55-45-8
Chemical Structure
McN-A-343
- CAS No.: 55-45-8
- Formula:C14H18Cl2N2O2
- Molecular Weight:317.21
IUPAC Name: 4-(((3-chlorophenyl)carbamoyl)oxy)-N,N,N-trimethylbut-2-yn-1-aminium chloride
InChIKey: CXFZFEJJLNLOTA-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(Cl)=CC=C1)OCC#CC[N+](C)(C)C.[Cl-]
Biological Activity: McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 produces a significant inhibitory effect on Muscarine (HY-121404)-evoked catecholamine secretion from the isolated perfused rat adrenal gland. McN-A-343 is involved in the regulation of neuronal firing and activates enteroendocrine L cells to release glucagon-like peptide 1 (GLP-1) and modulates the secretion of α-melanocyte stimulating hormone (α-MSH) from the pituitary gland in the central nervous system. McN-A-343 reduces colonic inflammation and oxidative stress in Acetic acid (HY-Y0319)-induced ulcerative colitis (UC) mice. McN-A-343 can be used for the study of ulcerative colitis[1][2][3].
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McN-A-343 | 99.89% | McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 produces a significant inhibitory effect on Muscarine (HY-121404)-evoked catecholamine secretion from the isolated perfused rat adrenal gland. McN-A-343 is involved in the regulation of neuronal firing and activates enteroendocrine L cells to release glucagon-like peptide 1 (GLP-1) and modulates the secretion of α-melanocyte stimulating hormone (α-MSH) from the pituitary gland in the central nervous system. McN-A-343 reduces colonic inflammation and oxidative stress in Acetic acid (HY-Y0319)-induced ulcerative colitis (UC) mice. McN-A-343 can be used for the study of ulcerative colitis. | ||||||||||||||||||||
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References
- [1]. Magalhães DA, et al. McN-A-343, a muscarinic agonist, reduces inflammation and oxidative stress in an experimental model of ulcerative colitis. Life Sci. 2021 May 1;272:119194. [Content Brief]
- [2]. Wakade AR, et al. McN-A-343, a specific agonist of M1-muscarinic receptors, exerts antinicotinic and antimuscarinic effects in the rat adrenal medulla. Life Sci. 1986 Dec 1;39(22):2073-80. [Content Brief]
- [3]. Mitchelson FJ. The pharmacology of McN-A-343. Pharmacol Ther. 2012 Aug;135(2):216-45. [Content Brief]
