63451-34-3
![Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-15908a.gif "Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate Chemical Structure")
Chemical Structure
Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate
- CAS No.: 63451-34-3
- Formula:C20H10K2N2O4
- Molecular Weight:420.50
IUPAC Name: [2,2'-biquinoline]-4,4'-dicarboxylic acid, potassium salt
InChIKey: WCYSOCFXPUNTJG-UHFFFAOYSA-L
SMILES: O=C(C1=CC(C2=CC(C(O[K])=O)=C3C=CC=CC3=N2)=NC4=C1C=CC=C4)O[K]
Biological Activity: Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate is a chelating agent targeting CuI. Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate forms a water-soluble complex with CuI at a 2:1 stoichiometric ratio, which not only inhibits its oxidation and disproportionation reactions, but also mediates the CuI-catalyzed azide-alkyne cycloaddition click chemistry reaction to achieve bioconjugation of fluorophores or biotin with functionalized proteins. Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate chelates Cu+ from proteins that reduce Cu2+, forming a purple compound detectable by colorimetry, and thus is used to determine the total protein concentration in solution. Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate is a potential small-molecule candidate for AHAS inhibitors[1][2][3][4].
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Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate | Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate is a chelating agent targeting CuI. Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate forms a water-soluble complex with CuI at a 2:1 stoichiometric ratio, which not only inhibits its oxidation and disproportionation reactions, but also mediates the CuI-catalyzed azide-alkyne cycloaddition click chemistry reaction to achieve bioconjugation of fluorophores or biotin with functionalized proteins. Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate chelates Cu+ from proteins that reduce Cu2+, forming a purple compound detectable by colorimetry, and thus is used to determine the total protein concentration in solution. Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate is a potential small-molecule candidate for AHAS inhibitors. | |||||||||||||||||||||
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References
- [1]. Christen EH, et al. Evaluation of bicinchoninic acid as a ligand for copper(I)-catalyzed azide-alkyne bioconjugations. Organic & biomolecular chemistry. 2012 Sep 07;10(33):6629-32.
- [2]. Bublitz T A, et al. Optimization of the bicinchoninic acid assay for quantifying carbohydrates of soil extracellular polymeric substances. Plant and Soil, 2024, 498: 699‑709.
- [3]. Wang JG, et al. Identification of some novel AHAS inhibitors via molecular docking and virtual screening approach. Bioorg Med Chem. 2007 Jan 1;15(1):374-80. [Content Brief]
- [4]. Noble J E, et al. Chapter 8 Quantitation of Protein. In: Guide to Protein Purification, 2nd Edition. Methods in Enzymology, 2009, 463:73‑95.
