4,4'-Di-O-methylellagic acid
4,4'-Di-O-methylellagic acid (4,4'-DiOMEA; Nasutin C) can be isolated from the Australian termites. 4,4'-Di-O-methylellagic acid is blue-fluorescent under ultra-violet light. 4,4'-Di-O-methylellagic acid inhibits colon cancer cell proliferation via the wnt signal pathway.
For research use only. We do not sell to patients.
- CAS No.: 3374-77-4
- Formula: C16H10O8
- Molecular Weight:330.25
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Erythrocyte | IC50 |
1.1 mM
Compound: 9
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Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
Anticomplement activity in sheep erythrocytes assessed as concentration required for 50% hemolytic inhibition by classic pathway pretreated for 10 mins with guinea pig serum followed by erythrocyte addition measured after 30 mins by spectrophotometeric me
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[PMID: 29631958] |
| Erythrocyte | IC50 |
1.31 mM
Compound: 9
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Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
Anticomplement activity in rabbit erythrocytes assessed as concentration required for 50% hemolytic inhibition by alternative pathway pretreated for 10 mins with normal human serum followed by erythrocyte addition measured after 30 mins by spectrophotomet
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[PMID: 29631958] |
Chemical Information
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CAS No. 3374-77-4
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Molecular Weight 330.25
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Formula C16H10O8
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SMILES
O=C1C2=CC(OC)=C(O)C(O3)=C2C4=C(C3=O)C=C(OC)C(O)=C4O1
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Synonyms
4,4'-DiOMEA; Nasutin C
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Structure Classification
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Initial Source
Nasutitermes exitiosus
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. B. P. MOORE, et al. Coumarin-like Substances from Australian Termites. Nature. 1962.
[2]. Ana Ramírez de Molina, et al. The ellagic acid derivative 4,4'-di-O-methylellagic acid efficiently inhibits colon cancer cell growth through a mechanism involving WNT16. J Pharmacol Exp Ther. 2015, 353, 2. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4,4'-Di-O-methylellagic acid Related Classifications
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