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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
TRX1
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "TRX1" in MCE Product Catalog:
13
PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1); inhibits the growth of MCF-7 and HT-29 cells with IC50 values of 1.9 and 2.9 μM, respectively.
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Target:
Domaines de recherche:
ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity [1] .
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Cat. No.: HY-P73431A
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Thioredoxin; TXN; TRX; ADF; TRX1; SASP
Cat. No.: HY-P990353
Synonyms: TRX1
Target:
Domaines de recherche:
Cat. No.: HY-108534
CAS No.: 485842-97-5
Synonyms: AW 464
Domaines de recherche:
PMX464 (AW 464) is a thiol-reactive quinol compound and an inhibitor of the thioredoxin-thioredoxin reductase (Trx/TrxR) system, with an IC50 value of 6.5 μM against TrxR. PMX464 acts by irreversibly inhibiting the thioredoxin (Trx-1) system, blocking HIF-1α transcriptional activation and the NF-κB inflammatory pathway, inducing apoptosis, attenuating platelet function and inhibiting thrombosis, and specifically disrupting the trypanothione antioxidant metabolic network in parasites. PMX464 is used in research concerning malignant tumors (colorectal cancer, breast cancer, renal cancer, and leukemia), pulmonary inflammation, African sleeping sickness, and antithrombotic applications [1] .
Cat. No.: HY-D1260
Synonyms: PSH-red
Cat. No.: HY-RS15287
Target:
Domaines de recherche:
TXN Human Pre-designed siRNA Set A contains three designed siRNAs for TXN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Synonyms: (R,S,R)-LH601A
Target:
Domaines de recherche:
(R,S,R)-ML334 is the isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity [1] .
Cat. No.: HY-164259
CAS No.: 840474-95-5
Target:
Domaines de recherche:
AJM 290 is a Trx-1 inhibitor. AJM 290 is an inhibitor of the HIF-1α COOH-terminal transactivation domain, and blocks HIF-1 binding to DNA [1].
Cat. No.: HY-13734R
CAS No.: 141400-58-0
Synonyms: IV-2 (Standard)
Target:
Domaines de recherche:
PX-12 (Standard) is the analytical standard of PX-12. This product is intended for research and analytical applications. PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1); inhibits the growth of MCF-7 and HT-29 cells with IC50 values of 1.9 and 2.9 μM, respectively.
Cat. No.: HY-P73432A
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Thioredoxin; TXN; TRX; ADF; TRX1; SASP
Cat. No.: HY-N0353R
CAS No.: 13657-68-6
Synonyms: (+)-Curdione (Standard)
Cat. No.: HY-P85388
Synonyms: TXN; TRDX; TRX; TRX1; Thioredoxin; TRX; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP
Cat. No.: HY-P85388A
Synonyms: TXN; TRDX; TRX; TRX1; Thioredoxin; TRX; ATL-derived factor; ADF; Surface-associated sulphydryl protein; SASP
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
