70217-82-2
Chemical Structure
Coelenteramine 400a
Synonym(s): Coelenterazine 400a; Bisdeoxycoelenterazine
- CAS No.: 70217-82-2
- Formula:C26H21N3O
- Molecular Weight:391.46
IUPAC Name: 2,8-dibenzyl-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
InChIKey: MWOYPGFRXPPBOX-UHFFFAOYSA-N
SMILES: O=C1C(CC2=CC=CC=C2)=NC3=C(NC(C4=CC=CC=C4)=CN31)CC5=CC=CC=C5
Biological Activity: Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm[1][2]. Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET)[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Coelenteramine 400a | 99.70% | Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm. Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET). | ||||||||||||||||||||
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- [1]. Levi J, et, al. Bisdeoxycoelenterazine derivatives for improvement of bioluminescence resonance energy transfer assays. J Am Chem Soc. 2007 Oct 3;129(39):11900-1. [Content Brief]
- [2]. Bertrand L, et, al. The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS). J Recept Signal Transduct Res. Feb-Nov 2002;22(1-4):533-41. [Content Brief]
- [3]. Yuan M L, et al. Luminescence of coelenterazine derivatives with C-8 extended electronic conjugation[J]. Chinese Chemical Letters, 2016, 27(4): 550-554.
Keywords
