194542-49-9
Chemical Structure
SM19712 free acid
- CAS No.: 194542-49-9
- Formula:C18H14ClN5O3S
- Molecular Weight:415.85
IUPAC Name: 4-chloro-N-((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)carbamoyl)benzenesulfonamide
InChIKey: CWLFPWRNPQXWLD-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C=C1)Cl)(NC(NC2=C(C(C)=NN2C3=CC=CC=C3)C#N)=O)=O
Biological Activity: SM19712 free acid is an orally active, selective endothelin converting enzyme (ECE) inhibitor. SM19712 free acid inhibits conversion of big ET-1 to ET-1. SM19712 free acid attenuates colonic angiogenesis, tissue injury, inflammation, without altering colon shortening or myeloperoxidase levels in mice. SM19712 free acid can be used for the research of inflammatory bowel disease (colitis), ischemic acute renal failure, acute myocardial infarction, and myocardial ischemia/reperfusion injury[1][2][3][4][5].
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SM19712 free acid | SM19712 free acid is an orally active, selective endothelin converting enzyme (ECE) inhibitor. SM19712 free acid inhibits conversion of big ET-1 to ET-1. SM19712 free acid attenuates colonic angiogenesis, tissue injury, inflammation, without altering colon shortening or myeloperoxidase levels in mice. SM19712 free acid can be used for the research of inflammatory bowel disease (colitis), ischemic acute renal failure, acute myocardial infarction, and myocardial ischemia/reperfusion injury. | |||||||||||||||||||||
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- [1]. Lee S, et al. Effects of the endothelin-converting enzyme inhibitor SM-19712 in a mouse model of dextran sodium sulfate-induced colitis. Inflamm Bowel Dis. 2009 Jul;15(7):1007-13. [Content Brief]
- [2]. Matsumura Y, et al. Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats. Jpn J Pharmacol. 2000 Sep;84(1):16-24. [Content Brief]
- [3]. Umekawa K, et al. Pharmacological characterization of a novel sulfonylureid-pyrazole derivative, SM-19712, a potent nonpeptidic inhibitor of endothelin converting enzyme. Jpn J Pharmacol. 2000 Sep;84(1):7-15. [Content Brief]
- [4]. Tawa M, et al. Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts. Eur J Pharmacol. 2008 Sep 4;591(1-3):182-8. [Content Brief]
- [5]. Labruijere et al, et al. Endothelin-converting-enzyme 1 inhibition and CGRP receptor recycling in human coronary and middle meningeal arteries. The Journal of Headache and Pain 2013 14(Suppl 1): P95.
Keywords
