979-88-4
Chemical Structure
BCA
Synonym(s): Disodium bicinchoninate
- CAS No.: 979-88-4
- Formula:C20H10N2Na2O4
- Molecular Weight:388.28
IUPAC Name: sodium [2,2'-biquinoline]-4,4'-dicarboxylate
InChIKey: AUPXFICLXPLHBB-UHFFFAOYSA-L
SMILES: O=C(O[Na])C1=CC(C2=NC3=C(C=CC=C3)C(C(O[Na])=O)=C2)=NC4=C1C=CC=C4
Biological Activity: BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 value of 28 µM, a Ki value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD)[1][2][3].
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BCA | 99.99% | BCA (Disodium bicinchoninate) is an orally active and non-competitive Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 value of 28 µM, a Ki value of 43 µM. BCA shows anticancer activity. BCA has the potential for the research of Alzheimer's disease (AD). | ||||||||||||||||||||
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- [1]. Moon YJ, et al. Biochanin A inhibits breast cancer tumor growth in a murine xenograft model. Pharm Res. 2008 Sep;25(9):2158-63. [Content Brief]
- [2]. Hou Y, et al. Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice. Phytomedicine. 2022 Jun;100:154056. [Content Brief]
- [3]. Youn K, et al. The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor. Nutrients. 2016 Oct 14;8(10):637. [Content Brief]
Keywords
