979-88-4
Chemical Structure
BCA
Synonym(s): Disodium bicinchoninate
- CAS No.: 979-88-4
- Formula:C20H10N2Na2O4
- Molecular Weight:388.29
IUPAC Name: sodium [2,2'-biquinoline]-4,4'-dicarboxylate
InChIKey: AUPXFICLXPLHBB-UHFFFAOYSA-L
SMILES: O=C(O[Na])C1=CC(C2=NC3=C(C=CC=C3)C(C(O[Na])=O)=C2)=NC4=C1C=CC=C4
Biological Activity: BCA is a chelating agent targeting CuI. BCA forms a water-soluble complex with CuI at a 2:1 stoichiometric ratio, which not only inhibits its oxidation and disproportionation reactions, but also mediates the CuI-catalyzed azide-alkyne cycloaddition click chemistry reaction to achieve bioconjugation of fluorophores or biotin with functionalized proteins. BCA chelates Cu+ from proteins that reduce Cu2+, forming a purple compound detectable by colorimetry, and thus is used to determine the total protein concentration in solution. BCA is a potential small-molecule candidate for AHAS inhibitors[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BCA | 99.98% | BCA is a chelating agent targeting CuI. BCA forms a water-soluble complex with CuI at a 2:1 stoichiometric ratio, which not only inhibits its oxidation and disproportionation reactions, but also mediates the CuI-catalyzed azide-alkyne cycloaddition click chemistry reaction to achieve bioconjugation of fluorophores or biotin with functionalized proteins. BCA chelates Cu+ from proteins that reduce Cu2+, forming a purple compound detectable by colorimetry, and thus is used to determine the total protein concentration in solution. BCA is a potential small-molecule candidate for AHAS inhibitors. | ||||||||||||||||||||
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Similarity Score 0.85
![Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate Chemical Structure](//file.medchemexpress.com/product_pic/hy-15908a.gif)
HY-15908ADipotassium [2,2'-biquinoline]-4,4'-dicarboxylate -
Similarity Score 0.82
HY-W004599Bicinchoninic acid -
Similarity Score 0.66
HY-W0349594,4'-Dimethyl-2,2'-biquinoline -
Similarity Score 0.62
![8,8'-Dimethyl-[2,2'-biquinoline]-4,4'-dicarboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w1049808.gif)
HY-W10498088,8'-Dimethyl-[2,2'-biquinoline]-4,4'-dicarboxylic acid -
Similarity Score 0.60
HY-B0972RCinchophen (Standard) -
Similarity Score 0.57
HY-W010907Pamoic acid disodium -
Similarity Score 0.56
HY-W347485DHODH-IN-35 -
Similarity Score 0.55
HY-W103062R9-Acridinecarboxylic acid monohydrate (Standard) -
Similarity Score 0.55
HY-176224Anti-virulence factor-IN-2 -
Explore the MedChemAI to find more analogs
![Dipotassium [2,2'-biquinoline]-4,4'-dicarboxylate Chemical Structure](http://file.medchemexpress.com/product_pic/hy-15908a.gif)
![8,8'-Dimethyl-[2,2'-biquinoline]-4,4'-dicarboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w1049808.gif)
References
- [1]. Christen EH, et al. Evaluation of bicinchoninic acid as a ligand for copper(I)-catalyzed azide-alkyne bioconjugations. Organic & biomolecular chemistry. 2012 Sep 07;10(33):6629-32.
- [2]. Bublitz T A, et al. Optimization of the bicinchoninic acid assay for quantifying carbohydrates of soil extracellular polymeric substances. Plant and Soil, 2024, 498: 699‑709.
- [3]. Wang JG, et al. Identification of some novel AHAS inhibitors via molecular docking and virtual screening approach. Bioorg Med Chem. 2007 Jan 1;15(1):374-80. [Content Brief]
- [4]. Noble J E, et al. Chapter 8 Quantitation of Protein. In: Guide to Protein Purification, 2nd Edition. Methods in Enzymology, 2009, 463:73‑95.
