LDN193189 hydrochloride
Based on 81 publication(s) in Google Scholar
LDN193189 (DM-3189) hydrochloride is a potent selective BMP type I receptor (BMP I) inhibitor. LDN193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva.
For research use only. We do not sell to patients.
- Purity: 98.62%
- CAS No.: 1062368-62-0
- Formula: C25H23ClN6
- Molecular Weight:442.94
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) LDN193189 hydrochloride
More- Cancer Cell. 2026 May 21:S1535-6108(26)00220-5.
- Eur Respir J. 2022 Jul 7;60(1):2100327. [Abstract]
- Mol Cell. 2026 Jun 12:S1097-2765(26)00344-8. [Abstract]
- Mol Cell. 2022 Aug 4;82(15):2779-2796.e10. [Abstract]
- Nucleic Acids Res. 2025 Oct 14;53(19):gkaf995. [Abstract]
- Adv Sci (Weinh). 2025 Nov 7:e12325. [Abstract]
- Adv Sci (Weinh). 2025 Aug;12(32):e02774. [Abstract]
- Adv Sci (Weinh). 2024 Mar;11(10):e2308072. [Abstract]
- Biomaterials. 2020 May:240:119849. [Abstract]
- Cell Commun Signal. 2024 May 30;22(1):300. [Abstract]
- J Hazard Mater. 2024 Mar 5:465:133028. [Abstract]
- Free Radic Biol Med. 2024 Dec 9:227:296-311. [Abstract]
- Stem Cell Res Ther. 2025 May 13;16(1):239. [Abstract]
- Stem Cell Res Ther. 2024 Dec 18;15(1):478. [Abstract]
- Stem Cell Res Ther. 2023 Jan 5;14(1):1. [Abstract]
- Stem Cell Res Ther. 2022 Sep 2;13(1):436. [Abstract]
- Stem Cell Res Ther. 2022 Aug 19;13(1):424. [Abstract]
- Cell Rep. 2023 Dec 5;42(12):113541. [Abstract]
- Neurosci Bull. 2026 Apr 11. [Abstract]
- Antioxid Redox Signal. 2025 Nov;43(13-15):709-726. [Abstract]
- Biomater Adv. 2026 Jun 16:188:215018. [Abstract]
- Cells. 2026 Jun 17;15(12):1101. [Abstract]
- Neurobiol Dis. 2026 Jun 15:224:107397. [Abstract]
- EMBO Rep. 2023 Sep 6;24(9):e56454. [Abstract]
- Cancer Metab. 2023 Jul 13;11(1):9. [Abstract]
- Cell Rep Methods. 2026 Apr 20;6(4):101372. [Abstract]
- Cell Rep Methods. 2024 May 20;4(5):100777. [Abstract]
- Mar Drugs. 2022 Nov 14;20(11):715. [Abstract]
- Cell Regen. 2025 May 16;14(1):18. [Abstract]
- Int J Mol Sci. 2024 Apr 9;25(8):4138. [Abstract]
- Int J Mol Sci. 2022 Nov 27;23(23):14831. [Abstract]
- Animal Research and One Health. 2026 Mar 19.
- Front Cell Dev Biol. 2021 May 13:9:673231. [Abstract]
- Sci Rep. 2022 Mar 25;12(1):5221. [Abstract]
- Sci Rep. 2022 Mar 18;12(1):4740. [Abstract]
- Transl Oncol. 2020 Feb;13(2):125-134. [Abstract]
- Stem Cells. 2023 Jun 15;41(6):603-616. [Abstract]
- Oncol Rep. 2026 Apr;55(4):62. [Abstract]
- Cell Signal. 2025 Dec:136:112116. [Abstract]
- iScience. 2024 Feb 5;27(3):109111. [Abstract]
- iScience. 2022 Dec 26;26(1):105898. [Abstract]
- Biomedicines. 2022 Apr 18;10(4):928. [Abstract]
- iScience. 2019 Sep 27:19:1248-1259. [Abstract]
- Front Mol Biosci. 2021 Apr 26:8:663987. [Abstract]
- FASEB J. 2026 Apr 15;40(7):e71420. [Abstract]
- J Biomed Mater Res A. 2025 Oct;113(10):e38001. [Abstract]
- Cell Transplant. 2024 Jan-Dec:33:9636897241288932. [Abstract]
- Stem Cells Int. 2022 Dec 22:2022:1278921. [Abstract]
- Stem Cells Int. 2022 Apr 28;2022:1560943. [Abstract]
- Pigment Cell Melanoma Res. 2024 Jan;37(1):21-35. [Abstract]
- Neuroscience. 2026 Jun 6:610:122-135. [Abstract]
- Cardiovasc Toxicol. 2019 Jun;19(3):264-275. [Abstract]
- Biochim Biophys Acta Gen Subj. 2022 Jan;1866(1):130046. [Abstract]
- Int J Stem Cells. 2023 May 30;16(2):156-167. [Abstract]
- J Oral Biosci. 2026 Feb;68(1):100735. [Abstract]
- Exp Ther Med. 2019 Apr;17(4):2648-2656. [Abstract]
- Int J Ophthalmol. 2022 May 18;15(5):711-720. [Abstract]
- J Recept Signal Transduct Res. 2017 Oct;37(5):515-521. [Abstract]
- Dev Growth Differ. 2025 Apr;67(3):149-164. [Abstract]
- STAR Protoc. 2024 Nov 27;5(4):103466. [Abstract]
- bioRxiv. 2026 Apr 24.
- bioRxiv. 2026 Feb 16:2026.02.13.705790. [Abstract]
- bioRxiv. 2025 Oct 11.
- Elife. 2025 Aug 28:14:RP104774. [Abstract]
- bioRxiv. 2025 Aug 8:2025.08.08.669417. [Abstract]
- bioRxiv. 2025 April 14.
- bioRxiv. 2025 February 21.
- bioRxiv. 2025 March 15.
- bioRxiv. 2024 November 15.
- bioRxiv. 2024 November 28.
- Res Sq. 2024 Nov 14.
- bioRxiv. 2024 Nov 4:2024.10.08.617155. [Abstract]
- Patent. US20240247230A1.
- bioRxiv. 2024 Aug 6:2024.08.05.606734. [Abstract]
- bioRxiv. 2024 Jul 11:2024.07.08.602611. [Abstract]
- bioRxiv. 2024 Mar 13.
- bioRxiv. 2024 Mar 25:2024.03.21.585753. [Abstract]
- Research Square Preprint. 2023 May 17.
- Patent. US20210346386A1.
- Research Square Preprint. 2021 Sep.
- Oxid Med Cell Longev. 2020 Jun 8:2020:4175613. [Abstract]
Customer Validation & Images
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Cell Migration/Invasion Assay
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IHC
Biological Activity
IC50: 5 nM (ALK2), 30 nM (ALK3)[1]
LDN193189 hydrochloride efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively[1].
LDN193189 hydrochloride has weake effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7 with IC50 values of ≥ 500 nM[1].
LDN193189 hydrochloride binds ActRIIA with Kd value of 14 nM[2].
LDN193189 hydrochloride (0.5 μM; 30 min) targets GDF8 induced Smad2/3 signaling and repression of myogenic transcription factors[2].
LDN193189 hydrochloride (0.05, 0.5, 5 μM) efficiently inhibits GDF8 induced Smad3/4 reporter gene activity[2].
LDN193189 hydrochloride (0-5 μM) rescues myogenesis in myoblasts treated with GDF8[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
LDN193189 (i.p.; 3 mg/kg; single) hydrochloride shows a reduction in ectopic ossification and functional impairment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1062368-62-0
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Appearance Solid
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Molecular Weight 442.94
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Formula C25H23ClN6
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Color Yellow to orange
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SMILES
[H]Cl.C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=CC=NC6=CC=CC=C16
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Synonyms
DM-3189 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (81)
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Journal Impact Factor
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Most Recent
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Eur Respir J
Single-cell RNA sequencing reveals that BMPR2 mutation regulates right ventricular function via ID genes. [Abstract]2022 Jul 7;60(1):2100327. PMID: 34857612 -
Mol Cell
Distinct associations of pioneer factor Ascl1-E12a with nucleosomes drive changes in cell fate. [Abstract]2026 Jun 12:S1097-2765(26)00344-8. PMID: 42285106 -
Mol Cell
AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay. [Abstract]2022 Aug 4;82(15):2779-2796.e10. PMID: 35675814 -
Nucleic Acids Res
mRNA turnover dynamics are affected by cell differentiation and loss of the cytosine methyltransferase Nsun2. [Abstract]2025 Oct 14;53(19):gkaf995. PMID: 41099711 -
Adv Sci (Weinh)
Quantifying the Single-Cell Morphological Landscape of Cellular Transdifferentiation through Force Field Reconstruction. [Abstract]2025 Nov 7:e12325. PMID: 41203584 -
Adv Sci (Weinh)
Single-Cell RNA Sequencing Identifies MMP11+ Cancer-Associated Fibroblasts as Drivers of Angiogenesis and Bladder Cancer Progression. [Abstract]2025 Aug;12(32):e02774. PMID: 40552583 -
Adv Sci (Weinh)
2024 Mar;11(10):e2308072. PMID: 38239021 -
Biomaterials
2020 May:240:119849. PMID: 32087458 -
Cell Commun Signal
Low concentrations of saracatinib promote definitive endoderm differentiation through inhibition of FAK-YAP signaling axis. [Abstract]2024 May 30;22(1):300. PMID: 38816763 -
J Hazard Mater
Typical neonicotinoids and organophosphate esters, but not their metabolites, adversely impact early human development by activating BMP4 signaling. [Abstract]2024 Mar 5:465:133028. PMID: 38006857 -
Free Radic Biol Med
2024 Dec 9:227:296-311. PMID: 39653130 -
Stem Cell Res Ther
Mesenchymal stem cells derived from hPSC via neural crest attenuate chemotherapy-induced premature ovarian insufficiency by ameliorating apoptosis and oxidative stress in granulosa cells. [Abstract]2025 May 13;16(1):239. PMID: 40361250 -
Stem Cell Res Ther
Transcriptomic and proteomic sequencing unveils the role of vitamin D and metabolic flux shifts in the induction of human hepatic organoids. [Abstract]2024 Dec 18;15(1):478. PMID: 39696644 -
Stem Cell Res Ther
CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs. [Abstract]2023 Jan 5;14(1):1. PMID: 36600289 -
Stem Cell Res Ther
Stable expression of a truncated TLX variant drives differentiation of induced pluripotent stem cells into self-renewing neural stem cells for production of extracellular vesicles. [Abstract]2022 Sep 2;13(1):436. PMID: 36056423 -
Stem Cell Res Ther
Aucubin promotes bone-fracture healing via the dual effects of anti-oxidative damage and enhancing osteoblastogenesis of hBM-MSCs. [Abstract]2022 Aug 19;13(1):424. PMID: 35986345
LDN193189 hydrochloride purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2022 Aug 19;13(1):424. [Abstract]
Phospho-Smad1/5/9, COL1A1 and RUNX2 were quantified in hBM-MSCs after 3 days of treatment with LDN193189 (100 nM; 3 days) by western blot analysis and normalized to GAPDH and tSmad1.
LDN193189 hydrochloride purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2022 Aug 19;13(1):424. [Abstract]
LDN193189 (100 nM; 3 days). Representative images and quantification of immunofluorescence staining of COL1A1. Scale bars, 100 μm.
LDN193189 hydrochloride purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2022 Aug 19;13(1):424. [Abstract]
LDN193189 (100 nM; 3 days). Representative images of ARS.
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Cell Rep
ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors. [Abstract]2023 Dec 5;42(12):113541. PMID: 38060444 -
Neurosci Bull
Engineered Alzheimer Organoids Validate the Link Between Intracellular and Soluble p-Tau Biomarkers and Highlight the Contribution of Astrocytic Tau. [Abstract]2026 Apr 11. PMID: 41964788 -
Antioxid Redox Signal
Remifentanil Mitigates Hepatic Ischemia/Reperfusion-Induced D1-Medium Spiny Neurons Damage via Fibroblast Growth Factor 18 Upregulation. [Abstract]2025 Nov;43(13-15):709-726. PMID: 40810178 -
Biomater Adv
A supramolecular MgTA@MnO₂ nanozyme platform supports human spinal cord organoid structural integration and locomotor recovery via microenvironmental reprogramming. [Abstract]2026 Jun 16:188:215018. PMID: 42309040 -
Cells
Compensatory Intercellular Mitochondrial Transfer Improves Bioenergetics in P301L Tau-Affected Neuronal Cells. [Abstract]2026 Jun 17;15(12):1101. PMID: 42346128 -
Neurobiol Dis
Neuronal ACVR1-mediated H3K18 lactylation drives NLRP3 pyroptosis to sustain neuropathic pain via metabolic-epigenetic coupling. [Abstract]2026 Jun 15:224:107397. PMID: 41991084 -
EMBO Rep
Terminal differentiation of villus tip enterocytes is governed by distinct Tgfβ superfamily members. [Abstract]2023 Sep 6;24(9):e56454. PMID: 37493498 -
Cancer Metab
BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells. [Abstract]2023 Jul 13;11(1):9. PMID: 37443106 -
Cell Rep Methods
Wnt activation and dual SMAD inhibition for induction and maintenance of hindbrain-like neural stem cell from hiPSCs. [Abstract]2026 Apr 20;6(4):101372. PMID: 41916305 -
Cell Rep Methods
2024 May 20;4(5):100777. PMID: 38744289 -
Mar Drugs
2022 Nov 14;20(11):715. PMID: 36421992 -
Cell Regen
The critical role of BMP signaling in gastric epithelial cell differentiation revealed by organoids. [Abstract]2025 May 16;14(1):18. PMID: 40377813 -
Int J Mol Sci
Small Molecules Promote the Rapid Generation of Dental Epithelial Cells from Human-Induced Pluripotent Stem Cells. [Abstract]2024 Apr 9;25(8):4138. PMID: 38673725 -
Int J Mol Sci
BMP/Smad Pathway Is Involved in Lithium Carbonate-Induced Neural-Tube Defects in Mice and Neural Stem Cells. [Abstract]2022 Nov 27;23(23):14831. PMID: 36499158 -
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Front Cell Dev Biol
miR-212/132-Enriched Extracellular Vesicles Promote Differentiation of Induced Pluripotent Stem Cells Into Pancreatic Beta Cells. [Abstract]2021 May 13:9:673231. PMID: 34055806 -
Sci Rep
2022 Mar 25;12(1):5221. PMID: 35338209 -
Sci Rep
Characterization and reduction of non-endocrine cells accompanying islet-like endocrine cells differentiated from human iPSC. [Abstract]2022 Mar 18;12(1):4740. PMID: 35304548 -
Transl Oncol
Autocrine BMP4 Signaling Enhances Tumor Aggressiveness via Promoting Wnt/β-Catenin Signaling in IDH1-mutant Gliomas. [Abstract]2020 Feb;13(2):125-134. PMID: 31865175 -
Stem Cells
Neuroprotective effects of genome-edited human iPS cell-derived neural stem/progenitor cells on traumatic brain injury. [Abstract]2023 Jun 15;41(6):603-616. PMID: 37029780 -
Oncol Rep
POSTN+ fibroblast‑secreted small extracellular vesicles drive macrophage M2 polarization through BMP4/BMPR2/Smad signaling. [Abstract]2026 Apr;55(4):62. PMID: 41645751 -
Cell Signal
Inhibition of ferroptosis rescues BMP osteogenic differentiation impaired by iron overload in the osteoporotic microenvironment. [Abstract]2025 Dec:136:112116. PMID: 40930476 -
iScience
Modeling the precise interaction of glioblastoma with human brain region-specific organoids. [Abstract]2024 Feb 5;27(3):109111. PMID: 38390494 -
iScience
Generation of dorsoventral human spinal cord organoids via functionalizing composite scaffold for drug testing. [Abstract]2022 Dec 26;26(1):105898. PMID: 36647382 -
Biomedicines
Generation of a Pure Culture of Neuron-like Cells with a Glutamatergic Phenotype from Mouse Astrocytes. [Abstract]2022 Apr 18;10(4):928. PMID: 35453678 -
iScience
2019 Sep 27:19:1248-1259. PMID: 31353167 -
Front Mol Biosci
Macrophages Inhibit Ciliary Protein Levels by Secreting BMP-2 Leading to Airway Epithelial Remodeling Under Cigarette Smoke Exposure. [Abstract]2021 Apr 26:8:663987. PMID: 33981724 -
FASEB J
Transcription Factor GATA3 Ameliorates Sepsis-Associated Acute Respiratory Distress Syndrome by Activating Smad1/5-YAP Pathway via BMP9. [Abstract]2026 Apr 15;40(7):e71420. PMID: 41920072 -
J Biomed Mater Res A
GelMA Hydrogel Encapsulating iPSC-Derived Human Spinal Cord Organoids Enhances Neural Regeneration and Restores Motor Function in Rat Spinal Cord Injury. [Abstract]2025 Oct;113(10):e38001. PMID: 41051068 -
Cell Transplant
Xenogenic Engraftment of Human-Induced Pluripotent Stem Cell-Derived Pancreatic Islet Cells in an Immunosuppressive Diabetic Göttingen Mini-Pig Model. [Abstract]2024 Jan-Dec:33:9636897241288932. PMID: 39401129 -
Stem Cells Int
2022 Dec 22:2022:1278921. PMID: 36591373 -
Stem Cells Int
Palovarotene Can Attenuate Heterotopic Ossification Induced by Tendon Stem Cells by Downregulating the Synergistic Effects of Smad and NF- κ B Signaling Pathway following Stimulation of the Inflammatory Microenvironment. [Abstract]2022 Apr 28;2022:1560943. PMID: 35530413 -
Pigment Cell Melanoma Res
Modeling of pigmentation disorders associated with MITF mutation in Waardenburg syndrome revealed an impaired melanogenesis pathway in iPS-derived melanocytes. [Abstract]2024 Jan;37(1):21-35. PMID: 37559350 -
Neuroscience
Trichostatin A-primed spinal cord organoids alleviate oxidative stress and improve recovery after spinal cord injury involving the NRF2/HO-1 signaling pathway. [Abstract]2026 Jun 6:610:122-135. PMID: 42250855 -
Cardiovasc Toxicol
MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte. [Abstract]2019 Jun;19(3):264-275. PMID: 30535663
LDN193189 hydrochloride purchased from MedChemExpress. Usage Cited in: Cardiovasc Toxicol. 2019 Jun;19(3):264-275. [Abstract]
H9c2 cells are treated as following: control, DOX, DOX + rhBMP (Bmpr1a agonist) and DOX + LDN193189 (Bmpr1a inhibitor). Cells with red fluorescence indicate favorable MMP while green fluorescence indicates damage.
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Biochim Biophys Acta Gen Subj
Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERα levels. [Abstract]2022 Jan;1866(1):130046. PMID: 34743989 -
Int J Stem Cells
Strategic Application of Epigenetic Regulators for Efficient Neuronal Reprogramming of Human Fibroblasts. [Abstract]2023 May 30;16(2):156-167. PMID: 36823979 -
J Oral Biosci
Bone morphogenetic protein-2 and transforming growth factor-β1 regulate cell proliferation and ectopic claudin-4 expression in parotid acinar cells. [Abstract]2026 Feb;68(1):100735. PMID: 41714034 -
Exp Ther Med
Bone morphogenetic protein 4 promotes the differentiation of Tbx18-positive epicardial progenitor cells to pacemaker-like cells. [Abstract]2019 Apr;17(4):2648-2656. PMID: 30906456 -
Int J Ophthalmol
Chordin-like 2 influences the differentiation fate of retinal pigment epithelium cells by dynamically regulating BMP pathway. [Abstract]2022 May 18;15(5):711-720. PMID: 35601169 -
J Recept Signal Transduct Res
Functional expression of BMP7 receptors in oral epithelial cells. Interleukin-17F production in response to BMP7. [Abstract]2017 Oct;37(5):515-521. PMID: 28812969 -
Dev Growth Differ
Transforming growth factor-β-mediated regulation of atoh1-expressing neural progenitors is involved in the generation of cerebellar granule cells in larval and adult zebrafish. [Abstract]2025 Apr;67(3):149-164. PMID: 40012512 -
STAR Protoc
2024 Nov 27;5(4):103466. PMID: 39607824 -
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bioRxiv
Neuronal Cell-Cycle Re-entry Defines Divergent Outcomes Through Replication-Dependent DNA Damage in ALS. [Abstract]2026 Feb 16:2026.02.13.705790. PMID: 41756973 -
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Elife
Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes. [Abstract]2025 Aug 28:14:RP104774. PMID: 40874922 -
bioRxiv
2025 Aug 8:2025.08.08.669417. PMID: 40855884 -
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bioRxiv
2024 Nov 4:2024.10.08.617155. PMID: 39415993 -
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bioRxiv
Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection. [Abstract]2024 Aug 6:2024.08.05.606734. PMID: 39149298 -
bioRxiv
2024 Jul 11:2024.07.08.602611. PMID: 39026750 -
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bioRxiv
2024 Mar 25:2024.03.21.585753. PMID: 38585971 -
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Oxid Med Cell Longev
The Attenuating Effect of the Intraovarian Bone Morphogenetic Protein 4 on Age-Related Endoplasmic Reticulum Stress in Chicken Follicular Cells. [Abstract]2020 Jun 8:2020:4175613. PMID: 32587659
LDN193189 hydrochloride purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jun 8:2020:4175613. [Abstract]
Western blot and grey analysis of CYP11a1, CYP19a1, BCL2, CALR, CHOP, caspase3, caspase12, PERK, and GRP78. qRT-PCR analyzed ATF4, caspase3, and GRP78 mRNAs. The relieving function of BMP4 on ER stress is diminished after blockade of BMP receptor I (BMPRI) with DM-3189.
Solvent & Solubility
H2O : 25 mg/mL (56.44 mM; Need ultrasonic)
DMSO : 12.5 mg/mL (28.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Yu PB, et al. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med, 2008, 14(12), 1363-1369. [Content Brief]
[2]. Daniel Horbelt, et al. Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation. J Biol Chem. 2015 Feb 6;290(6):3390-404. [Content Brief]
[3]. Julien Vollaire, et al. The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice. Front Pharmacol. 2019 Jun 19;10:667. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.2576 mL | 11.2882 mL | 22.5764 mL | 56.4411 mL |
| 5 mM | 0.4515 mL | 2.2576 mL | 4.5153 mL | 11.2882 mL | |
| 10 mM | 0.2258 mL | 1.1288 mL | 2.2576 mL | 5.6441 mL | |
| 15 mM | 0.1505 mL | 0.7525 mL | 1.5051 mL | 3.7627 mL | |
| 20 mM | 0.1129 mL | 0.5644 mL | 1.1288 mL | 2.8221 mL | |
| 25 mM | 0.0903 mL | 0.4515 mL | 0.9031 mL | 2.2576 mL | |
| H2O | 30 mM | 0.0753 mL | 0.3763 mL | 0.7525 mL | 1.8814 mL |
| 40 mM | 0.0564 mL | 0.2822 mL | 0.5644 mL | 1.4110 mL | |
| 50 mM | 0.0452 mL | 0.2258 mL | 0.4515 mL | 1.1288 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
LDN193189 hydrochloride Related Classifications
HY-12071C Related Classifications
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