2 Results for "

Xestospongin C

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Xestospongin C" in MCE Product Catalog:

11
11 Cited Publications
Cat. No.: HY-103312
CAS No.: 88903-69-9
Purity:  ≥99.0%
Synonyms: (-)-Xestospongin C
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca 2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca 2+ signaling in neuronal and nonneuronal cells .
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Cat. No.: HY-120985
CAS No.: 123000-02-2
Target:  

Calcium Channel

Research Areas:  

Neurological Disease

Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.
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