2,5-Dihydroxyterephthalic acid
Based on 1 Customer Validation
2,5-Dihydroxyterephthalic acid is a carboxylic acid ligand with antioxidant properties, which serves as a building block for Zn2+-based metal-organic frameworks (MOFs). 2,5-Dihydroxyterephthalic acid forms stable coordination bonds with transition metal ions, inhibits metal center-water coordination to prevent MOF fluorescence quenching, and enhances the hydrophilicity of MOFs. 2,5-Dihydroxyterephthalic acid acts as a pharmaceutical intermediate to synthesize 2,5-dihydroxyterephthalamide derivatives. 2,5-Dihydroxyterephthalic acid is applicable to relevant research in fields such as organic synthesis.
For research use only. We do not sell to patients.
- Purity : 99.97%
- CAS No.: 610-92-4
- Formula: C8H6O6
- Molecular Weight:198.13
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
TNF-α |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 610-92-4
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Appearance Solid
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Molecular Weight 198.13
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Formula C8H6O6
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Color Light yellow to green yellow
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SMILES
O=C(O)C1=CC(O)=C(C=C1O)C(=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (504.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang J, et al. Zn(ii)-based metal-organic frameworks with tailored architectures: optimizing fluorescence performance for cell imaging and cancer therapy. RSC advances. 2026 May 13;16(28):25892-25901. [Content Brief]
[2]. Song Q, et al. Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry. 2018 Dec 15;26(23-24):6115-6127. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.0472 mL | 25.2360 mL | 50.4719 mL | 126.1798 mL |
| 5 mM | 1.0094 mL | 5.0472 mL | 10.0944 mL | 25.2360 mL | |
| 10 mM | 0.5047 mL | 2.5236 mL | 5.0472 mL | 12.6180 mL | |
| 15 mM | 0.3365 mL | 1.6824 mL | 3.3648 mL | 8.4120 mL | |
| 20 mM | 0.2524 mL | 1.2618 mL | 2.5236 mL | 6.3090 mL | |
| 25 mM | 0.2019 mL | 1.0094 mL | 2.0189 mL | 5.0472 mL | |
| 30 mM | 0.1682 mL | 0.8412 mL | 1.6824 mL | 4.2060 mL | |
| 40 mM | 0.1262 mL | 0.6309 mL | 1.2618 mL | 3.1545 mL | |
| 50 mM | 0.1009 mL | 0.5047 mL | 1.0094 mL | 2.5236 mL | |
| 60 mM | 0.0841 mL | 0.4206 mL | 0.8412 mL | 2.1030 mL | |
| 80 mM | 0.0631 mL | 0.3154 mL | 0.6309 mL | 1.5772 mL | |
| 100 mM | 0.0505 mL | 0.2524 mL | 0.5047 mL | 1.2618 mL |
2,5-Dihydroxyterephthalic acid Related Classifications
HY-W004616 Related Classifications
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Keywords
- 2,5-Dihydroxyterephthalic acid
- 610-92-4
- MOFs
- Drug Intermediate
- TNF Receptor
- Metal-Organic Frameworks
- Drug Iintermediate
- Tumor Necrosis Factor Receptor
- TNFR
- cervical adenocarcinoma
- Zn(II)-based metal-organic frameworks
- Aβ1-42
- lung carcinoma
- SH-SY5Y cells
- RatAChE
- neuroblastoma
- A549 cells
- BV-2 microglial cells
- HeLa cells
- Inhibitor
- inhibitor
- inhibit