1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. Dithranol

Dithranol (Synonyms: Anthralin)

Cat. No.: HY-B0738
Handling Instructions

Dithranol (Anthralin) is an anthraquinone derivative, with potent anti-psoriatic effects. Dithranol can inhibit DNA replication and repair.

For research use only. We do not sell to patients.

Dithranol Chemical Structure

Dithranol Chemical Structure

CAS No. : 1143-38-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 73 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 73 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 66 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Dithranol (Anthralin) is an anthraquinone derivative, with potent anti-psoriatic effects. Dithranol can inhibit DNA replication and repair[1][2].

In Vitro

Dithranol (1.1 μM) inhibits replication in T98G cells by 50%[2].
Dithranol (0.1-0.5 μg/mL; 2-4 hours) increases the mRNA production of interleukin-10 receptors in a concentration dependent manner in HaCaT cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[3]

Cell Line: HaCaT cells
Concentration: 0.1 μg/mL, 0.25 μg/mL, 0.5 μg/mL
Incubation Time: 2 hours, 4 hours
Result: Increased the mRNA production of interleukin-10 receptors in HaCaT cells.
Clinical Trial
Molecular Weight

226.23

Formula

C14H10O3

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (44.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4203 mL 22.1014 mL 44.2028 mL
5 mM 0.8841 mL 4.4203 mL 8.8406 mL
10 mM 0.4420 mL 2.2101 mL 4.4203 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 1 mg/mL (4.42 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 1 mg/mL (4.42 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (4.42 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Dithranol
Cat. No.:
HY-B0738
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