Zn ion

Pathways Recommended:	Membrane Transporter/Ion Channel

By Targets:	Amino Acid Derivatives (1) Amyloid-β (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Autophagy (1) Bacterial (3) Biochemical Assay Reagents (8) Carbonic Anhydrase (2) Carboxypeptidase (1) Cholinesterase (ChE) (2) Endogenous Metabolite (3) ERK (1) Fluorescent Dye (4) Fungal (1) Interleukin Related (1) MDM-2/p53 (1) Monoamine Oxidase (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Tau Protein (1) TNF Receptor (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (5) Metabolic Disease (2) Neurological Disease (4)
Click Chemistry:	Alkynes (1)

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-119287

TSQ 5 Publications Verification	Fluorescent Dye	Others
TSQ is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence (Ex/Em = 334/495 nm) .

HY-W127776

Zn(Ⅱ)-EDTA disodium tetrahydrate Ethylenediaminetetraacetic acid zinc disodium tetrahydrate	Biochemical Assay Reagents	Others
Zn(II)-EDTA (Ethylenediaminetetraacetic acid zinc) disodium tetrahydrate is a coordinating agent. Zn(II)-EDTA disodium tetrahydrate coordinates with Zn ²⁺ to modify its solvated structure, provides pre-synthesized EDTA-Zn complexes that release Zn ²⁺ to repair zinc anode defects under interfacial electric field, adsorbs onto zinc anode surface to block oxygen and water molecules, inhibits corrosion and hydrogen evolution reactions, promotes uniform Zn ²⁺ deposition, suppresses zinc dendrite formation, and modulates the hydrogen bonding network within the electrolyte. Zn(II)-EDTA disodium tetrahydrate acts as an electrolyte additive to enhance reversibility and stability of zinc anodes in aqueous zinc-ion batteries .

HY-NP009

α-Lactalbumin	Bacterial	Infection Neurological Disease
α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca ²⁺, Mg ²⁺, Mn ²⁺, Na ⁺, K ⁺ and Zn ²⁺ ions; among these, Ca ²⁺ binding enhances protein stability, while Zn ²⁺ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions .

HY-126823

Phen Green SK diacetate (5/6-mixture) PGSK diacetate (5/6-mixture)	Fluorescent Dye	Others
Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture)) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe ²⁺, Cd ²⁺, Co ²⁺, Ni ²⁺, Zn ²⁺, etc. Phen green SK (PGSK) diacetate chelates Fe ²⁺, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively .

HY-W011060

Cryptand 2.2.2 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane	Biochemical Assay Reagents	Others
Cryptand 2.2.2 (4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane) is a metal ion chelator. Cryptand 2.2.2 forms stable mononuclear, protonated and dinuclear complexes with copper (II) ions; forms protonated complexes with hydrogen ions; and also forms stable complexes with Zn ²⁺, Co ²⁺, Ni ²⁺, Cd ²⁺, Hg ²⁺ and Pb ²⁺ ions. Cryptand 2.2.2 can be used for the preparation of nanoparticles, transition metal compounds, etc.

HY-D0179

Cyclam	Biochemical Assay Reagents	Infection Cardiovascular Disease
Cyclam is a metal chelator that forms metal complexes with a variety of metal ions. Cyclam metal complexes exhibits anti-HIV (such as AMD3100), nitric oxide (NO) releasing and scavenging (such as Zn(II)-Cyclam and Ru(II)-Cyclam), and SOD mimetic (such as Mn(III)-Cyclam and Zn(II)-Cyclam) activities .

HY-158779

Sulfane sulfur probe 4 SSP4	Fluorescent Dye	Others
Sulfane sulfur probe 4 (SSP4) is a fluorescent probe used to detect sulfane sulfur species (E_x/E_m=494/515 nm). Sulfane sulfur probe 4 exhibits high sensitivity in detecting sulfane sulfur, even in the presence of other substances such as homocysteine, methionine, cysteine, glutathione, N-acetyl-L-cysteine, glycine, tyrosine, tryptophan, arginine, and metal ions (Fe ²⁺, Fe ³⁺, Mg ²⁺, Ca ²⁺, and Zn ²⁺) .

HY-Y0850U5

PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) Polyvinyl alcohol (Mw 27000, 98-99% hydrolyzed, ~600 polymerization); Poly(Ethenol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)	Biochemical Assay Reagents Fungal	Infection
PVA (Polyvinyl alcohol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) is a nonionic ethanol homopolymer with hydrophilicity, water solubility and biodegradability. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) exhibits biocompatibility, non-toxicity and non-carcinogenicity, as well as antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can serve as a solubilizer, stabilizer, mucoadhesive agent and sustained-release agent, and has a synergistic solubilizing effect on voriconazole/sulfobutyl ether β-cyclodextrin complexes. By stabilizing such complexes, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) forms freeze-thaw hydrogels with high mucoadhesion, sustained drug release and ex vivo corneal permeability. When compounded with hyaluronic acid hydrogels, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) supports chondrocyte growth in vitro, and also forms complexes with Cu ²⁺, Co ²⁺, Ni ²⁺ and Zn ²⁺ ions. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can be used in studies related to fungal keratitis, bacterial infections and fungal infections .

HY-109560

Pentetate zinc trisodium Zn-DTPA trisodium	Biochemical Assay Reagents	Others
Pentetate zinc trisodium (Zn-DTPA trisodium) forms stable chelates with metal ions by exchanging zinc for a metal of greater binding capacity .

HY-DY1055

TSQ (solution)	Fluorescent Dye	Others
TSQ (solution) is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence (Ex/Em = 334/495 nm) . Solvent and concentration: DMSO: 10 mM

HY-P2516

Tau Peptide (275-305) (Repeat 2 domain)	Tau Protein	Neurological Disease
Tau Peptide (275-305) (Repeat 2 domain) is the Alzheimer's Tau fragment R2, corresponding to the second repeat unit of the microtubule-binding domain, which is believed to be pivotal to the biochemical properties of full tau protein. Tau Peptide (275-305) specifically coordinates with group IIB metal ions (Zn²⁺, Cd²⁺, Hg²⁺), which can induce their conformational changes and significantly promote their pathological accumulation. Tau Peptide (275-305) can be used to study the role of heavy metals in neurodegenerative diseases .

HY-W1113135

Carboxymethyl-β-cyclodextrin sodium salt	Biochemical Assay Reagents	Others
Carboxymethyl-β-cyclodextrin sodium salt is a negatively charged β-cyclodextrin derivative, as well as a metal ion chelator and solubilizing reagent. Carboxymethyl-β-cyclodextrin sodium salt forms stable aqueous complexes with Ba ²⁺, Ca ²⁺, Cd ²⁺, Ni ²⁺, Pb ²⁺, Sr ²⁺, and Zn ²⁺ ions. Carboxymethyl-β-cyclodextrin sodium salt derived hydrogel carriers support oral insulin delivery via paracellular permeation across Caco-2 monolayers and produce sustained hypoglycemic effects in diabetic mice. Carboxymethyl-β-cyclodextrin sodium salt can be conjugated onto folate-modified BSA nanoparticles to boost folate receptor-mediated endocytosis, elevate intracellular anticancer drug uptake and trigger cell apoptosis. Carboxymethyl-β-cyclodextrin sodium salt can be utilized for chiral separation in capillary electrophoresis, development of nanoscale drug carriers and nucleic acid transfection research .

HY-117710B

AD-35	Cholinesterase (ChE) Amyloid-β ERK TNF Receptor Interleukin Related	Neurological Disease
AD-35 is an orally active anti-Alzheimer's disease (AD) agent with moderate AChE inhibitory activity and metal ion chelating ability. AD-35 exhibits IC₅₀ values for AChE and BuChE of 793 nM and 31428 nM, respectively. AD-35 can form chelates with Cu²⁺ and Fe³⁺, but its chelating ability for Zn²⁺ is relatively weak. AD-35 can inhibit Aβ aggregation and disassemble the formed Aβ aggregates, and inhibit Aβ-induced ERK phosphorylation. AD-35 inhibits neuroinflammation in AD rat models and demonstrates a strong effect in improving cognitive function .

HY-B1159S

Nitroxoline-d4 8-Hydroxy-5-nitroquinoline-d₄; 5-Nitro-8-quinolinol-d₄	Bacterial Autophagy Antibiotic	Infection Cancer
Nitroxoline-d₄ is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe ²⁺ and Zn ²⁺ ions from the biofilm matrix .

HY-W585934

Fructose-phenylalanine Fru-Phe	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Fructose-phenylalanine (Fru-Phe) is a non-competitive angiotensin-converting enzyme (ACE) inhibitor (IC₅₀ =0.19 mM) with antioxidant activities. Fructose-phenylalanine forms a stable complex with Zn ²⁺ ions at the ACE active site, blocking the conversion of angiotensin I to II and thereby lowering blood pressure. Fructose-phenylalanine is promising for research of cardiovascular diseases .

HY-151494

CAII-IN-2	Carbonic Anhydrase	Cancer
CAII-IN-2 (compound 3g), a thiosemicarbazide derivative, is a potent, selective carbonic anhydrase-II (CA-II) inhibitor with an IC₅₀ value of 12.1 µM for bovine CA-II. CAII-IN-2 can be used in research of carbonic anhydrase related biological disorders .

HY-151493

CAII-IN-1	Carbonic Anhydrase	Cancer
CAII-IN-1 (compound 3n), a thiosemicarbazide derivative, is a potent, selective carbonic anhydrase-II (CA-II) inhibitor with an IC₅₀ value of 10.3 µM for bovine CA-II. CAII-IN-1 can be used in research of carbonic anhydrase related biological disorders .

HY-171029

C902	Amino Acid Derivatives	Others
C902 is a cysteine residue in the RAG1 protein, that binds to Zn ²⁺ ion and contributes to the DNA cleavage .

HY-129200

Aspergillomarasmine A	Endogenous Metabolite	Others
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators .

HY-W011060R

Cryptand 2.2.2 (Standard) 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Standard)	Biochemical Assay Reagents Reference Standards	Others
Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2 (HY-W011060). This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn ²⁺, Co ²⁺, Ni ²⁺, Cu ²⁺). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on .

HY-E70991

D-Ribulose-5-phosphate 3-Epimerase, Baker's yeast (S. cerevisiae)	Biochemical Assay Reagents	Metabolic Disease
D-Ribulose-5-phosphate 3-Epimerase, Baker's yeast (S. cerevisiae) (EC 5.1.3.1) is a metalloenzyme that primarily utilizes divalent zinc ions (Zn2+) for catalysis.

HY-E70958

Carboxypeptidase G, Pseudomonas sp.	Carboxypeptidase	Metabolic Disease
Carboxypeptidase G, Pseudomonas sp. (EC 3.4.17.11) is a lysosomal thiol-dependent protease that stepwise cleaves γ-glutamylpteroyl polyγ-glutamic acid to generate pteroyl-α-glutamic acid (folic acid) and free glutamic acid. Carboxypeptidase G is highly specific for the γ-glutamyl bond but not for the C-terminal amino acid of the leaving group. Carboxypeptidase G can be activated by Zn ²⁺ ions.

HY-W722245

Pyochelin	Endogenous Metabolite Bacterial	Infection
Pyochelin is a salicylate-based nonribosomal peptide siderophore produced by Pseudomonas aeruginosa. Pyochelin chelates Fe ³⁺ and transports it back into bacterial cells, providing the iron essential for bacterial survival. Pyochelin can also chelate other metals such as Zn ²⁺, Co ²⁺, and Ni ²⁺, which helps bacteria maintain intracellular metal ion homeostasis by chelating and excreting excess metals in response to toxic metal stress. Pyochelin can be used in studies related to Pseudomonas aeruginosa infection .

HY-113658

ts-SA	Endogenous Metabolite	Others
ts-SA is a carbonic anhydrase (CA) inhibitor with activity against seven human CA homologues. ts-SA can bind to the Zn(II) ion in the enzyme active site in a deprotonated form. The organic skeleton of ts-SA extends in the enzyme cavity and participates in multiple interactions with amino acid residues and water molecules. Due to its structural differences, the inhibitory performance of ts-SA is significantly better than that of another pyridine derivative. ts-SA exhibits low nanomolar inhibitory activity and is a multi-target CA inhibitor .

HY-165381

ZMC2	MDM-2/p53 Reactive Oxygen Species (ROS)	Cancer
ZMC2 is a thiosemicarbazone-class metal ion chelator and zinc ionophore with a human mutant p53 ^R175H binding K_a of 27.4 nM.ZMC2 binds Fe, Cu, Mn, Zn, and other transition metals.ZMC2 facilitates zinc transport across membranes.ZMC2 restores zinc binding to zinc-deficient p53 mutants, restoring wild-type structure and function, including site-specific DNA binding.ZMC2 generates reactive oxygen species (ROS).ZMC2 can be used for the research of cancer .

HY-180114

NSS-18	Cholinesterase (ChE) Monoamine Oxidase Amyloid-β Reactive Oxygen Species (ROS)	Neurological Disease
NSS-18 is a potent and reversible inhibitor of AChE and MAO-B, with IC₅₀ values of 1.53 and 1.51 μM respectively. NSS-18 can inhibit the self-aggregation of Aβ. NSS-18 inhibits the intracellular generation of ROS induced by Aβ. NSS-18 shows a moderate neuroprotective effect against 6-OHDA (HY-B1081)-induced neurotoxicity. NSS-18 can form chelates with metal ions such as Cu²⁺, Fe³⁺, and Zn²⁺, with the strongest chelation being with Cu²⁺. NSS-18 can be used for the study of Alzheimer's disease .

Art. -Nr.	Produktname	Type

HY-119287

TSQ 5 Publications Verification	Fluorescent Dyes
TSQ is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence (Ex/Em = 334/495 nm) .

HY-158779

Sulfane sulfur probe 4 SSP4	Fluorescent Dyes
Sulfane sulfur probe 4 (SSP4) is a fluorescent probe used to detect sulfane sulfur species (E_x/E_m=494/515 nm). Sulfane sulfur probe 4 exhibits high sensitivity in detecting sulfane sulfur, even in the presence of other substances such as homocysteine, methionine, cysteine, glutathione, N-acetyl-L-cysteine, glycine, tyrosine, tryptophan, arginine, and metal ions (Fe ²⁺, Fe ³⁺, Mg ²⁺, Ca ²⁺, and Zn ²⁺) .

Sulfane sulfur probe 4

SSP4

Fluorescent Dyes

Sulfane sulfur probe 4 (SSP4) is a fluorescent probe used to detect sulfane sulfur species (E_x/E_m=494/515 nm). Sulfane sulfur probe 4 exhibits high sensitivity in detecting sulfane sulfur, even in the presence of other substances such as homocysteine, methionine, cysteine, glutathione, N-acetyl-L-cysteine, glycine, tyrosine, tryptophan, arginine, and metal ions (Fe ²⁺, Fe ³⁺, Mg ²⁺, Ca ²⁺, and Zn ²⁺) .

HY-DY1055

TSQ (solution)	Fluorescent Dyes
TSQ (solution) is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn ²⁺ in the presence of Ca ²⁺ and Mg ²⁺ to produce blue fluorescence (Ex/Em = 334/495 nm) . Solvent and concentration: DMSO: 10 mM

Art. -Nr.	Produktname	Type

HY-W127776

Zn(Ⅱ)-EDTA disodium tetrahydrate Ethylenediaminetetraacetic acid zinc disodium tetrahydrate	Biochemical Assay Reagents
Zn(II)-EDTA (Ethylenediaminetetraacetic acid zinc) disodium tetrahydrate is a coordinating agent. Zn(II)-EDTA disodium tetrahydrate coordinates with Zn ²⁺ to modify its solvated structure, provides pre-synthesized EDTA-Zn complexes that release Zn ²⁺ to repair zinc anode defects under interfacial electric field, adsorbs onto zinc anode surface to block oxygen and water molecules, inhibits corrosion and hydrogen evolution reactions, promotes uniform Zn ²⁺ deposition, suppresses zinc dendrite formation, and modulates the hydrogen bonding network within the electrolyte. Zn(II)-EDTA disodium tetrahydrate acts as an electrolyte additive to enhance reversibility and stability of zinc anodes in aqueous zinc-ion batteries .

Zn(Ⅱ)-EDTA disodium tetrahydrate

Ethylenediaminetetraacetic acid zinc disodium tetrahydrate

Biochemical Assay Reagents

Zn(II)-EDTA (Ethylenediaminetetraacetic acid zinc) disodium tetrahydrate is a coordinating agent. Zn(II)-EDTA disodium tetrahydrate coordinates with Zn ²⁺ to modify its solvated structure, provides pre-synthesized EDTA-Zn complexes that release Zn ²⁺ to repair zinc anode defects under interfacial electric field, adsorbs onto zinc anode surface to block oxygen and water molecules, inhibits corrosion and hydrogen evolution reactions, promotes uniform Zn ²⁺ deposition, suppresses zinc dendrite formation, and modulates the hydrogen bonding network within the electrolyte. Zn(II)-EDTA disodium tetrahydrate acts as an electrolyte additive to enhance reversibility and stability of zinc anodes in aqueous zinc-ion batteries .

HY-NP009

α-Lactalbumin	Biochemical Assay Reagents
α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca ²⁺, Mg ²⁺, Mn ²⁺, Na ⁺, K ⁺ and Zn ²⁺ ions; among these, Ca ²⁺ binding enhances protein stability, while Zn ²⁺ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions .

α-Lactalbumin

Biochemical Assay Reagents

α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca ²⁺, Mg ²⁺, Mn ²⁺, Na ⁺, K ⁺ and Zn ²⁺ ions; among these, Ca ²⁺ binding enhances protein stability, while Zn ²⁺ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions .

HY-W011060

Cryptand 2.2.2 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane	Biochemical Assay Reagents
Cryptand 2.2.2 (4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane) is a metal ion chelator. Cryptand 2.2.2 forms stable mononuclear, protonated and dinuclear complexes with copper (II) ions; forms protonated complexes with hydrogen ions; and also forms stable complexes with Zn ²⁺, Co ²⁺, Ni ²⁺, Cd ²⁺, Hg ²⁺ and Pb ²⁺ ions. Cryptand 2.2.2 can be used for the preparation of nanoparticles, transition metal compounds, etc.

Cryptand 2.2.2

4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane

Biochemical Assay Reagents

Cryptand 2.2.2 (4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane) is a metal ion chelator. Cryptand 2.2.2 forms stable mononuclear, protonated and dinuclear complexes with copper (II) ions; forms protonated complexes with hydrogen ions; and also forms stable complexes with Zn ²⁺, Co ²⁺, Ni ²⁺, Cd ²⁺, Hg ²⁺ and Pb ²⁺ ions. Cryptand 2.2.2 can be used for the preparation of nanoparticles, transition metal compounds, etc.

HY-Y0850U5

PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) Polyvinyl alcohol (Mw 27000, 98-99% hydrolyzed, ~600 polymerization); Poly(Ethenol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)	Biochemical Assay Reagents
PVA (Polyvinyl alcohol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) is a nonionic ethanol homopolymer with hydrophilicity, water solubility and biodegradability. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) exhibits biocompatibility, non-toxicity and non-carcinogenicity, as well as antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can serve as a solubilizer, stabilizer, mucoadhesive agent and sustained-release agent, and has a synergistic solubilizing effect on voriconazole/sulfobutyl ether β-cyclodextrin complexes. By stabilizing such complexes, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) forms freeze-thaw hydrogels with high mucoadhesion, sustained drug release and ex vivo corneal permeability. When compounded with hyaluronic acid hydrogels, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) supports chondrocyte growth in vitro, and also forms complexes with Cu ²⁺, Co ²⁺, Ni ²⁺ and Zn ²⁺ ions. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can be used in studies related to fungal keratitis, bacterial infections and fungal infections .

PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)

Polyvinyl alcohol (Mw 27000, 98-99% hydrolyzed, ~600 polymerization); Poly(Ethenol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)

Biochemical Assay Reagents

PVA (Polyvinyl alcohol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) is a nonionic ethanol homopolymer with hydrophilicity, water solubility and biodegradability. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) exhibits biocompatibility, non-toxicity and non-carcinogenicity, as well as antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can serve as a solubilizer, stabilizer, mucoadhesive agent and sustained-release agent, and has a synergistic solubilizing effect on voriconazole/sulfobutyl ether β-cyclodextrin complexes. By stabilizing such complexes, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) forms freeze-thaw hydrogels with high mucoadhesion, sustained drug release and ex vivo corneal permeability. When compounded with hyaluronic acid hydrogels, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) supports chondrocyte growth in vitro, and also forms complexes with Cu ²⁺, Co ²⁺, Ni ²⁺ and Zn ²⁺ ions. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can be used in studies related to fungal keratitis, bacterial infections and fungal infections .

HY-W011060R

Cryptand 2.2.2 (Standard) 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Standard)	Biochemical Assay Reagents
Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2 (HY-W011060). This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn ²⁺, Co ²⁺, Ni ²⁺, Cu ²⁺). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on .

Cryptand 2.2.2 (Standard)

4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Standard)

Biochemical Assay Reagents

Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2 (HY-W011060). This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn ²⁺, Co ²⁺, Ni ²⁺, Cu ²⁺). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on .

Art. -Nr.	Produktname	Target	Research Area

HY-P2516

Tau Peptide (275-305) (Repeat 2 domain)	Tau Protein	Neurological Disease
Tau Peptide (275-305) (Repeat 2 domain) is the Alzheimer's Tau fragment R2, corresponding to the second repeat unit of the microtubule-binding domain, which is believed to be pivotal to the biochemical properties of full tau protein. Tau Peptide (275-305) specifically coordinates with group IIB metal ions (Zn²⁺, Cd²⁺, Hg²⁺), which can induce their conformational changes and significantly promote their pathological accumulation. Tau Peptide (275-305) can be used to study the role of heavy metals in neurodegenerative diseases .

Art. -Nr.	Produktname

HY-K0256

Chelating Agarose (IDA) 6FF
MCE Chelating Agarose (IDA) 6FF allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

HY-K0255

IMAC Agarose (NTA) 6FF
MCE IMAC Agarose (NTA) 6FF is prepared by covalently coupling tetradentate nitrilotriacetic acid (NTA) to an agarose matrix. It features high binding capacity, excellent specificity, and superior ligand stability. The resin allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

IMAC Agarose (NTA) 6FF

MCE IMAC Agarose (NTA) 6FF is prepared by covalently coupling tetradentate nitrilotriacetic acid (NTA) to an agarose matrix. It features high binding capacity, excellent specificity, and superior ligand stability. The resin allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

Art. -Nr.	Produktname	Category	Target	Chemical Structure

HY-129200

Aspergillomarasmine A	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators .

HY-W722245

Pyochelin	Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Phenols Source Classification	Endogenous Metabolite Bacterial
Pyochelin is a salicylate-based nonribosomal peptide siderophore produced by Pseudomonas aeruginosa. Pyochelin chelates Fe ³⁺ and transports it back into bacterial cells, providing the iron essential for bacterial survival. Pyochelin can also chelate other metals such as Zn ²⁺, Co ²⁺, and Ni ²⁺, which helps bacteria maintain intracellular metal ion homeostasis by chelating and excreting excess metals in response to toxic metal stress. Pyochelin can be used in studies related to Pseudomonas aeruginosa infection .

Art. -Nr.	Produktname	Chemical Structure

HY-B1159S

Nitroxoline-d4
Nitroxoline-d₄ is the deuterium labeled Nitroxoline. Nitroxoline is an antibiotic that has proven to be very effective at combating biofilm infections. Nitroxoline functions by chelating Fe ²⁺ and Zn ²⁺ ions from the biofilm matrix .

Art. -Nr.	Produktname		Classification

HY-180114

NSS-18		Alkynes
NSS-18 is a potent and reversible inhibitor of AChE and MAO-B, with IC₅₀ values of 1.53 and 1.51 μM respectively. NSS-18 can inhibit the self-aggregation of Aβ. NSS-18 inhibits the intracellular generation of ROS induced by Aβ. NSS-18 shows a moderate neuroprotective effect against 6-OHDA (HY-B1081)-induced neurotoxicity. NSS-18 can form chelates with metal ions such as Cu²⁺, Fe³⁺, and Zn²⁺, with the strongest chelation being with Cu²⁺. NSS-18 can be used for the study of Alzheimer's disease .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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Bemerkungen

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE-Kits

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Zn ion

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

MCE-Kits

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products