13-O-Desmethyl tacrolimus
13-O-Desmethyl tacrolimus (13-DMT; 13-O-Demethyl FK 506) is the major metabolite of Tacrolimus (HY-13756) formed via cytochrome P450 3A-mediated biotransformation. The ratio of 13-O-Desmethyl tacrolimus to Tacrolimus serves as a biomarker for myelotoxicity and hepatotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 139958-51-3
- Formula: C43H67NO12
- Molecular Weight:789.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
13O-Desmethyl tacrolimus (0.25-50 ng/mL) is accurately and precisely quantified in in vitro spiked rat kidney tissue homogenates via the validated LC-MS/MS assay, with stable performance through freeze-thaw cycling, 6 hours at room temperature, and 24 hours in the auto-sampler[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 139958-51-3
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Molecular Weight 789.99
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Formula C43H67NO12
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SMILES
CO[C@@H]1[C@@]2([H])O[C@@](C(C(N3[C@](CCCC3)([H])C(O[C@@H]([C@@H]([C@H](CC([C@@H](/C=C(C[C@@H](C1)C)\C)CC=C)=O)O)C)/C(C)=C/[C@H]4C[C@H]([C@@H](CC4)O)OC)=O)=O)=O)([C@@H](C[C@@H]2O)C)O
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Synonyms
13-DMT; 13-O-Demethyl FK 506
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
13-O-Desmethyl tacrolimus Related Classifications
HY-154916 Related Classifications
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