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Results for "

TOP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (2) ADC Antibody (1) ADC Payload (4) Akt (1) AMPK (1) Amyloid-β (1) Antibody-Drug Conjugates (ADCs) (3) Apoptosis (17) ATM/ATR (1) Autophagy (1) Bacterial (3) Bcl-2 Family (2) Biochemical Assay Reagents (2) c-Met/HGFR (1) c-Myc (2) Carbonic Anhydrase (1) Caspase (3) CDK (2) Checkpoint Kinase (Chk) (1) Cholinesterase (ChE) (2) Cyclin G-associated Kinase (GAK) (1) Dengue Virus (1) DNA/RNA Synthesis (10) Drug Isomer (1) Drug Metabolite (1) Drug-Linker Conjugates for ADC (2) Early 2 Factor (E2F) (2) EGFR (2) Environmental Pollutants (1) Estrogen Receptor/ERR (2) Fluorescent Dye (1) Fungal (1) Glycosidase (1) HDAC (4) HIF/HIF Prolyl-Hydroxylase (1) IAP (1) IKZF Family (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Molecular Glues (1) mTOR (2) NF-κB (1) p38 MAPK (3) PARP (2) PI3K (2) PROTACs (1) Reactive Oxygen Species (ROS) (4) Reference Standards (1) Ribosomal S6 Kinase (RSK) (1) Small Interfering RNA (siRNA) (16) Src (3) STING (1) Survivin (1) Syk (2) Topoisomerase (54) β-catenin (1)
By Research Areas:	Cancer (58) Cardiovascular Disease (3) Endocrinology (2) Infection (8) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (3)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (4) Mouse Pre-designed siRNA Sets (4) Human Pre-designed siRNA Sets (8) siRNAs (16)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148819

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT	ADC Payload Topoisomerase	Cancer
NH2-bicyclopentane-7-MAD-MDCPT (Formula I) is a topoisomerase I (TOP1) inhibitor. NH2-bicyclopentane-7-MAD-MDCPT is applicable to the synthesis of the ADC ABBV-969. NH2-bicyclopentane-7-MAD-MDCPT is used in research on lung adenocarcinoma and melanoma .

HY-153278

Q901 CDK7-IN-21	CDK DNA/RNA Synthesis c-Myc Early 2 Factor (E2F) Topoisomerase	Cancer
Q901 (CDK7-IN-21) is a selective and potent CDK7 inhibitor with an IC₅₀ of 10 nM. Q901 disrupts MYC and E2FTOP1-DPCs and sensitizes tumor to TOP1 inhibitors by suppressing RNAPII transition from initiation to elongation. Q901 can inhibit tumor growth and significantly enhances tumor growth inhibition combined with TOP1 inhibitors. Q901 can be used for the research of cancer, such as colon cancer and lung cancer .

HY-164734

Raludotatug Deruxtecan R-DXd; DS-6000	Antibody-Drug Conjugates (ADCs)	Cancer
Raludotatug Deruxtecan is an antibody-drug conjugate targeting CDH6, with an EC₅₀ of 64.7 ng/mL in humans, 70.4 ng/mL in cynomolgus monkeys, and 228 ng/mL in mice. Raludotatug Deruxtecan specifically binds to CDH6 on the surface of cancer cells, triggers lysosomal internalization, and releases the DXd payload that inhibits *TOP1. Raludotatug Deruxtecan induces DNA damage, Chk1* phosphorylation, caspase-3 cleavage, apoptosis, and bystander cell death. Raludotatug Deruxtecan is applicable to research related to serous ovarian cancer and renal cell carcinoma .

HY-171124

Tilatamig samrotecan AZD9592	Antibody-Drug Conjugates (ADCs) EGFR c-Met/HGFR Topoisomerase DNA/RNA Synthesis	Cancer
Tilatamig samrotecan (AZD9592) is an anti-EGFR/c-MET antibody-drug conjugate (ADC). Tilatamig samrotecan consists of an anti-EGFR/c-MET antibody with the drug-linker conjugate being AZ14170133 (HY-145399) (a topoisomerase I (TOP1i) inhibitor payload). Tilatamig samrotecan induces multiple DNA damage response pathway markers (like ATM, ATR, γH2AX). Tilatamig samrotecan selectively binds to EGFR and c-MET, delivering the cytotoxic payload. Tilatamig samrotecan exerts anti-tumor activity in vivo. Tilatamig samrotecan can be used for non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) research .

HY-174374

Topobexin	Topoisomerase	Cardiovascular Disease
Topobexin is a *TOP2B*-selective inhibitor with IC₅₀ values of 0.19 μM and 4.8 μM for TOP2B and TOP2A (DNA decatenation assay). Topobexin binds to non-homologous residues in the obex pocket and targets the ATPase domain of TOP2B. Topobexin prevents anthracycline-induced DNA double-strand break formation, apoptotic signaling mediated by caspase 3/7, 8 and 9, cardiomyocyte morphological changes, mitochondrial depolarization/loss, left ventricular systolic dysfunction, extracellular matrix remodeling, fibrotic alterations, and increases in plasma cardiac troponin T and BNP. Topobexin does not impair the antiproliferative effects of anthracyclines in cancer cells, exhibits no intrinsic cytotoxicity in cardiomyocytes, and is well tolerated in rabbits. Topobexin can be used in studies related to anthracycline-induced cardiotoxicity .

HY-171689

Puxitatug samrotecan AZD 8205; P-Sam	Antibody-Drug Conjugates (ADCs) Topoisomerase	Cancer
Puxitatug samrotecan (AZD 8205) is a B7-H4-directed antibody-drug conjugate (ADC) bearing a Topoisomerase I inhibitor (TOP1i) payload. Puxitatug samrotecan improves HR ⁺/HER2 ^- breast cancer .

HY-U00248A

LMP744 hydrochloride MJ-III65 hydrochloride; NSC706744 hydrochloride	Topoisomerase	Cancer
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity .

HY-175203

Topi MF-6	Topoisomerase ADC Payload	Cancer
Topi MF-6 is a DNA topoisomerase I (Top1) inhibitor. Topi MF-6 can be used as an ADC payload .

HY-148819A

NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride	ADC Payload Topoisomerase	Cancer
NH2-bicyclopentane-7-MAD-MDCPT hydrochloride (Formula I) is a topoisomerase I (TOP1) inhibitor. NH2-bicyclopentane-7-MAD-MDCPT hydrochloride is applicable to the synthesis of the ADC ABBV-969. NH2-bicyclopentane-7-MAD-MDCPT hydrochloride is used in research on lung adenocarcinoma and melanoma .

HY-163099

P5(PEG24)-VC-PAB-Exatecan	Drug-Linker Conjugates for ADC Topoisomerase Apoptosis	Cancer
P5 (PEG24)-VC-PAB-Exatecan is a *TOP1* inhibitor payload with antibody-conjugation-dependent activity. Conjugation of P5 (PEG24)-VC-PAB-Exatecan with Trastuzumab (HY-P9907) generates a DAR8 antibody-drug conjugate (ADCs) with antibody-like pharmacokinetic properties. P5 (PEG24)-VC-PAB-Exatecan induces S-phase and G2-M-phase cell cycle arrest, DNA damage and apoptosis in target-positive tumor cells, and releases damage-associated molecular patterns (DAMP) related to immunogenic cell death (ICD). The ADCs prepared from it exert bystander killing effects on non-target tumor cells. ADCs based on P5 (PEG24)-VC-PAB-Exatecan exhibit linker stability in vitro and in vivo, show in vivo efficacy, and can be used in research related to HER2-positive cancers .

HY-122594

BNS-22	Topoisomerase	Cancer
BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC₅₀ values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity .

HY-U00248

LMP744 MJ-III65; NSC706744	Topoisomerase	Cancer
LMP744 (MJ-III65) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity .

HY-111630

PluriSIn #2 3 Publications Verification	Topoisomerase	Cancer
PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs) .

HY-N0114A

(±)-Evodiamine 1 Publications Verification	Topoisomerase Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
(±)-Evodiamine, a quinazolinocarboline alkaloid, is a *Top1* inhibitor. Evodiamine exhibits anti-inflammatory, antiobesity, and antitumor effects. (±)-Evodiamine inhibits the proliferation of a wide variety of tumor cells by inducing their apoptosis .

HY-168489

OBI-992 drug-linker	Drug-Linker Conjugates for ADC	Cancer
OBI-992 drug-linker is a drug-linker conjugate composed of a TOP I inhibitor Exatecan (HY-13631) and a linker. OBI-992 drug-linker exhibits antitumor property in mouse models and can be used for synthesis of ADC OBI-992 .

HY-116785

BRD32048	DNA/RNA Synthesis	Cancer
BRD32048 is a direct binder of ETV1 with a K_D of 17.1 μM. BRD32048 modulates both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 inhibits ETV1 acetylation and promotes its degradation. BRD32048 acts as a top candidate ETV1 perturbagen .

HY-160857

TOP5668	Estrogen Receptor/ERR	Endocrinology
TOP5668 is an orally active follicle-stimulating hormone receptor allosteric agonist. TOP5668 can induce the production of testosterone in stromal cells and promote follicular genesis and superovulation in rats .

HY-160005

LMP517 NSC 781517	Topoisomerase DNA/RNA Synthesis	Cancer
LMP517 (NSC 781517) is a potent and non-camptothecin Topoisomerase I and II (TOP1 and *TOP2) dual inhibitor. LMP517 can induce TOP1 and TOP2 cleavage complexes (TOP1ccs and TOP2ccs). LMP517 can induce cancer cells DNA* damage and γH2AX production. LMP517 can be used for the research of cancer, such as small cell lung cancer .

HY-18350

Indimitecan LMP776	Topoisomerase	Cancer
Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities .

HY-118581

Coralyne chloride 1 Publications Verification	Topoisomerase	Cancer
Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage . Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes .

HY-13550

Ametantrone NSC 196473; NSC 290813	DNA/RNA Synthesis	Cancer
Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break .

HY-164143

T638	Topoisomerase	Cancer
T638 is a topoisomerase II (TOP2) inhibitor. T638 inhibits *TOP2A* activity with a IC₅₀ of 0.7 uM. T638 strongly inhibits cancer cell growth .

HY-118911

ATM Inhibitor-10	ATM/ATR	Cancer
ATM Inhibitor-10 (compound 74), a 3-quinoline carboxamide, is a highly selective and orally active ATM inhibitor (IC₅₀: 0.6 nM). ATM Inhibitor-10 has anti-tumor activity in SW620 xenograft models. ATM Inhibitor-10 is synergistic with Top I inhibitors .

HY-P990947

Tilatamig AZD9592 Antibody	ADC Antibody EGFR	Cancer
Tilatamig (AZD9592 Antibody) is a human antibody of the Ig (G1-κ_G1-λ2) subtype that targets EGFR/MET. Tilatamig conjugates with the *Top1* inhibitor AZ14170133 (HY-145399) to form the antibody-drug conjugate (ADC) Tilatamig samrotecan (HY-171124) (AZD9592). Tilatamig accurately targets NSCLC models including EGFR-mutant, EGFR-wildtype, and EGFR tyrosine kinase inhibitor-treated ones, and its activity correlates with high expression of EGFR, c-MET and SLFN11. Tilatamig is available for in vivo anti-tumor studies in patient-derived xenograft models of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) .

HY-126142

Top1 inhibitor 1	Topoisomerase ADC Payload	Cancer
Top1 inhibitor 1 (compound 28) is a potent human topoisomerase I (Top1) inhibitor with an IC₅₀ value of 29 nM .

HY-RS14897

TOP2B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TOP2B Human Pre-designed siRNA Set A contains three designed siRNAs for TOP2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TOP2B Human Pre-designed siRNA Set A TOP2B Human Pre-designed siRNA Set A

HY-RS14893

TOP1MT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TOP1MT Human Pre-designed siRNA Set A contains three designed siRNAs for TOP1MT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TOP1MT Human Pre-designed siRNA Set A TOP1MT Human Pre-designed siRNA Set A

HY-RS14899

TOP3B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TOP3B Human Pre-designed siRNA Set A contains three designed siRNAs for TOP3B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TOP3B Human Pre-designed siRNA Set A TOP3B Human Pre-designed siRNA Set A

HY-175700

YCJ-02	Topoisomerase Apoptosis	Cancer
YCJ-02 is a selective Topoisomerase I (Top I) inhibitor. YCJ-02 can inhibit cell proliferation and induce apoptosis and G2/M phase arrest. YCJ-02 can induce DNA damage and increaseγ-H2AX levels. YCJ-02 can promote Top I deqradation via a ubiquitin/26S proteasome pathway. YCJ-02 increases the expressions of pro-apoptotic proteins Bad, Bax, and cleaved caspase-3. YCJ-02 shows broad-spectrum antitumor activity. YCJ-02 can be used for the research of cancer, such as intrahepatic cholangiocarcinoma (ICC) .

HY-RS14902

TOPORS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TOPORS Human Pre-designed siRNA Set A contains three designed siRNAs for TOPORS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TOPORS Human Pre-designed siRNA Set A TOPORS Human Pre-designed siRNA Set A

HY-153278A

Q901 TFA CDK7-IN-21 TFA	CDK DNA/RNA Synthesis c-Myc Early 2 Factor (E2F) Topoisomerase	Cancer
Q901 (CDK7-IN-21) TFA is a selective and potent CDK7 inhibitor with an IC₅₀ of 10 nM. Q901 TFA disrupts MYC and E2FTOP1-DPCs and sensitizes tumor to TOP1 inhibitors by suppressing RNAPII transition from initiation to elongation. Q901 TFA can inhibit tumor growth and significantly enhances tumor growth inhibition combined with TOP1 inhibitors. Q901 TFA can be used for the research of cancer, such as colon cancer and lung cancer .

HY-149348

DiPT-4	Topoisomerase PARP Apoptosis	Cancer
DiPT-4 is a dual *TOP1/PARP1* inhibitor that induces massive DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells. DiPT-4 has the potential to overcome cancer drug resistance .

HY-123393

PNU-142586	Topoisomerase	Others
PNU-142586 is the major metabolite of Linezolid (HY-10394). PNU-142586 can inhibit the activity of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B). PNU-142586 interferes with DNA replication and transcription by blocking the binding of DNA to TOP2 and inhibiting ATP hydrolysis, ultimately leading to antiproliferative and cytotoxic effects, including mitochondrial dysfunction. PNU-142586 can be used to study Linezolid-induced hematotoxicity and its molecular mechanism .

HY-118942

Topovale ARC 111	Topoisomerase	Cancer
Topovale (ARC 111) is a topoisomerase I inhbitor. Topovale is an antitumor agent, and shows low nM cytotoxicity against a panel of cancer cells. Topovale induces reversible topoisomerase I (TOP1) cleavage complexes in tumor cells .

HY-W008874

meso-Tetra(4-pyridyl)porphine	Topoisomerase	Cancer
meso-Tetra(4-pyridyl)porphine (Compound 10) is a porphyrin derivative. meso-Tetra(4-pyridyl)porphine is a weak inhibitor of human topoisomerase I (Top1) with an EC₅₀ value greater than 50 µM. meso-Tetra(4-pyridyl)porphine can be used in tumor research .

HY-160856

TOP5300 TOP05300	Estrogen Receptor/ERR	Endocrinology
TOP5300 is an orally active follicle-stimulating hormone receptor allosteric agonist. TOP5300 can induce the production of testosterone in stromal cells and promote follicular genesis and superovulation in rats .

HY-175834

*DNA/TOP2A-IN-1*	Topoisomerase Reactive Oxygen Species (ROS) Apoptosis Microtubule/Tubulin	Cancer
DNA/TOP2A-IN-1 is an inhibitor of DNA and *TOP2A. DNA/TOP2A-IN-1 selectively binds to TOP2A, not TOP2B, and interacts with DNA and TOP2A to form a stable DM1-TOP2A-DNA* ternary complex. DNA/TOP2A-IN-1 induces DNA damage, increases reactive oxygen species (ROS) and triggers apoptosis in triple-negative breast cancer (TNBC) cells. DNA/TOP2A-IN-1 disrupts microtubule distribution and induces cell cycle arrest. DNA/TOP2A-IN-1 shows strong antiproliferative activity and inhibits cell migration. DNA/TOP2A-IN-1 inhibits tumor growth and can be used for TNBC research .

HY-145852

Top/HDAC-IN-2	HDAC Topoisomerase Apoptosis	Cancer
Top/HDAC-IN-2 (45b), a Top and HDAC dual inhibitor, exhibits potent antitumor activities and induces apoptosis .

HY-160930

TOP1288	p38 MAPK Src Syk	Inflammation/Immunology
TOP1288 is a narrow spectrum kinase inhibitor for P38α, Src and Syk kinase, with IC₅₀ of 116nM, 24nM and 659nM, respectively. TOP1288 inhibits inflammatory cytokine release from inflamed biopsies and myofibroblasts .

HY-143265

Topoisomerase I inhibitor 2	Topoisomerase Apoptosis Caspase	Cancer
Topoisomerase I inhibitor 2 (ZML-8) is a highly selective inhibitor of DNA topoisomerase I (Top1). Topoisomerase I inhibitor 2 inhibits *Top1* activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis, exhibits anti-tumor effect .

HY-178036

ZM484	MDM-2/p53 Topoisomerase Bcl-2 Family Caspase Cyclin G-associated Kinase (GAK)	Cancer
ZM484 is a potent dual *p53-MDM2/TOP1* inhibitor that exhibits antiproliferative and antitumor activity both in vitro and in vivo. ZM484 effectively upregulates p53 and MDM2 proteins and maintains TOP1 inhibitory activity by the release of camptothecin (CPT) and a potent p53-MDM2 inhibitor. ZM484 induces cell cycle arrest and apoptosis by regulating the expression of key apoptosis- and cycle-related proteins, including caspase-3, Bcl-2, and Cyclin B1. ZM484 can be used for colorectal cancer research .

HY-P4926

Mca-SEVKMDAEFRK(Dnp)RR-NH2	Amyloid-β	Neurological Disease
Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research .

HY-B2143

Montmorillonite	Environmental Pollutants Biochemical Assay Reagents Bacterial	Infection
Montmorillonite is composed of two layers of co-top connected silicon oxygen tetrahedral sheet and one layer of co-edge connected aluminum (magnesium) oxygen (hydroxide) octahedral sheet, which consists of a 2:1 structure containing water of crystal. Montmorillonite can be used for large-scale industrial decontamination and can effectively remove harmful ions in sewage. Montmorillonite can also be used as a carrier of ionic antibacterial agents because of its exchangeable hydrated cations, which can adsorb bacteria .

HY-176762

TOP3B-IN-1	Topoisomerase	Infection Cancer
TOP3B-IN-1 (NSC-260610) is a Topoisomerase IIIβ (TOP3B) inhibitor. TOP3B-IN-1 fails to induce the formation of TOP3B cleavage complexes (TOP3Bccs) with both DNA and RNA, and destabilizes TOP3Bccs. TOP3B-IN-1 can be used as a control compound for the development of inhibitors targeting TOP3B .

HY-159935

Top1-IN-2	Topoisomerase Apoptosis	Cancer
Top1-IN-2 (Compound 1a) is a topoisomerase 1 (Top1) inhibitor. Top1-IN-2 inhibits P-gp resistant tumor cells growth and induces cell apoptosis .

HY-161957

Top1/2-IN-1	Topoisomerase	Cancer
Top1/2-IN-1 (compound 23) is an orally available dual inhibitor of *Top1/2* with antiproliferative activity. Top1/2-IN-1 damages DNA with increased levels of reactive oxygen species, inducing apoptosis and cell cycle arrest in cancer cells. Top1/2-IN-1 exhibits in vivo antitumor activity in xenograft models .

HY-178029

*RSK2/TOP2-IN-1*	Ribosomal S6 Kinase (RSK) Topoisomerase Apoptosis Autophagy Reactive Oxygen Species (ROS)	Cancer
RSK2/TOP2-IN-1 is a *RSK2/TOP2* dual inhibitor. RSK2/TOP2-IN-1 targets key tumor progression enzymes including ribosomal S6 kinase 2 and topoisomerases IIα/IIβ. RSK2/TOP2-IN-1 shows selectivity index > 2 against all squamous cell carcinoma (SCC) cell lines. RSK2/TOP2-IN-1 can induce cell apoptosis, autophagy and ROS production. RSK2/TOP2-IN-1 can be used for the research of cancer, such as squamous cell carcinoma .

HY-125387

TOP1210	Src	Inflammation/Immunology
TOP1210 is a narrow-spectrum tyrosine kinase inhibitor with potent inhibitory activity against P38α, Src, and Syk kinases. TOP1210 effectively reduced proinflammatory cytokines released by peripheral blood monocytes, primary macrophages, HT29 cells, inflammatory cells in ulcerative colitis (UC) biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. TOP1210 showed significant anti-inflammatory effects in cell experiments and UC biopsies, superior to some selective kinase inhibitors. The multi-kinase inhibition of TOP1210 provides the possibility of obtaining a wider range of therapeutic effects, especially in the regulation of autoimmune responses .

HY-144654

*HDAC/Top-IN-1*	HDAC Topoisomerase	Cancer
HDAC/Top-IN-1 is an orally active and pan *HDAC/Top* dual inhibitor with IC₅₀s of 0.036 μM, 0.14 μM, 0.059 μM, 0.089 μM and 9.8 μM for HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8. HDAC/Top-IN-1 efficiently induces apoptosis with S cell-cycle arrest in HEL cells. HDAC/Top-IN-1 has exhibits excellent in vivo antitumor efficacy .

HY-145851

Top/HDAC-IN-1	HDAC Topoisomerase Apoptosis	Cancer
Top/HDAC-IN-1 (Compound 29b) is a topoisomerase/HDAC dual inhibitor with IC₅₀s of 18, 230, 790, 87, and 5250 nM for HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, respectively. Top/HDAC-IN-1 exhibits potent antitumor activities against the HCT116 cell line with the IC₅₀ of 180 nM. Top/HDAC-IN-1 efficiently induces apoptosis with G2 cell cycle arrest in HCT116 cells .

Cat. No.	Product Name

HY-L943

MCE‑18 Novelty drug‑like Library

37030 compounds

MCE-18 stands for Medicinal Chemistry Evolution 2018, which was first published in Journal of Medicinal Chemistry in 2019 for assessing molecular novelty and three-dimensional complexity. Developed based on Clarivate global pharmaceutical patent database, this descriptor was constructed via big-data analysis covering 28,161 patented lead compounds, 1,370 approved drugs and nearly 30,000 preclinical-to-phase III drug candidates from 23 top pharmaceutical companies worldwide between 1950 and 2018, followed by structural clustering and removal of redundant outdated scaffolds for data denoising. Its scoring system integrates five core structural features including aromatic ring (AR), aliphatic heterocycle (NAR), chiral center (CHIRAL), spiro atom (SPIRO), cyclic and acyclic sp³ carbon ratio together with a quadratic topological correction factor. Breaking the limitations of the single Fsp³ parameter, MCE-18 effectively distinguishes conventional flat aromatic scaffolds from modern 3D-enriched novel chemotypes, overcoming typical drawbacks of traditional compound libraries such as scaffold redundancy, low screening hit rates and poor compatibility with allosteric and PPI-related difficult targets.

This library contains over 37,000 structurally diverse compounds with favorable overall drug-likeness, suitable for high-throughput screening against canonical targets including kinases, GPCRs and proteases as well as challenging allosteric and PPI targets. Compounds comply with the developmental trend of modern novel drug discovery, supporting routine primary screening as well as early hit identification of allosteric modulators and PPI inhibitors, serving as an efficient screening resource for early-stage innovative drug discovery.

Cat. No.	Product Name	Target	Research Area

HY-P4926

Mca-SEVKMDAEFRK(Dnp)RR-NH2	Amyloid-β	Neurological Disease
Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research .

HY-P11715

Abz-GFDPFRQ-EDDnp	Fluorescent Dye	Neurological Disease
Abz-GFDPFRQ-EDDnp is a fluorogenic substrate for metallothionein oligopeptidase (λ_ex=320 nm, λ_em=420 nm). Abz-GFDPFRQ-EDDnp is used to determine the enzymatic activity of metallothionein oligopeptidase in tissue extracts and for research on temporal lobe epilepsy .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990947

Tilatamig AZD9592 Antibody	ADC Antibody EGFR	Cancer
Tilatamig (AZD9592 Antibody) is a human antibody of the Ig (G1-κ_G1-λ2) subtype that targets EGFR/MET. Tilatamig conjugates with the *Top1* inhibitor AZ14170133 (HY-145399) to form the antibody-drug conjugate (ADC) Tilatamig samrotecan (HY-171124) (AZD9592). Tilatamig accurately targets NSCLC models including EGFR-mutant, EGFR-wildtype, and EGFR tyrosine kinase inhibitor-treated ones, and its activity correlates with high expression of EGFR, c-MET and SLFN11. Tilatamig is available for in vivo anti-tumor studies in patient-derived xenograft models of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) .

Species:	Virus (1) Human (3)
Tag:	His (2) Tag Free (1)
Source:	Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704742

	TOP2A Protein, Human TOP2A; DNA TOPoisomerase 2-alpha; TOP2; DNA TOPoisomerase II; alpha isozyme	Human	E. coli
	TOP2A Protein, Human is the recombinant human-derived TOP2A protein, expressed by E. coli, with tag free tag.

HY-P73584

	TOP1 Protein, Human (765a.a, sf9, His) DNA TOPoisomerase 1; TOP1	Human	Sf9 insect cells
	The TOP1 protein is critical in cellular processes, mitigating DNA supercoiling and torsional tension during replication and transcription. It does this by transiently cutting and rejoining a DNA strand, introducing breaks through transesterification. TOP1 Protein, Human (765a.a, sf9, His) is the recombinant human-derived TOP1 protein, expressed by Sf9 insect cells , with N-His labeled tag.

HY-P73585

	TOP1 Protein, Human (575a.a, sf9, His) DNA TOPoisomerase 1; TOP1	Human	Sf9 insect cells
	The TOP1 protein is critical in cellular processes, mitigating DNA supercoiling and torsional tension during replication and transcription. It does this by transiently cutting and rejoining a DNA strand, introducing breaks through transesterification. TOP1 Protein, Human (575a.a, sf9, His) is the recombinant human-derived TOP1 protein, expressed by Sf9 insect cells , with N-His labeled tag.

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Host:	Mouse (5) Rabbit (5)
Reactivity:	Human (10) Mouse (7) Rat (9)
Application:	IHC-P (8) ICC/IF (5) IP (2) IHC-F (2) WB (10) FC (2) ELISA (3)
Isotype:	IgG (5) IgG1 (1) IgG2b (4)
Conjugation:	Non-conjugated (10)
Clonality:	Monoclonal (5) Monoclonal Antibody (1) Recombinant (3)
Modification:	Unmodified (6)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84062

	Topoisomerase II alpha Antibody (YA3759) TOP2; TP2A	WB, ICC/IF, FC, ELISA	Human, Rat
	Topoisomerase II alpha Antibody (YA3759) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P84062A

	Topoisomerase II alpha Antibody (YA3759)(PBS only) TOP2; TP2A	WB, ICC/IF, FC, ELISA	Human, Rat
	Topoisomerase II alpha Antibody (YA3759) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P85929

	Topoisomerase II alpha Antibody (YA5621) alpha isozyme; ATP hydrolyzing DNA TOPoisomerase II alfa; DNA gyrase; DNA TOPoisomerase; ATP hydrolyzing; DNA TOPoisomerase 2 alpha; DNA TOPoisomerase 2-alpha; DNA TOPoisomerase II 170 kD; DNA TOPoisomerase II alpha isozyme; DNA TOPoisomerase II; DNA TOPoisomerase2; TOP 2A; TOP2; TOP2A; TOP2A_HUMAN; TOPoisomerase DNA II alpha 170 kDa; TP2A	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
	Topoisomerase II alpha Antibody (YA5621) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P82492

	Topoisomerase I Antibody (YA2237) TOP1; DNA TOPoisomerase 1; DNA TOPoisomerase I	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Topoisomerase I Antibody (YA2237) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Topoisomerase I.

HY-P88448

	THOP1 (Thimet Oligopeptidase) Antibody (YA8132) EP24.15; MEPD_HUMAN; MP78; TOP	WB, IHC-P	Human, Mouse, Rat
	THOP1 (Thimet Oligopeptidase) Antibody (YA8132) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to THOP1 (Thimet Oligopeptidase).

HY-P82492A

	Topoisomerase I Antibody (YA2237)(PBS only) TOP1; DNA TOPoisomerase 1; DNA TOPoisomerase I	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Topoisomerase I Antibody (YA2237) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Topoisomerase I.

HY-P88448A

	THOP1 (Thimet Oligopeptidase) Antibody (YA8132)(PBS only) EP24.15; MEPD_HUMAN; MP78; TOP	WB, IHC-P	Human, Mouse, Rat
	THOP1 (Thimet Oligopeptidase) Antibody (YA8132) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to THOP1 (Thimet Oligopeptidase).

HY-P80980

	Topoisomerase II alpha Antibody (YA3544) DNA TOPoisomerase II; DNA TOPoisomerase II-alpha; TOP2; TP2A; alpha isozyme, TOPoisomerase II alpha	WB, IHC-P, IP	Human, Mouse, Rat
	Topoisomerase II alpha Antibody (YA3544) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P80980A

	Topoisomerase II alpha Antibody (YA3544)(PBS only) DNA TOPoisomerase II; DNA TOPoisomerase II-alpha; TOP2; TP2A; alpha isozyme, TOPoisomerase II alpha	WB, IHC-P, IP	Human, Mouse, Rat
	Topoisomerase II alpha Antibody (YA3544) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Topoisomerase II alpha.

HY-P87126

	TopBP1 Antibody (YA6819) DNA TOPoisomerase 2 binding protein 1 antibody; DNA TOPoisomerase 2-binding protein 1 antibody; DNA TOPoisomerase II binding protein 1 antibody; DNA TOPoisomerase II binding protein antibody; DNA TOPoisomerase II-beta-binding protein 1 antibody; DNA TOPoisomerase II-binding protein 1 antibody; DNA TOPoisomerase IIbeta binding protein 1 antibody; Hypothetical protein KIAA0259 [Fragment] antibody; KIAA0259 antibody; TOP2BP1 antibody; DNA TOPoisomerase 2 binding protein 1 antibody; DNA TOPoisomerase 2-binding protein 1 antibody; DNA TOPoisomerase II binding protein 1 antibody; DNA TOPoisomerase II binding protein antibody; DNA TOPoisomerase II-beta-binding protein 1 antibody; DNA TOPoisomerase II-binding protein 1 antibody; DNA TOPoisomerase IIbeta binding protein 1 antibody; Hypothetical protein KIAA0259 [Fragment] antibody; KIAA0259 antibody; TOP2BP1 antibody; TOPB1_HUMAN antibody; TOPBP 1 antibody; TOPBP1 antibody; TOPoisomerase (DNA) II binding protein 1 antibody; TOPoisomerase II binding protein 1 antibody;	WB, IHC-P	Human
	TopBP1 Antibody (YA6819) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TopBP1.