274925-86-9
Chemical Structure
Nebicapone
Synonym(s): BIA 3-202
- CAS No.: 274925-86-9
- Formula:C14H11NO5
- Molecular Weight:273.24
IUPAC Name: 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenylethan-1-one
InChIKey: MRFOLGFFTUGAEB-UHFFFAOYSA-N
SMILES: O=C(C1=CC([N+]([O-])=O)=C(O)C(O)=C1)CC2=CC=CC=C2
Biological Activity: Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease[1].
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Nebicapone | 99.89% | Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease. | ||||||||||||||||||||
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Nebicapone (Standard) | ≥98% | Nebicapone (Standard) is the analytical standard of Nebicapone. This product is intended for research and analytical applications. Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease. | ||||||||||||||||||||
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Similarity Score 0.74
HY-125339Ro 41-0960 -
Similarity Score 0.72
HY-17406RTolcapone (Standard) -
Similarity Score 0.71
HY-124817Col003 -
Similarity Score 0.70
HY-W018854R1-(4-(Benzyloxy)-3-nitrophenyl)-2-bromoethanone (Standard) -
Similarity Score 0.68
HY-W3513404-(Benzyloxy)-2-nitrophenol -
Similarity Score 0.65
![1-(3,4-Dihydroxyphenyl)-2-[methyl(phenylmethyl)amino]ethanone (Standard) Chemical Structure](//file.medchemexpress.com/product_pic/hy-w585975r.gif)
HY-W585975R1-(3,4-Dihydroxyphenyl)-2-[methyl(phenylmethyl)amino]ethanone (Standard) -
Similarity Score 0.65
HY-Z8728RAdrenaline impurity 3 (Standard) -
Similarity Score 0.64
HY-100642R3-O-Methyltolcapone (Standard) -
Similarity Score 0.64
HY-123365GV2-20 -
Explore the MedChemAI to find more analogs
![1-(3,4-Dihydroxyphenyl)-2-[methyl(phenylmethyl)amino]ethanone (Standard) Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w585975r.gif)
