66 Results for "

biotransformation

" in MedChemExpress (MCE) Product Catalog:
Products (66)

66 Results for "biotransformation" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-129217
CAS No.: 9068-31-9
Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase has wide occurrence in nature. Naringinase can be used in the biotransformation of steroids, antibiotics, and mainly on glycosides hydrolysis .
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Cat. No.: HY-W015590
CAS No.: 614-75-5
2-Hydroxyphenylacetic acid is a metabolite of Phenylalanine and Tyrosine, as well as a product of the biotransformation of Phenylacetonitrile by marine fungi. 2-Hydroxyphenylacetic acid acts as a potential biomarker for food. 2-Hydroxyphenylacetic acid slightly induces the expression of green fluorescent protein. 2-Hydroxyphenylacetic acid is used in the research of phenylketonuria and related hyperphenylalaninemia .
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Cat. No.: HY-135774
CAS No.: 152831-00-0
Purity:  99.86%
Research Areas:  

Cardiovascular Disease

6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an anti-angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting .
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Cat. No.: HY-P2816
CAS No.: 37278-89-0
Research Areas:  

Others

Xylanase is an enzyme targeting 1,4-β-D-xylan that randomly cleaves the β-1,4 backbone of xylan, a complex polysaccharide in plant cell walls. Xylanase finds applications in the food, feed and industrial sectors, including pulp and paper processing, baking, animal feed improvement, and biotransformation of waste .
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Cat. No.: HY-173351
CAS No.: 2901806-51-5
Target:  

SWI/SNF Complex

Research Areas:  

Cancer

G-6599 is a monovalent molecular glue-like degrader of SMARCA2/SMARCA4. G-6599 covalently binds to a specific cysteine residue of the E3 ligase FBXO22 in a biotransformation-independent manner, promotes the formation of a ternary complex with SMARCA2/A4, and achieves efficient and specific degradation of the two proteins via the ubiquitin-proteasome pathway. G-6599 is applicable to the research of androgen-dependent prostate cancer and mutant non-small cell lung cancer .
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Cat. No.: HY-P2800
CAS No.: 9001-18-7
Research Areas:  

Others

Diaphorase, Recombinant microorganisms can be obtained from anaerobic sludge organisms. Diaphorase catalyzes biotransformation of hexahydro-1,3, 5-trinitro-1,3, 5-triazine (RDX) by denitrification .
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Cat. No.: HY-106405
CAS No.: 274925-86-9
Purity:  99.89%
Synonyms: BIA 3-202
Target:  

COMT

Research Areas:  

Metabolic Disease

Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease .
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Cat. No.: HY-N7921
CAS No.: 1006683-97-1
Urolithin M6 is a polyhydroxy-rich metabolite with potential antioxidant activity. Urolithin M6 is produced by intestinal microbial metabolism and may act as an analog of tannic acid compounds. The production of Urolithin M6 in humans requires specific bacterial 3-dehydroxylase activity, which provides a new mechanism for its biotransformation. The metabolic profile of Urolithin M6 helps to stratify volunteers and further explore its potential role in health and disease .
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Cat. No.: HY-P2866A
CAS No.: 9012-33-3
Synonyms: NAG, Porcine kidney
Target:  

Glycosidase

Research Areas:  

Others

β-N-Acetylhexosaminidase, Porcine kidney is a glycosidase with transglycosylation activity, used to generate health-beneficial human milk oligosaccharides, and it effectively interacts with low molecular weight sugar alcohols (such as glycerol, erythritol, and xylitol). The enzyme exhibits optimal activity at pH 5 and 40 °C, and shows high thermal stability (up to 55°C) when bound to the cell wall. β-N-Acetylhexosaminidase holds promise for applications in the biotransformation of Chitin (HY-126389) and research in the food health sector .
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Cat. No.: HY-W102516
CAS No.: 1162-56-7
Synonyms: Δ6-Progesterone
6-Dehydroprogesterone (Δ6-Progesterone) is a steroid compound that can be found in Botryodiplodia theobromae. 6-Dehydroprogesterone is a metabolic product of Progesterone (HY-N0437) after a microbial dehydrogenation reaction. 6-Dehydroprogesterone can be used to study steroid metabolism pathways, microbial dehydrogenase activity, and the biotransformation of steroids .
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Cat. No.: HY-W153159
CAS No.: 13062-76-5
N-Methyltyramine hydrochloride is an orally active α2-adrenoreceptor antagonist with an IC50 value of 5.53 μM against rat targets. N-Methyltyramine hydrochloride blocks α2-adrenoreceptors, while inhibiting lipolysis, hyperactivity responses and small intestinal peristalsis in mice. N-Methyltyramine hydrochloride promotes gastrin release and pancreatic juice secretion, upregulates appetite, blood pressure, myocardial contraction frequency and contraction intensity, and increases renal blood flow, renal vascular resistance and mean peripheral arterial resistance. N-Methyltyramine hydrochloride relaxes mouse small intestinal smooth muscle and undergoes biotransformation in vivo to produce adrenaline. N-Methyltyramine hydrochloride can be used in studies related to gastrointestinal diseases .
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Cat. No.: HY-130465
CAS No.: 38753-76-3
Purity:  99.85%
Synonyms: Deacetylspironolactone; Mercaptospironolactone
Target:  

Drug Metabolite

Research Areas:  

Metabolic Disease

7α-Thiospironolactone is the transformation product of spironolactone (HY-B0561), which can be obtained by the metabolism of Thermomyces lanuginosus .
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Cat. No.: HY-N16639
CAS No.: 105330-51-6
(+)-Catechin-3’-O-β-D-glucoside is a mono glucoside derivative of (+)-catechin (HY-N0898) after biotransformation. (+)-Catechin-3’-O-β-D-glucoside is a potential antioxidant .
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Cat. No.: HY-N11677
CAS No.: 1035154-52-9
7-Hydroxy-TSU-68 is a derivative of TSU-68 (HY-10517). It is a metabolite of the biotransformation pathway of TSU-68 in human liver microsomes. The content represents the self-induced hydroxylation level of TSU-68 .
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Cat. No.: HY-N12167
CAS No.: 465-20-3
Category:  

Microorganisms Steroids

Target:  

Others

3-epi-Bufalin (compound 2a) is the microbial transformation product of bufadienolide .
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Cat. No.: HY-N7731A
CAS No.: 498-16-8
Synonyms: (R)-Lavandulol
(-)-Lavandulol is the isomer of (±)-Lavandulol (HY-N7731). (±)-Lavandulol is an irregular monoterpene alcohol. (±)-Lavandulol can be transformed by a fungal strain Rhizopus oryzae into corresponding oxygenated metabolite .
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Cat. No.: HY-N3994
CAS No.: 1097-51-4
Target:  

Drug Intermediate

Research Areas:  

Others

16α,17α-Epoxyprogesterone is an important steroid, serving as an intermediate for many hormonal drugs such as Hydrocortisone (HY-N0583) and Megestrol (HY-B1834). 16α,17α-Epoxyprogesterone can further biotransform into another significant intermediate, 11α-hydroxy-16α,17α-epoxyprogesterone, to manufacture additional compounds .
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Cat. No.: HY-119963A
CAS No.: 7299-41-4
Target:  

Bacterial

Research Areas:  

Infection Inflammation/Immunology

trans-β-Terpineol is a cyclic monoterpene alcohol present in Greek propolis and the essential oil of Peganum harmala seeds, with biological activities. trans-β-Terpineol serves as a substrate for biotransformation in tobacco suspension cells, where allylic hydroxylation occurs at specific sites. trans-β-Terpineol can be isolated from the leaves of Euryops arabicus. Terpineol (HY-N7851) exhibits antioxidant and antibacterial activities, and trans-β-terpineol is the bioactive compound responsible for the antibacterial effect in Euryops arabicus .
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Cat. No.: HY-W007401
CAS No.: 136030-00-7
(1R,2S)-1-Amino-2-indanol is a β-amino alcohol and pharmaceutical intermediate, serving as a structural component of the HIV protease inhibitor Indinavir (HY-B0689). (1R,2S)-1-Amino-2-indanol can be used in research related to organic synthesis .
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Cat. No.: HY-W153897
CAS No.: 370-98-9
N-Methyltyramine is an orally active α2-adrenoreceptor antagonist with an IC50 value of 5.53 μM against rat targets. N-Methyltyramine blocks α2-adrenoreceptors, while inhibiting lipolysis, hyperactivity responses and small intestinal peristalsis in mice. N-Methyltyramine promotes gastrin release and pancreatic juice secretion, upregulates appetite, blood pressure, myocardial contraction frequency and contraction intensity, and increases renal blood flow, renal vascular resistance and mean peripheral arterial resistance. N-Methyltyramine relaxes mouse small intestinal smooth muscle and undergoes biotransformation in vivo to produce adrenaline. N-Methyltyramine can be used in studies related to gastrointestinal diseases .
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