41 Results for "

antitussive activity

" in MedChemExpress (MCE) Product Catalog:
Products (41)

41 Results for "antitussive activity" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-N0808
CAS No.: 76-22-2
Synonyms: (±)-Camphor
Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .
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2
2 Cited Publications
Cat. No.: HY-13716
CAS No.: 128-62-1
Purity:  99.98%
Synonyms: (S,R)-Noscapine
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .
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2
2 Cited Publications
Cat. No.: HY-13716A
CAS No.: 912-60-7
Purity:  99.87%
Synonyms: (S,R)-Noscapine hydrochloride
Noscapine ((S,R)-Noscapine) hydrochloride is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine hydrochloride exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine hydrochloride disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine hydrochloride possesses anticancer, neuroprotective, anti-inflammatory activities, and can crosse the blood-brain barrier .
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1
1 Cited Publications
Cat. No.: HY-N0829
CAS No.: 10376-48-4
Shionone is the major triterpenoid isolated from Aster tataricus, has anti-tussive, anti-inflammatory activities . Shionone possesses a unique six-membered tetracyclic skeleton and 3-oxo-4-monomethyl structure .
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Cat. No.: HY-B1551
CAS No.: 104-31-4
Synonyms: Benzononatine
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Benzonatate (Benzononatine) is an orally active and non-narcotic peripheral antitussive agent. Benzonatate is a reversible voltage-gated Na + channels inhibitor. Benzonatate dampens the activity of cough stretch receptors .
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Cat. No.: HY-N1255
CAS No.: 6451-73-6
Synonyms: (-)-Scoulerine; Discretamine
Scoulerine ((-)-Scoulerine; Discretamine) hydrochloride is a multi-target inhibitor with anti-tumor and antioxidant activities. Scoulerine mainly targets the PI3K/Akt/mTOR signaling axis and α1D-adrenergic receptor, disrupts microtubule structure, and induces cell cycle arrest and apoptosis. Scoulerine effectively inhibits mitochondrial dehydrogenase activity, targets GABA receptors and BACE1, and suppresses the proliferation, migration, invasion, epithelial-mesenchymal transition and stem cell properties of cancer cells. Scoulerine also exhibits multiple pharmacological activities including anti-Plasmodium falciparum, antibacterial, antiemetic and antitussive effects, and regulates endoplasmic reticulum stress and mitochondrial function (modulates Bax, Bcl-2 and cytochrome c). Scoulerine is applicable to research related to leukemia, ovarian cancer, and colorectal cancer .
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Cat. No.: HY-N1377
CAS No.: 10176-66-6
Synonyms: Lysionotin
Nevadensin (Lysionotin), a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC50 of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC50 of 132.8 μM). Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities .
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Cat. No.: HY-118545
CAS No.: 18109-80-3
Target:  

STAT

Research Areas:  

Inflammation/Immunology Cancer

Butamirate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate can be used for the study of glioblastoma .
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Cat. No.: HY-B1032
CAS No.: 17692-31-8
Synonyms: (±)-Dropropizine; UCB-196
Target:  

Histamine Receptor

Research Areas:  

Neurological Disease

Dropropizine ((±)-Dropropizine; UCB-196) is an orally effective, peripherally selective antitussive that inhibits the activity of peripheral receptors and afferent nerves in the respiratory tract. Dropropizine acts on the cough reflex pathway, does not pass the blood-brain barrier, and has no central nervous system side effects. Dropropizine mainly regulates the level of sensory neuropeptides and inhibits the afferent signal transmission of the cough reflex, thereby alleviating the symptoms of dry cough, and has both mild local anesthetic and antihistamine activity. Dropropizine is mainly used for symptomatic research on dry cough caused by respiratory diseases .
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Cat. No.: HY-18060
CAS No.: 639489-84-2
Synonyms: TC-5619
Target:  

nAChR

Research Areas:  

Neurological Disease

Bradanicline (TC-5619) is an orally active agonist of α7 nAChR with moderate blood-brain barrier penetration. Bradanicline exhibits high affinity and subtype selectivity for human α7 nAChR. Bradanicline possesses antitussive activity that depends on sustained receptor binding and activation. Bradanicline requires systemic administration to dose-dependently inhibit cough induced by citric acid, bradykinin and inhaled nicotine. Bradanicline is well tolerated in preclinical studies and is widely used in research related to chronic refractory cough .
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Cat. No.: HY-118545A
CAS No.: 18109-81-4
Purity:  99.88%
Target:  

STAT

Research Areas:  

Inflammation/Immunology Cancer

Butamirate citrate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate citrate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate citrate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate citrate can be used for the study of glioblastoma .
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Cat. No.: HY-N0413
CAS No.: 98243-57-3
Hupehenine is an orally active isosteroidal alkaloid that can be extracted from F. hupehensis. Hupehenine exhibits activities such as antitussive, expectorant, anticancer, and antiparasitic. In vitro, Hupehenine can also inhibit α-synuclein seeded fibril formation, making it applicable for the research of Parkinson's disease and other related disorders .
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Cat. No.: HY-N0808R
CAS No.: 76-22-2
Synonyms: (±)-Camphor (Standard)
Camphor (Standard) is the analytical standard of Camphor. This product is intended for research and analytical applications. Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities . Camphor is a TRPV3 agonist .
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Cat. No.: HY-B2090
CAS No.: 2167-85-3
Synonyms: SKF 70230A; SQ 15874; Pipazetate
Target:  

GABA Receptor

Research Areas:  

Others

Pipazethate (SKF 70230A), a pyridobenzothiazine derivative, is a potent GABA antagonist. Pipazethate has antitussive activity. Pipazethate can be used in research in cough supressant .
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Cat. No.: HY-118545AR
CAS No.: 18109-81-4
Research Areas:  

Inflammation/Immunology Cancer

Butamirate citrate (Standard) is the analytical standard of Butamirate citrate (HY-118545A). This product is intended for research and analytical applications. Butamirate citrate is an orally active antitussive agent that acts centrally through the receptors in the brainstem. Butamirate citrate also reduces the resistance in the airways by inhibiting bronchospasm and anti-inflammatory effect. Butamirate citrate inhibits glioblastoma (GBM) growth and STAT3 activity. Butamirate citrate can be used for the study of glioblastoma .
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Cat. No.: HY-W742300
CAS No.: 6056-11-7
Synonyms: SKF 70230A hydrochloride; SQ 15874 hydrochloride; Pipazetate hydrochloride
Target:  

GABA Receptor

Research Areas:  

Inflammation/Immunology

Pipazethate (SKF 70230A; SQ 15874) hydrochloride is a potent GABA antagonist. Pipazethate hydrochloride shows antitussive activity and can be used in research in cough suppressant .
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Cat. No.: HY-W015579
CAS No.: 464-48-2
(-)-Camphor is an enantiomer of Camphor (HY-N0808) and belongs to the class of bicyclic monoterpene ketones. Camphor ((±)-Camphor) is a topical anti-infective and antipruritic agent, and exhibits carminative effects when administered orally. However, Camphor is toxic upon ingestion. Camphor possesses antiviral, antitussive and anticancer activities. Camphor acts as a TRPV3 agonist .
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Cat. No.: HY-N3945R
CAS No.: 475-81-0
Synonyms: O,O-Dimethylisoboldine (Standard); S-(+)-Glaucine (Standard); NSC 34396 (Standard)
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .
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Cat. No.: HY-121644
CAS No.: 21363-18-8
Target:  

Opioid Receptor

Research Areas:  

Neurological Disease

Viminol is a centrally acting analgesic agent. Viminol also shows antitussive activity .
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Cat. No.: HY-N3197
CAS No.: 477953-07-4
Synonyms: (+)-Neostenine
Neostenine is a stenine-type Stemona alkaloid, with antitussive activity. Neostenine is also a substrate of P-glycoprotein with high absorptive permeability in Caco-2 monolayer model. Neostenine also shows oral activity for intestinal application .
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