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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
blue light
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "blue light" in MCE Product Catalog:
6
6 Publications Verification
Cat. No.: HY-D1571
CAS No.: 215868-45-4
3
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology
BMS-195614 (BMS 614) is an orally active neutral RARα-selective antagonist with a Ki of 2.5 nM. BMS-195614 restores the expression of Bcl2. BMS-195614 inhibits the transactivation of NF-κB, AP-1 and PPAR. BMS-195614 downregulates the expression of IL-6 and VEGF. BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis .
2
2 Cited Publications
Target:
Research Areas:
KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis .
1
1 Cited Publications
Cat. No.: HY-D0150
CAS No.: 107091-89-4
1
1 Cited Publications
Cat. No.: HY-D1416
CAS No.: 1287651-36-8
Synonyms: Coelenterazine 400a; Bisdeoxycoelenterazine
Synonyms: A2E TFA; N-retinylidene-N-retinylethanolamine TFA
Research Areas:
Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases .
Synonyms: Bluo-Gal
Target:
Research Areas:
5-Bromo-3-indolyl β-D-galactopyranoside (Bluo-Gal) is a chromogenic substrate for β-galactosidase. 5-Bromo-3-indolyl β-D-galactopyranoside is hydrolyzed by the enzyme to generate a 5-bromoindole intermediate, which is further oxidized to form an insoluble blue precipitate. 5-Bromo-3-indolyl β-D-galactopyranoside can specifically recognize bacterial β-galactosidases (such as the product of the Escherichia coli lacZ gene) and reacts at pH 7.4, making it suitable for light and electron microscopic observations. 5-Bromo-3-indolyl β-D-galactopyranoside can be used in histochemical detection of reporter gene expression in transgenic organisms, such as the localization analysis of β-galactosidase activity in mouse embryos or muscle tissues .
Cat. No.: HY-134928
CAS No.: 173449-96-2
Synonyms: A2E
Research Areas:
Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases .
Cat. No.: HY-D0026
CAS No.: 113721-87-2
Synonyms: 7-Amino-4-methyl-3-coumarinacetic acid N-succinimidyl ester
Cat. No.: HY-134928AS
Purity: ≥90.0%
Synonyms: A2E-d4 TFA
Cat. No.: HY-N11499
CAS No.: 132679-85-7
Target:
Cat. No.: HY-W997836
CAS No.: 74923-08-3
Synonyms: 4-AHP
Target:
Research Areas:
4-Amino-3-hydroxyphenylalanine dihydrochloride (4-AHP) is a photodegradation product of eumelanin. 4-Amino-3-hydroxyphenylalanine dihydrochloride can be used to investigate the development of cutaneous melanoma and age-related macular degeneration .
Cat. No.: HY-D0012A
CAS No.: 34722-90-2
Category:
Target:
Cat. No.: HY-118462A
CAS No.: 2320429-05-6
Synonyms: Coelenterazine 400a hydrochloride; Bisdeoxycoelenterazine hydrochloride
Target:
Research Areas:
Coelenteramine (Coelenterazine) 400a hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm . Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .
Cat. No.: HY-W087913
CAS No.: 596-01-0
Cat. No.: HY-178115
Research Areas:
MB-Buf is a conjugation of methylene blue (HY-14536) and bufalin (HY-N0877) . MB-Buf can targeting degrade GPX4 upon light activation. MB-Buf can induce cell apoptosis, ferroptosis, and ROS production. MB-Buf can be used for the research of cancer, such as breast cancer .
Cat. No.: HY-167632
CAS No.: 31272-50-1
Synonyms: (3R,3′S)-Zeaxanthin
Target:
Reactive Oxygen Species (ROS) Cytochrome P450 COX NO Synthase TNF Receptor UGT Glutathione S-transferase
Research Areas:
meso-Zeaxanthin ((3R,3′S)-Zeaxanthin) is an orally active xanthophyll carotenoid. meso-Zeaxanthin inhibits CYP1A1, CYP1A2, CYP2B1/2, COX-2, TNF-α and iNOS, and enhances the activities of Uridine diphosphate glucuronosyltransferase and Glutathione-S-transferase. meso-Zeaxanthin quenches oxygen free radicals. meso-Zeaxanthin filters short-wavelength blue light, alleviates oxidative damage and visual abnormalities. meso-Zeaxanthin reduces tumor incidence, prolongs tumor latency and survival rate of tumor-bearing mice, and inhibits paw edema. meso-Zeaxanthin can be used in research related to sarcoma and age-related macular degeneration .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
