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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
concentration ratio
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "concentration ratio" in MCE Product Catalog:
8
8 Publications Verification
Synonyms: Disodium bicinchoninate
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BCA is a chelating agent targeting Cu I. BCA forms a water-soluble complex with Cu I at a 2:1 stoichiometric ratio, which not only inhibits its oxidation and disproportionation reactions, but also mediates the Cu I-catalyzed azide-alkyne cycloaddition click chemistry reaction to achieve bioconjugation of fluorophores or biotin with functionalized proteins. BCA chelates Cu + from proteins that reduce Cu 2+, forming a purple compound detectable by colorimetry, and thus is used to determine the total protein concentration in solution. BCA is a potential small-molecule candidate for AHAS inhibitors .
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8 Publications Verification
Cat. No.: HY-W004599
CAS No.: 1245-13-2
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Bicinchoninic acid is a chelating agent targeting Cu I. Bicinchoninic acid forms a water-soluble complex with Cu I at a 2:1 stoichiometric ratio, which not only inhibits its oxidation and disproportionation reactions, but also mediates the Cu I-catalyzed azide-alkyne cycloaddition click chemistry reaction to achieve bioconjugation of fluorophores or biotin with functionalized proteins. Bicinchoninic acid chelates Cu + from proteins that reduce Cu 2+, forming a purple compound detectable by colorimetry, and thus is used to determine the total protein concentration in solution. Bicinchoninic acid is a potential small-molecule candidate for AHAS inhibitors .
8
8 Publications Verification
Cat. No.: HY-15908A
CAS No.: 63451-34-3
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Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate is a chelating agent targeting Cu I. Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate forms a water-soluble complex with Cu I at a 2:1 stoichiometric ratio, which not only inhibits its oxidation and disproportionation reactions, but also mediates the Cu I-catalyzed azide-alkyne cycloaddition click chemistry reaction to achieve bioconjugation of fluorophores or biotin with functionalized proteins. Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate chelates Cu + from proteins that reduce Cu 2+, forming a purple compound detectable by colorimetry, and thus is used to determine the total protein concentration in solution. Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate is a potential small-molecule candidate for AHAS inhibitors .
Cat. No.: HY-172550
CAS No.: 3095336-10-7
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MS7710 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel inhibitor with blood-brain barrier permeability and an excellent brain/plasma concentration ratio. MS7710 inhibits HCN channel-mediated Ih current, and reduces the firing frequency and burst activity of dopaminergic neurons in the ventral tegmental area. MS7710 ameliorates chronic social defeat stress-induced deficits in social interaction and impairments in reward-related cognitive flexibility in mice. MS7710 exerts only limited effects on ventral tegmental area dopaminergic neuron activity, social interaction, exploratory behavior, locomotor activity or sucrose preference in control mice. MS7710 is applicable to the research of major depressive disorder .
Cat. No.: HY-N4301
CAS No.: 30485-16-6
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Cat. No.: HY-D1590
CAS No.: 929679-22-1
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ODIPY Green 8-P2M is a novel thiol-reactive fluorescence probe based on the BODIPY fluorophore, the fluorescence is strongly quenched by d-PeT and then can be restored after reaction with thiol, resulting in an extremely high signal-to-noise ratio. ODIPY Green 8-P2M can be useful for detecting extremely low concentrations of protein in the gel after SDS-PAGE .
Cat. No.: HY-W111692
CAS No.: 68915-31-1
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4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain .
Cat. No.: HY-19478
CAS No.: 263248-16-4
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TAK-802 is an orally active and potent acetylcholinesterase inhibitor. TAK-802’s distribution in red blood cells has a significant concentration dependence, with the distribution ratio decreasing as the concentration increases. TAK-802 exhibits significant nonlinear pharmacokinetic behavior .
Cat. No.: HY-167825
CAS No.: 24506-68-1
Cat. No.: HY-B2150S
CAS No.: 65566-65-6
Synonyms: 4-Hydroxyphenazone-d3; NSC 174055-d3
Cat. No.: HY-172190A
Synonyms: 4-Hydroxyphenazone (Standard); NSC 174055 (Standard)
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4-Hydroxyantipyrine (Standard) is the analytical standard of 4-Hydroxyantipyrine. This product is intended for research and analytical applications. 4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain .
Cat. No.: HY-147397
CAS No.: 1346113-84-5
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PKM2 activator 3 is a potent PKM2 activator with an AC50 value of 90 nM. PKM2 activator 3 has good Caco-2 permeability, a low efflux ratio and high microsomal stability. PKM2 activator 3 can be used for researching anticancer .
(AC50: the concentration which gives 50% activation of enzyme.)
(AC50: the concentration which gives 50% activation of enzyme.)
Cat. No.: HY-N13710
CAS No.: 852567-75-0
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Sterculic acid methyl ester is an ester form of sterculic acid, which is an inhibitor of Δ9 desaturase. Sterculic acid methyl ester (0.75 mM) inhibits the growth of, and is toxic to, the bacteria R. opacus. It decreases the fatty acid content, increases the ratio of palmitate to other fatty acids, and decreases the levels of stearate and oleate in R. opacus when used at concentrations of 0.25 or 0.5 mM. Sterculic acid methyl ester (50 ppm) has a synergistic effect on increased tumor growth induced by aflatoxin Q1 in rainbow trout.
Cat. No.: HY-159938
p38α inhibitor 6 (compound 19) is a p38α inhibitor with the IC50 of 0.68 μM. p38α inhibitor 6 induces cell apoptosis and arrests cell cycle at G0 and G2/M phase. p38α inhibitor 6 decreases the TNF-α concentration as well as increased the expression of tumor suppressor gene p53, Bax/BCL-2 ratio and caspase 3/7 .
Cat. No.: HY-D3003
CAS No.: 2522921-17-9
Cat. No.: HY-121143
CAS No.: 73711-18-9
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Bis-Q is an acetylcholine (ACh) agonist that targets voltage-clamped muscle fibers of the fish Xenomystus nigris. Bis-Q exists in two forms: cis-Bis-Q (non-agonist) and trans-Bis-Q (agonist). Photoisomerization converts cis-Bis-Q to trans-Bis-Q, which induces agonist-induced currents. Channels activated by trans-Bis-Q and ACh have similar conductances and open times. Flashes increase the ratio of trans-Bis-Q to cis-Bis-Q until light equilibrium is reached. Further flashes transiently increase agonist-induced currents, indicating binding of trans-Bis-Q to desensitized receptors. Higher concentrations of cis-Bis-Q produce larger agonist-induced currents that decay exponentially. .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
