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Pathways Recommended:	Immunology/Inflammation

Results for "

colonic inflammation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Bacterial (2) c-Fms (2) CaMK (1) Drug Metabolite (1) Endogenous Metabolite (2) Glutathione Peroxidase (1) Glutathione S-transferase (1) HIV (1) iGluR (1) Interleukin Related (2) JAK (1) Leukotriene Receptor (2) mAChR (1) NF-κB (2) NOD-like Receptor (NLR) (1) P-glycoprotein (1) p38 MAPK (2) Parasite (1) Phosphatase (1) Reactive Oxygen Species (ROS) (1) SOD (1) STAT (1) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (4) Inflammation/Immunology (15) Metabolic Disease (2) Neurological Disease (4)

By Targets:

Apoptosis (2)

Bacterial (2)

c-Fms (2)

CaMK (1)

Drug Metabolite (1)

Endogenous Metabolite (2)

Glutathione Peroxidase (1)

Glutathione S-transferase (1)

HIV (1)

iGluR (1)

Interleukin Related (2)

JAK (1)

Leukotriene Receptor (2)

mAChR (1)

NF-κB (2)

NOD-like Receptor (NLR) (1)

P-glycoprotein (1)

p38 MAPK (2)

Parasite (1)

Phosphatase (1)

Reactive Oxygen Species (ROS) (1)

SOD (1)

STAT (1)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (4)

Cardiovascular Disease (2)

Infection (4)

Inflammation/Immunology (15)

Metabolic Disease (2)

Neurological Disease (4)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2818

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial	Infection Inflammation/Immunology
Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation .

HY-P990125

Anti-Mouse CSF1R/CD115 Antibody (AFS98)	c-Fms	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Anti-Mouse (CSF1R/CD115) Antibody (AFS98) is an anti-mouse CSF1R IgG2a antibody inhibitor derived from rats. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) inhibits M-CSF-dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) can be used for the researches of inflammation, metabolic disease, cardiovascular disease and neurological disease, such as such as stroke, diabetes and arthritis .

HY-P99440

Anumigilimab CSL-324	c-Fms JAK STAT	Inflammation/Immunology
Anumigilimab (CSL-324) is an human IgG4 mAb against human *granulocyte colony-stimulating factor (G-CSF) receptor. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation* .

HY-N1916

Coniferyl ferulate 1 Publications Verification	Glutathione S-transferase P-glycoprotein Apoptosis iGluR CaMK p38 MAPK Reactive Oxygen Species (ROS) Bacterial	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Coniferyl ferulate is an orally active phenolic acid compound. Coniferyl ferulate is a potent inhibitor of glutathione S-transferase (GST) (IC₅₀ = 0.3 μM), which downregulates P-gp expression, induces apoptosis in B-MD-C1 (ADR+/+) cells, and reverses multidrug resistance. Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice. Coniferyl ferulate can alleviate the toxicity of xylene to hematopoietic stem and progenitor cells by targeting Mgst2. Coniferyl ferulate exhibits antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus .

HY-114988

PGE-M tetranor-PGEM	Drug Metabolite	Metabolic Disease Inflammation/Immunology Cancer
PGE-M (tetranor-PGEM) is a metabolite of Prostaglandin E₂ (HY-101952) and also an inflammatory biomarker. Urinary PGE-M is a potential biomarker for detecting advanced colorectal tumors. PGE-M can be used in studies related to colorectal cancer, obesity, aging and breast cancer .

HY-119684

Maresin 2	NOD-like Receptor (NLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Maresin 2 is an anti-inflammatory and pro-resolving mediator. Maresin 2 drives intestinal epithelial cell migration by activating the focal cell-matrix adhesion signaling pathway in primary human intestinal epithelial cells, thereby promoting mucosal wound repair. Maresin 2 alleviates nociceptive and anxiety-like behaviors in rats with type 1 diabetes by inhibiting IL-1β in the spinal cord and prefrontal cortex. Maresin 2 attenuates allergic airway inflammation in mice by inhibiting the activation of the NLRP3 inflammasome, Th2-type immune responses, and oxidative stress. Maresin 2 inhibits inflammatory and neuropathic trigeminal neuralgia and reduces neuronal activation in the trigeminal ganglion. Maresin 2 promotes inflammation resolution and mucosal repair after DSS-induced colitis or biopsy-induced colonic mucosal injury .

HY-107648

McN-A-343 2 Publications Verification	mAChR	Neurological Disease Inflammation/Immunology
McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 produces a significant inhibitory effect on Muscarine (HY-121404)-evoked catecholamine secretion from the isolated perfused rat adrenal gland. McN-A-343 is involved in the regulation of neuronal firing and activates enteroendocrine L cells to release glucagon-like peptide 1 (GLP-1) and modulates the secretion of α-melanocyte stimulating hormone (α-MSH) from the pituitary gland in the central nervous system. McN-A-343 reduces colonic inflammation and oxidative stress in Acetic acid (HY-Y0319)-induced ulcerative colitis (UC) mice. McN-A-343 can be used for the study of ulcerative colitis .

HY-177116

GPR15 antagonist-1	HIV	Infection Inflammation/Immunology
GPR15 antagonist-1 (Compound 5) is a GPR15 antagonist. G protein-coupled receptor 15 (GPR15) is an extensively studied GPCRs involving HIV infection, colonic inflammation, and smoking-related diseases .

HY-W265314

Arvelexin	NF-κB Interleukin Related	Inflammation/Immunology
Arvelexin is a biologically active compound. Arvelexin can be found in Brassica rapa L. (Brassicaceae). Arvelexin inhibits NF-κB activation and the expressions of IL-8. Arvelexin inhibits colonic inflammation .

HY-112740

SC-53228	Leukotriene Receptor	Inflammation/Immunology
SC-53228 is an orally active human leukotriene B4 receptor (LTB4 receptor) antagonist. SC-53228 exerts its anti-inflammatory effect by specifically blocking the LTB4 receptor and inhibiting neutrophil infiltration. SC-53228 has demonstrated significant efficacy and good safety in various inflammatory models. SC-53228 can be used for a variety of inflammatory diseases, such as psoriasis and ulcerative colitis .

HY-112739

SC-41930	Leukotriene Receptor	Inflammation/Immunology
SC-41930 is a orally active eukotriene-B4 receptor antagonist. SC-41930 alleviates inflammation in guinea pig acetic acid-induced colonic inflammation model .

HY-173129

Anti-inflammatory agent 97	NF-κB Toll-like Receptor (TLR)	Inflammation/Immunology
Anti-inflammatory agent 97 (Compound 1l), an anti-inflammation agent, can also inhibit oxidative stress. Anti-inflammatory agent 97 can inhibit the colonic shortening and suppress inflammatory symptoms of the colonic tissue in the DSS (HY-116282C)-induced ulcerative colitis mice model. Anti-inflammatory agent 97 can regulate the inflammation-related TLR4/NF-κB signaling pathway and the oxidative stress-related Nrf2/HO-1 signaling pathway .

HY-15026

ATB 429	Endogenous Metabolite	Inflammation/Immunology
ATB-429, a novel H2S-releasing derivative of mesalamine, demonstrates significant anti-nociceptive and anti-inflammatory effects in models of irritable bowel syndrome (IBS). By releasing hydrogen sulfide (H2S), ATB-429 modulates colorectal distension-induced hypersensitivity in both healthy and postcolitic rats. It attenuates abdominal withdrawal responses and suppresses spinal c-Fos mRNA expression, indicating its potential to alleviate pain associated with gastrointestinal inflammation. Moreover, ATB-429 down-regulates colonic cyclooxygenase-2 and interleukin-1β mRNA expression, effects not observed with mesalamine alone. The mechanism involves ATP-sensitive K+ (KATP) channels, as evidenced by reversal of ATB-429's effects with glibenclamide. These findings suggest ATB-429 could offer therapeutic benefits for managing painful intestinal disorders linked to inflammation .

HY-W459577

Zinc picolinate	SOD	Inflammation/Immunology Cancer
Zinc picolinate is a zinc supplement. Zinc picolinate can mitigate colonic inflammation and enhances barrier function in a colitis rat. Zinc picolinate can inhibit uterine leiomyoma growth .

HY-179451

Apoptosis inducer 53	Apoptosis p38 MAPK Parasite	Infection Inflammation/Immunology Cancer
Apoptosis inducer 53 is an apoptosis inducer. Apoptosis inducer 53 can inhibit proliferation of human tumor cell lines (A549, HeLa, SW1573, T-47D, WiDr) with GI₅₀ values of 2.5-9.1 μM. Apoptosis inducer 53 can induce cancer cells apoptosis and reduce colony formation. Apoptosis inducer 53 can activate p38α MAPK signaling and exerts anti-inflammatory effect. Apoptosis inducer 53 also shows anti-Leishmania donovani activity. Apoptosis inducer 53 can be used for the researches of cancer, infection and inflammation .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990125

Anti-Mouse CSF1R/CD115 Antibody (AFS98)	c-Fms	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Anti-Mouse (CSF1R/CD115) Antibody (AFS98) is an anti-mouse CSF1R IgG2a antibody inhibitor derived from rats. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) inhibits M-CSF-dependent colony formation and cell growth by blocking the binding of M-CSF to its receptor. Anti-Mouse (CSF1R/CD115) Antibody (AFS98) can be used for the researches of inflammation, metabolic disease, cardiovascular disease and neurological disease, such as such as stroke, diabetes and arthritis .

HY-P99440

Anumigilimab CSL-324	c-Fms JAK STAT	Inflammation/Immunology
Anumigilimab (CSL-324) is an human IgG4 mAb against human *granulocyte colony-stimulating factor (G-CSF) receptor. Anumigilimab can be used for increasing numbers of neutrophils at sites of inflammation* .

Alkaline phosphatase, Bovine intestine 1 Publications Verification Apase	Structural Classification Natural Products Animals Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Endogenous Metabolite Phosphatase Glutathione Peroxidase Bacterial
Alkaline phosphatase, Bovine intestine (Apase) is an orally active membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase, Bovine intestine reduces myeloperoxidase activity and bacterial translocation. Alkaline phosphatase, Bovine intestine improves survival rate of mice infected with E. coli. Alkaline phosphatase, Bovine intestine improves TNBS-induced colon inflammation .

Coniferyl ferulate 1 Publications Verification	Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Dicerothamnus rhinocerotis Phenylpropanoids Umbelliferae Plants Disease Research Fields Source Classification Cancer	Glutathione S-transferase P-glycoprotein Apoptosis iGluR CaMK p38 MAPK Reactive Oxygen Species (ROS) Bacterial
Coniferyl ferulate is an orally active phenolic acid compound. Coniferyl ferulate is a potent inhibitor of glutathione S-transferase (GST) (IC₅₀ = 0.3 μM), which downregulates P-gp expression, induces apoptosis in B-MD-C1 (ADR+/+) cells, and reverses multidrug resistance. Coniferyl ferulate blocks the NMDAR/NR2B-CaMKII-MAPKs signaling pathway, inhibits ROS production and mitochondrial apoptosis, while reshapes the intestinal microbiota and microbial metabolism, ameliorates colonic inflammation and alleviates depressive symptoms in mice. Coniferyl ferulate can alleviate the toxicity of xylene to hematopoietic stem and progenitor cells by targeting Mgst2. Coniferyl ferulate exhibits antibacterial activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus .

PGE-M tetranor-PGEM	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	Drug Metabolite
PGE-M (tetranor-PGEM) is a metabolite of Prostaglandin E₂ (HY-101952) and also an inflammatory biomarker. Urinary PGE-M is a potential biomarker for detecting advanced colorectal tumors. PGE-M can be used in studies related to colorectal cancer, obesity, aging and breast cancer .

Arvelexin	Structural Classification Alkaloids Plants Brassicaceae Indole Alkaloids Source Classification	NF-κB Interleukin Related
Arvelexin is a biologically active compound. Arvelexin can be found in Brassica rapa L. (Brassicaceae). Arvelexin inhibits NF-κB activation and the expressions of IL-8. Arvelexin inhibits colonic inflammation .

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