1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. PluriSIn #2

PluriSIn #2 

Cat. No.: HY-111630
Handling Instructions

PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs).

For research use only. We do not sell to patients.

PluriSIn #2 Chemical Structure

PluriSIn #2 Chemical Structure

CAS No. : 56563-17-8

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Description

PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1].

IC50 & Target[1]

topoisomerase II alpha

 

In Vitro

PluriSIn #2 (20 µM; 12 hours) treatment reduces TOP2A expression at the protein level[1].
A 24h exposure of PluriSIn #2 (20 µM) is sufficient to induce massive cell death in hPSCs, but doesn’t affect the viability of various other cell types derived from them[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: B153 and HUES9 human pluripotent stem cells (hPSCs)
Concentration: 20 µM
Incubation Time: 12 hours
Result: Reduced TOP2A expression at the protein level.
Molecular Weight

249.20

Formula

C₁₁H₈FN₃O₃

CAS No.

56563-17-8

SMILES

O=C(N(C(N1)=O)C=C(F)C1=O)NC2=CC=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

PluriSIn #2TopoisomeraseTOP2AhPSCstranscriptionalInhibitorinhibitorinhibit

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PluriSIn #2
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