIEB. et ZUCC .

Taxezopidine L	Taxus cuspidata Siebold & Zucc. Terpenoids Taxaceae Diterpenoids Plants Source Classification	Others
Taxezopidine L is a Diterpenoids product that can be isolated from the seeds of the Japanese yew Taxus cuspidata Sieb. et Zucc. .

N-trans-Sinapoyltyramine	Phenols Polyphenols Plants Lauraceae Lindera glauca (Siebold & Zucc.) Blume Source Classification	Others
N-trans-Sinapoyltyramine is an alkaloid. N-trans-Sinapoyltyramine can be isolated from Lindera glauca Sieb Zucc .

Taxuspine X	Japanese yew Taxus cuspidata Sieb. et Zucc. Terpenoids Taxaceae Diterpenoids Plants Source Classification	Others
Taxuspine X is a Diterpenoids product that can be isolated from the stems of the Japanese yew Taxus cuspidata Sieb. et Zucc. .

Genkwanoid B	Structural Classification Terpenoids Thymelaeaceae Sesquiterpenes Plants Daphne genkwa Sieb. et Zucc. Source Classification	Others
Genkwanoid B is a guaiane-type sesquiterpene compound that can be naturally extracted from the dried roots of Daphne genkwa Sieb. et Zucc .

12-O-Ethyl-1-deacetylnimbolinin B	Structural Classification Natural Products Melia azedarach Linn. Plants Meliaceae Source Classification	Others
12-O-Ethyl-1-deacetylnimbolinin B (Compound 1) is a limonoid-type triterpenoid that can be found in the fruit of Melia toosendan Sieb. et Zucc .

12-O-Methylvolkensin	Structural Classification Natural Products Melia azedarach Linn. Plants Meliaceae Source Classification	Others
12-O-Methylvolkensin is a limonoid found in the fruits of Melia toosendan Sieb. et Zucc. 12-O-Methylvolkensin shows cytotoxicity against cancer cells. 12-O-Methylvolkensin can be used for the research of cancer, such as human oral epidermoid carcinoma .

α-Thujaplicin	Structural Classification Natural Products Cupressaceae Ketones, Aldehydes, Acids Plants Thujopsis dolabrata (Thunberg ex L. f.) Sieb. et Zucc. Source Classification	Drug Isomer Bacterial Fungal Carboxypeptidase
α-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC₅₀: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma .

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