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Results for "

anthraquinone derivative

" in MedChemExpress (MCE) Product Catalog:

29

Inhibitors & Agonists

20

Natural
Products

1

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14393
    Emodin
    Maximum Cited Publications
    39 Publications Verification

    Frangula emodin

    		 SARS-CoV Casein Kinase Autophagy 11β-HSD Cancer
    Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .
    Emodin
  • HY-N0108
    Physcion
    5+ Cited Publications

    Parietin; Rheochrysidin

    		 Bacterial Toll-like Receptor (TLR) NF-κB Apoptosis Autophagy Antibiotic Infection Inflammation/Immunology Cancer
    Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC50 and Kd values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the <>bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells .
    Physcion
  • HY-135954A
    PDK4-IN-1 hydrochloride
    3 Publications Verification

    		 PDHK Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 hydrochloride potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 hydrochloride has antidiabetic, anticancer and anti-allergic activity .
    PDK4-IN-1 hydrochloride
  • HY-120601
    Alizarin Red S sodium
    5+ Cited Publications

    ARS sodium

    		 Fluorescent Dye Others
    Alizarin Red S sodium is an anthraquinone derivative dye. When combined with cations such as calcium ions, the functional group of Alizarin Red S sodium can form a coordination bond with the cation through the oxygen atom to show orange-red fluorescence. Alizarin Red S sodium can be used for screening of calcium compounds in synovial fluid and detecting osteoblast differentiation, and can also be used for bone staining in mice. Excitation/emission wavelength: 500/570 nm .
    Alizarin Red S sodium
  • HY-135954
    PDK4-IN-1
    3 Publications Verification

    		 PDHK Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    PDK4-IN-1 is an anthraquinone derivative and a potent and orally active pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 value of 84 nM. PDK4-IN-1 potently represses cellular transformation and cellular proliferation and induces apoptosis. PDK4-IN-1 has antidiabetic, anticancer and anti-allergic activity .
    PDK4-IN-1
  • HY-120601A
    Alizarin Red S
    5+ Cited Publications

    ARS

    		 Fluorescent Dye Others
    Alizarin Red S (ARS) is an anthraquinone derivative dye. When combined with cations such as calcium ions, the functional group of Alizarin Red S can form a coordination bond with the cation through the oxygen atom to show orange-red fluorescence. Alizarin Red S can be used for screening of calcium compounds in synovial fluid and detecting osteoblast differentiation, and can also be used for bone staining in mice. Excitation/emission wavelength: 500/570 nm .
    Alizarin Red S
  • HY-N0311
    Emodin-8-glucoside
    2 Publications Verification

    		 Aldose Reductase Topoisomerase SOD p38 MAPK Neurological Disease Inflammation/Immunology
    Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC50s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier .
    Emodin-8-glucoside
  • HY-N6013
    Aloin (mixture of A&B)

    		MMP Proteasome Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Bacterial Fungal Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .
    Aloin (mixture of A&B)
  • HY-B0738
    Dithranol

    Anthralin

    		 DNA/RNA Synthesis Inflammation/Immunology
    Dithranol (Anthralin) is an anthraquinone derivative, with potent anti-psoriatic effects. Dithranol can inhibit DNA replication and repair .
    Dithranol
  • HY-N8022
    Lucidin primeveroside

    Lucidin 3-O-β-primeveroside

    		 Biochemical Assay Reagents Cancer
    Lucidin primeveroside (Lucidin 3-O-β-primeveroside) is an anthraquinone derivative present in madder root, which has been used as a coloring agent and food additive. Lucidin primeveroside can be metabolically converted to genotoxic compound Lucidin, which subsequently forms lucidin-specific DNA adducts .
    Lucidin primeveroside
  • HY-14393R
    Emodin (Standard)
    Maximum Cited Publications
    39 Publications Verification

    Frangula emodin (Standard)

    		 Reference Standards SARS-CoV Casein Kinase Autophagy 11β-HSD Cancer
    Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .
    Emodin (Standard)
  • HY-133860
    Chrysoobtusin

    		Drug Derivative Others
    Chrysoobtusin is an anthraquinone derivative isolated from Semen Cassiae. Semen Cassiae has long been used to protect liver, brighten eyes, and relieve constipation .
    Chrysoobtusin
  • HY-14393S
    Emodin-d4

    Frangula emodin-d4

    		 Isotope-Labeled Compounds SARS-CoV Casein Kinase Autophagy 11β-HSD Cancer
    Emodin-d4 is the deuterium labeled Emodin. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .
    Emodin-d4
  • HY-N6013R
    Aloin (mixture of A&B) (Standard)

    		Reference Standards Proteasome MMP Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Fungal Bacterial Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Aloin (mixture of A&B) (Standard) is the analytical standard of Aloin (mixture of A&B) (HY-N6013). This product is intended for research and analytical applications. Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .
    Aloin (mixture of A&B) (Standard)
  • HY-W353602
    Aleoe-emodin triacetate

    		Drug Derivative Others
    Aleoe-emodin triacetate is an Anthraquinone (HY-N0354) derivative, and can be isolated from leaves of Kniphofia foliosa .
    Aleoe-emodin triacetate
  • HY-135770
    9-Dehydroxyeurotinone

    		Endogenous Metabolite Cancer
    9-Dehydroxyeurotinone is an anthraquinone derivative that can be found in Eurotium rubrum. 9-Dehydroxyeurotinone shows cytotoxicity with an IC50 value of 25 µg/mL for SW1990 cells .
    9-Dehydroxyeurotinone
  • HY-B0738R
    Dithranol (Standard)

    Anthralin (Standard)

    		 Reference Standards DNA/RNA Synthesis Inflammation/Immunology
    Dithranol (Standard) is the analytical standard of Dithranol. This product is intended for research and analytical applications. Dithranol (Anthralin) is an anthraquinone derivative, with potent anti-psoriatic effects. Dithranol can inhibit DNA replication and repair .
    Dithranol (Standard)
  • HY-N14807
    Neobulgarone A

    		Fungal Infection
    Neobulgarone A is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone A can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity .
    Neobulgarone A
  • HY-N14808
    Neobulgarone B

    		Fungal Infection
    Neobulgarone B is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone B can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity .
    Neobulgarone B
  • HY-N14812
    Neobulgarone E

    		Fungal Infection
    Neobulgarone E is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone E can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity .
    Neobulgarone E
  • HY-N14810
    Neobulgarone D

    		Fungal Infection
    Neobulgarone D is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone D can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity .
    Neobulgarone D
  • HY-N14809
    Neobulgarone C

    		Fungal Infection
    Neobulgarone C is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone C can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity .
    Neobulgarone C
  • HY-N0311R
    Emodin-8-glucoside (Standard)

    		Reference Standards Aldose Reductase Topoisomerase SOD p38 MAPK Neurological Disease Inflammation/Immunology
    Emodin-8-glucoside (Standard) is the analytical standard of Emodin-8-glucoside. This product is intended for research and analytical applications. Emodin-8-glucoside is an anthraquinone derivative that can be isolated from Aloe vera. Emodin-8-glucoside is the inhibitor for MAPK with an inhibition constant of 430.14 pM. Emodin-8-glucoside exhibits moderate inhibitory activity against rat lens aldose reductase (ALAR) and topoisomerases II with IC50s of 14.4 μM and 66 μM. Emodin-8-glucoside exhibits antioxidant, anti-inflammatory and anti-fibrotic activities. Emodin-8-glucoside can cross the blood brain barrier .
    Emodin-8-glucoside (Standard)
  • HY-N17416
    ω-Hydroxydigitoemodin

    		Cholinesterase (ChE) Neurological Disease
    ω-Hydroxydigitoemodin is an anthraquinone derivative with anti-acetylcholinesterase activity, found in the marine fungus Trichoderma harzianum XS-20090075 .
    ω-Hydroxydigitoemodin
  • HY-N18716
    Senna leaf extract

    		Others Others
    Senna Leaf Extract is the main raw material of Cassia angustifolia Vahl. Its main active ingredients are Sennoside A and B, and contain rhein, aloe-emodin, chrysophanol and other anthraquinones Derivatives and other glycosides.
    Senna leaf extract
  • HY-N14814
    Neobulgarone F

    		Fungal Infection
    Neobulgarone F is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone F can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity .
    Neobulgarone F
  • HY-N17915
    2-Methyl-3,5,6-trihydroxyanthraquinone

    		Others Others
    2-Methyl-3,5,6-trihydroxyanthraquinone (compound 6) is an anthraquinone found in cell suspension cultures of Morinda citrifolia .
    2-Methyl-3,5,6-trihydroxyanthraquinone
  • HY-179616
    AT-9

    		DNA Alkylator/Crosslinker Drug Derivative Topoisomerase Cancer
    AT-9 is an anthraquinone-triazene derivative. AT-9 exhibits strong DNA intercalation ability. AT-9 can also interact with Topo IIA. AT-9 exhibits anticancer activity against non-small cell lung cancer and cervical cancer .
    AT-9
  • HY-177208
    BW-AQ-113

    		Drug Derivative MDM-2/p53 Apoptosis Bcl-2 Family Caspase Cancer
    BW-AQ-113 is an Anthraquinone (HY-N0354) derivative. BW-AQ-113 can specifically degrade MDM2 and activate the p53 pathway. BW-AQ-113 can induce apoptosis by downregulating anti-apoptotic gene Bcl-2 and regulating pro-apoptotic gene Bax and CASP3. BW-AQ-113 can be used for research of p53 wild-type hematological malignancies .
    BW-AQ-113

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