295-37-4
Chemical Structure
Cyclam
- CAS No.: 295-37-4
- Formula:C10H24N4
- Molecular Weight:200.33
IUPAC Name: 1,4,8,11-tetraazacyclotetradecane
InChIKey: MDAXKAUIABOHTD-UHFFFAOYSA-N
SMILES: N1CCNCCCNCCNCCC1
Biological Activity: Cyclam is a macrocyclic polyamine that can serve as a high-affinity chelator for Cu2+ and a CXCR4-targeting motif. Cyclam is the CXCR4-binding unit of the CXCR4 antagonist Plerixafor (AMD3100) (HY-10046). Cyclam-based macrocyclic compounds possess anti-HIV activity and can mobilize stem cells from the bone marrow. Cyclam can be used in research on ovarian cancer with high CXCR4 expression, as well as in the development of Cu2+ sensors and lanthanide luminescent bioprobes[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Cyclam | 98.0% | Cyclam is a macrocyclic polyamine that can serve as a high-affinity chelator for Cu2+ and a CXCR4-targeting motif. Cyclam is the CXCR4-binding unit of the CXCR4 antagonist Plerixafor (AMD3100) (HY-10046). Cyclam-based macrocyclic compounds possess anti-HIV activity and can mobilize stem cells from the bone marrow. Cyclam can be used in research on ovarian cancer with high CXCR4 expression, as well as in the development of Cu2+ sensors and lanthanide luminescent bioprobes. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Huang Y, et al. Single Cyclam Scaffold-Integrated NIR Probe for CXCR4 Targeting and Copper Sensing to Evaluate Cuproptosis-Inducing Ionophores in Ovarian Cancer. Sensors and Actuators B: Chemical. 2026 Sep 13:140899.
- [2]. Dohyun Moon, Sunghwan Jeon, Jong-Ha Choi, Crystal structure, endo/exodentate conformations, spectroscopic properties, and Hirshfeld surface analysis of two constrained cyclam compounds with bromides and hydrates, Journal of Molecular Structure, Volume 1232, 2021, 130011, ISSN 0022-2860.
- [3]. Mendy J, et al. Cationic Biphotonic Lanthanide Luminescent Bioprobes Based on Functionalized Cross-Bridged Cyclam Macrocycles. Chemphyschem : a European journal of chemical physics and physical chemistry. 2020 May 18;21(10):1036-1043.
