98243-57-3
Chemical Structure
Hupehenine
- CAS No.: 98243-57-3
- Formula:C27H45NO2
- Molecular Weight:415.65
IUPAC Name: (3S,4aS,5R,6aS,6bS,8aR,9R,9aS,12S,15aS,15bR,16aS,16bR)-9,12,16b-trimethyltetracosahydrobenzo[4,5]indeno[1,2-h]pyrido[1,2-b]isoquinoline-3,5-diol
InChIKey: NEMWYOKGHGSVSC-MSSYMPDSSA-N
SMILES: O[C@H]1CC[C@@]2(C)[C@]([C@H](O)C[C@]3([H])[C@]2([H])C[C@]4([H])[C@@]3([H])CC[C@]5([H])[C@@]4([H])CN6[C@](CC[C@H](C)C6)([H])[C@@H]5C)([H])C1
Biological Activity: Hupehenine is an orally active isosteroidal alkaloid that can be extracted from F. hupehensis. Hupehenine exhibits activities such as antitussive, expectorant, anticancer, and antiparasitic. In vitro, Hupehenine can also inhibit α-synuclein seeded fibril formation, making it applicable for the research of Parkinson's disease and other related disorders[1][2][3][4].
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Hupehenine | 99.0% | Hupehenine is an orally active isosteroidal alkaloid that can be extracted from F. hupehensis. Hupehenine exhibits activities such as antitussive, expectorant, anticancer, and antiparasitic. In vitro, Hupehenine can also inhibit α-synuclein seeded fibril formation, making it applicable for the research of Parkinson's disease and other related disorders. | ||||||||||||||||||||
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Hupehenine (Standard) | ≥98% | Hupehenine (Standard) is the analytical standard of Hupehenine (HY-N0413). This product is intended for research and analytical applications. Hupehenine is an orally active isosteroidal alkaloid that can be extracted from F. hupehensis. Hupehenine exhibits activities such as antitussive, expectorant, anticancer, and antiparasitic. In vitro, Hupehenine can also inhibit α-synuclein seeded fibril formation, making it applicable for the research of Parkinson's disease and other related disorders. | ||||||||||||||||||||
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- [1]. Ghanem SS, et al. Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity. Molecules. 2021 Jun 19;26(12):3736. [Content Brief]
- [2]. Menpadi N, et al. Molecular Mechanisms of Cell Death in Leishmania donovani Induced by Selected Steroidal Alkaloids. J Basic Microbiol. 2025 Mar;65(3):e2400655. [Content Brief]
- [3]. Wen C, et al. Determination and validation of hupehenine in rat plasma by UPLC-MS/MS and its application to pharmacokinetic study. Biomed Chromatogr. 2015 Dec;29(12):1805-10. [Content Brief]
- [4]. Wu X, et al. Investigation of association of chemical profiles with the tracheobronchial relaxant activity of Chinese medicinal herb Beimu derived from various Fritillaria species. J Ethnopharmacol. 2018 Jan 10;210:39-46. [Content Brief]
Keywords
