234075-45-7
234075-45-7
Chemical Structure
Phen Green SK diacetate (5/6-mixture)
Synonym(s): PGSK diacetate (5/6-mixture)
- CAS No.: 234075-45-7
- Formula:C37H21Cl2N3O8
- Molecular Weight:706.48
IUPAC Name: 5-((1,10-phenanthrolin-5-yl)carbamoyl)-2',7'-dichloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate compound with 6-((1,10-phenanthrolin-5-yl)carbamoyl)-2',7'-dichloro-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate (1:1)
InChIKey: GWNKLUVXFBYALG-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(C3(C4=C(OC5=C3C=C(Cl)C(OC(C)=O)=C5)C=C(OC(C)=O)C(Cl)=C4)OC2=O)C=C1)NC6=C7C=CC=NC7=C8N=CC=CC8=C6.CC(OC(C(Cl)=C9)=CC%10=C9C%11(C%12=C(C(O%11)=O)C=CC(C(NC%13=C%14C=CC=NC%14=C%15N=CC=CC%15=C%13)=O)=C%12)C(C=C%16Cl)=C(O%10)C=C%16OC(C)=O)=O
Biological Activity: Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture)) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, Zn2+, etc. Phen green SK (PGSK) diacetate chelates Fe2+, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Phen Green SK diacetate (5/6-mixture) | 95.56% | Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture)) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, Zn2+, etc. Phen green SK (PGSK) diacetate chelates Fe2+, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively. | ||||||||||||||||||||
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5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester | 96.38% | 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester (cDCFDASE) is a fluorescent probe. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester can be used to evaluate the intracellular pH (pHin) of living cells at a medium pH (pHex). | ||||||||||||||||||||
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5(6)-Carboxy-2',7'-dichlorofluorescein | 99.03% | 5 (6)-Carboxy-2',7'-dichlorofluorescein is a fluorescent probe substrate that acts on MRP1 and MRP3/Mrp3, passively diffuses across cell membranes, and is actively effluxed by MRP1 in MRP1-positive cells. 5 (6)-Carboxy-2',7'-dichlorofluorescein is transported across membranes in an ATP-dependent manner, but does not stimulate ATPase activity. | ||||||||||||||||||||
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5(6)-CFDA | 98.75% | 5(6)-CFDA is a common aliphatic luciferin-line organism. CFDA conducts free diffusion into cells, and then it is hydrolyzed into carboxyl fluorescein (CF) by intracellular non-specific lipase. CF containing portion contains an additional negative charge so that it is better retained in cells, compared to fluorescein dyes. | ||||||||||||||||||||
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CFDA-SE | 97.21% | CFDA-SE is a fluorescent dye that can penetrate the cell membrane. It can react with the free amine group in the cytoskeleton protein inside the cell, and finally form a protein complex with fluorescence. After entering the cell, CFDA-SE locates in the cell membrane, cytoplasm and nucleus, and the fluorescence staining is strongest in the nucleus. CFDA-SE dye can be uniformly inherited by the cells with cell division and proliferation, and its attenuation is proportional to the number of cell divisions. This phenomenon can be detected and analyzed by flow cytometry under the excitation light of 488 nm, and can be used to detect the proliferation of cells. | ||||||||||||||||||||
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5(6)-Carboxy-2',7'-dichlorofluorescein diacetate | 97.5% | 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is a fluorescein-based reactive oxygen species (ROS) probe and also a MRP2 substrate. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate serves as a substrate for intracellular esterases, which cleave its acetate groups to generate a fluorescent product capable of detecting intracellular ROS. 5 (6)-Carboxy-2',7'-dichlorofluorescein diacetate is ATP-dependent and is transported via a single MRP2 binding site; it competes with LTC4 for MRP2 binding sites and inhibits MRP2-mediated LTC4 transport (Ex/Em = 496/525 nm). | ||||||||||||||||||||
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Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) | 95.30% | Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) is a fluorescent probe used for intracellular pH measurement. The detection wavelengths of Carboxy SNARF, acetoxymethyl ester are Ex/Em = 540/590 nm and 540/650 nm, with an excitation wavelength of 540 nm. Emission signals at 590 nm and 650 nm are recorded simultaneously, and the ratio of these emission signals yields a linear measurement of intracellular pH. | ||||||||||||||||||||
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Calcium Green 1AM | 95.0% | Calcium Green 1AM is a cell-permeable fluorescent calcium indicator dye. Calcium Green 1AM detects intracellular calcium signals and reports calcium transients in spontaneously rhythmic tissues as relative fluorescence changes. Calcium Green 1AM is excited by an argon laser, captures emission light at 488 nm, and is detected using an epifluorescence illumination system on an upright microscope equipped with a fluorescein filter block. | ||||||||||||||||||||
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FG 488 BAPTA-2 AM | FG 488 BAPTA-2 AM is a calcium-specific reporter dye. FG 488 BAPTA-2 AM can be used to detect calcium concentration. | |||||||||||||||||||||
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CellTracker Orange CMRA Dye (5/6-mixture) | 98.0% | CellTracker Orange CMRA Dye is a fluorescent dye. CellTracker Orange CMRA Dye can be used for cell imaging and monitoring the movement and location of cells. | ||||||||||||||||||||
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Calcium Green BAPTA-2 AM | Calcium Green BAPTA-2 AM is a fluorescent calcium indicator. | |||||||||||||||||||||
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References
- [1]. Petrat F, et al. Determination of the chelatable iron pool of isolated rat hepatocytes by digital fluorescence microscopy using the fluorescent probe, phen green SK. Hepatology. 1999;29(4):1171-1179. [Content Brief]
- [2]. Li L, et al. NDRG1 alleviates Erastin-induced ferroptosis of hepatocellular carcinoma. BMC Cancer. 2025 Mar 21;25(1):522. [Content Brief]
- [3]. Xu Z, et al. Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis. J Ethnopharmacol. 2024 Nov 15;334:118582. [Content Brief]
