α-Lactalbumin
Based on 1 Customer Validation
α-Lactalbumin is a globular whey protein that exists in milk. α-Lactalbumin binds Ca2+, Mg2+, Mn2+, Na+, K+ and Zn2+ ions; among these, Ca2+ binding enhances protein stability, while Zn2+ binding reduces stability and induces aggregation. α-Lactalbumin forms amyloid fibrils, amorphous aggregates, nanoparticles and nanotubes depending on external conditions. α-Lactalbumin exhibits bactericidal and antiviral activities. α-Lactalbumin has anxiolytic and antidepressant activities, and its effects are enhanced under stress conditions.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 9051-29-0
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Acylated and esterified derivatives of bovine α-Lactalbumin possess broad-spectrum antiviral activity against HIV-1, HIV-2, HSV-1, cytomegalovirus, and avian influenza H5N1[1].
α-Lactalbumin is a component of lactose synthase, an enzyme system, which consists of galactosyltransferase (GT) and α-Lactalbumin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male, 2.5 months old)[3]
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Dosage:18.8 g/100 g (diet content)
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Administration:dietary; ad libitum daily; 30 days
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Result:Reduced weight gain significantly compared to casein-fed mice.
Decreased aggressive behaviour to 29% in group social tests.
Spent less time (124 s) and had lower mobility (102 s) in the light compartment of the light-dark box test.
Travelled a longer distance (1235 mm) in protected zones of the elevated-plus maze.
Showed longer total duration (15.4) and higher total frequency (8.8) of freezing behaviour near a new object in the open-field test.
Chemical Information
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CAS No. 9051-29-0
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Appearance Solid
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Color White to off-white
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SMILES
[a-Lactalbumin]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Permyakov EA, et al. α-Lactalbumin, Amazing Calcium-Binding Protein. Biomolecules. 2020;10(9):1210. Published 2020 Aug 20. [Content Brief]
[2]. Hallgren O, et al. Apoptosis and tumor cell death in response to HAMLET (human alpha-lactalbumin made lethal to tumor cells). Adv Exp Med Biol. 2008;606:217-240. [Content Brief]
[3]. Vekovischeva OY, et al. The effects of native whey and α-lactalbumin on the social and individual behaviour of C57BL/6J mice. Br J Nutr. 2013;110(7):1336-1346. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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