77182-66-2
Chemical Structure
Isosilychristin
- CAS No.: 77182-66-2
- Formula:C25H22O10
- Molecular Weight:482.44
InChIKey: QYCJAWYDGRZSTO-IRLTUAEKSA-N
SMILES: OC[C@@H]1C2=C([C@H]3OC4=CC(O)=CC(O)=C4C([C@@H]3O)=O)C=CC(O)=C2O[C@H]1C5=CC(OC)=C(C=C5)O
Biological Activity: Isosilychristin is a P-glycoprotein inhibitor with an IC50 of 25.9 μM. Isosilychristin downregulates the expression of transmembrane efflux pumps, exerts intracellular antioxidant effects, and inhibits NO production in macrophages. Isosilychristin regulates cell cycle progression, and exerts weak antiproliferative and colony formation inhibitory effects in prostate cancer cells. Isosilychristin reduces bacterial intercellular communication and reverses the drug resistance of Staphylococcus aureus. Isosilychristin can be used in studies related to prostate cancer, inflammation and bacterial infections[1][2][3].
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Isosilychristin | Isosilychristin is a P-glycoprotein inhibitor with an IC50 of 25.9 μM. Isosilychristin downregulates the expression of transmembrane efflux pumps, exerts intracellular antioxidant effects, and inhibits NO production in macrophages. Isosilychristin regulates cell cycle progression, and exerts weak antiproliferative and colony formation inhibitory effects in prostate cancer cells. Isosilychristin reduces bacterial intercellular communication and reverses the drug resistance of Staphylococcus aureus. Isosilychristin can be used in studies related to prostate cancer, inflammation and bacterial infections. | |||||||||||||||||||||
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- [1]. Viktorová J, et al. Antioxidant, Anti-Inflammatory, and Multidrug Resistance Modulation Activity of Silychristin Derivatives. Antioxidants (Basel, Switzerland). 2019 Aug 14;8(8):303. [Content Brief]
- [2]. Deep G, et al. Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. International journal of cancer. 2008 Jul 01;123(1):41-50. [Content Brief]
- [3]. Holasová K, et al. Flavonolignans from silymarin modulate antibiotic resistance and virulence in Staphylococcus aureus. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 May;149:112806. [Content Brief]
Keywords
