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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
126 Results for "
bone morphogenetic protein
" in MedChemExpress (MCE) Product Catalog:
Products (126)
126 Results for "bone morphogenetic protein" in MCE Product Catalog:
93
93 Publications Verification
Synonyms: DM-3189
Target:
Research Areas:
LDN193189 (DM-3189) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .
93
93 Publications Verification
Synonyms: DM-3189 dihydrochloride
Target:
Research Areas:
LDN193189 (DM-3189) dihydrochloride is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .
93
93 Publications Verification
Synonyms: DM-3189 Tetrahydrochloride
Target:
Research Areas:
LDN193189 (DM-3189) Tetrahydrochloride is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva .
81
22
22 Cited Publications
Cat. No.: HY-P7007
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BMP4; MCOPS6; Prev. BMP2B; OFC11; bone morphogenetic protein 2B; BMP-4; bone morphogenetic protein 4 Preproprotein; ZYME; Alternative protein BMP4; DVR4; BMP2B1; bone morphogenetic protein 4; BMP-2B
21
21 Cited Publications
Cat. No.: HY-P7006
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: BMP2; SSFSC1; Prev. BMP2A; SSFSC; bone morphogenetic protein 2A; BMP-2; BMP2 protein; BDA2; bone morphogenetic protein 2; BMP-2A
Species:
Source:
8
8 Cited Publications
Target:
Research Areas:
BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM, activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. BMP signaling agonist sb4 activates BMP4 target genes (inhibitors of DNA binding,?Id1?and?Id3) canonical BMP signaling .
5
4
4 Cited Publications
Target:
Research Areas:
K02288 is a potent bone morphogenetic protein (BMP) type I receptor inhibitor with IC50s of 1.8, 1.1, 6.4 nM for ALK1, ALK2 and ALK6, respectively. K02288 shows slightly weaker inhibition against ALK3 and ALK6 with IC50s of of 5-34 nM.
4
4 Cited Publications
Cat. No.: HY-P74379
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BMP4; MCOPS6; Prev. BMP2B; OFC11; bone morphogenetic protein 2B; BMP-4; bone morphogenetic protein 4 Preproprotein; ZYME; Alternative protein BMP4; DVR4; BMP2B1; bone morphogenetic protein 4; BMP-2B
3
3 Cited Publications
Cat. No.: HY-N0316
CAS No.: 55481-88-4
3
3 Cited Publications
Target:
Research Areas:
SJ000291942 is an activator of the canonical bone morphogenetic proteins (BMP) signaling pathway. BMPs are members of the transforming growth factor beta (TGFβ) family of secreted signaling molecules.
3
3 Cited Publications
Cat. No.: HY-P77945
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: GDF15; Placental bone morphogenetic protein; Growth Differentiation Factor 15; Macrophage Inhibitory Cytokine 1; MIC-1; NSAID-Activated Gene 1 protein; NAG-1; NSAID-Regulated Gene 1 protein; PTGFB; Placental TGF-Beta; PLAB; GDF-15; MIC1; NRG-1; PDF; NSAID
2
2 Cited Publications
Cat. No.: HY-16712
CAS No.: 1627503-67-6
Target:
Research Areas:
LDN-214117 is an orally active ALK2 inhibitor with well-tolerated and good brain penetration. LDN-214117 has a high selectivity and low cytotoxicity for ALK2 with an IC50 value of 24 nM. LDN-214117 also is a specific bone morphogenetic proteins (BMPs) signaling inhibitor and has relatively selective inhibition for BMP6 with an IC50 value of 100 nM. LDN-214117 can be used for the research of fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine glioma (DIPG) .
2
2 Cited Publications
Target:
Research Areas:
LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC50: 1.3 nM). LDN-212854 also inhibits ALK1 (IC50: 2.40 nM). LDN-212854 can be used in the research of fibrodysplasia ossificans progressive and cancers, such as hepatocellular carcinoma (HCC) .
2
2
2
2 Cited Publications
Cat. No.: HY-P72633
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GDF5; LAP-4; Growth Differentiation Factor 5; Cartilage-Derived morphogenetic protein 1; CDMP1; GDF5 protein; BMP14; DUPANS; Growth/Differentiation Factor 5; CDMP-1; bone morphogenetic protein 14; BDA1C; Cartilage-Derived morphogenetic protein-1; SYM1B; Lipopolysaccharide-Associated protein 4; SYNS2; LPS-Associated protein 4; GDF-5; Radotermin; LAP4; BMP-14; OS5
2
2 Cited Publications
Cat. No.: HY-P700530
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GDF2; Growth/Differentiation Factor 2; Growth Differentiation Factor 2; bone morphogenetic protein 9; BMP-9; GDF-2; BMP9; HHT5
Species:
Source:
2
Target:
Research Areas:
Sitaxsentan (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
