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cyanide antidote

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By Targets:	Biochemical Assay Reagents (1) Cytochrome P450 (1) Drug Intermediate (1) Endogenous Metabolite (3) Lactate Dehydrogenase (1) Reference Standards (2)
By Research Areas:	Metabolic Disease (1) Neurological Disease (1)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B2209

Hydroxocobalamin 3 Publications Verification Vitamin B12a	Endogenous Metabolite	Neurological Disease Metabolic Disease
Hydroxocobalamin (Vitamin B12a) is a cyanide antidote. Hydroxocobalamin can decrease the cell and plasma cyanide concentrations and increase survival rate in acute cyanide poisoning. Hydroxocobalamin can improve newborn Cbl-C defect-induced metabolic profile and neurocognitive outcome. Hydroxocobalamin can normalize Vitamin B₁₂ deficiency. Hydroxocobalamin can induce acute kidney injury. Hydroxocobalamin can be used for the researches of metabolic and neurological disease .

HY-34154

4-(Dimethylamino)phenol	Lactate Dehydrogenase	Others
4-(Dimethylamino)phenol is a potent cyanide antidote. 4-(Dimethylamino)phenol increases the extracellular lactate dehydrogenase (LDH) without markedly affecting gluconeogenesis. 4-(Dimethylamino)phenol cannot decreases the ATP content until the membrane becomes permeable to LDH. 4-(Dimethylamino)phenol’s toxicity is related to its reaction with glutathione and formation of covalent complexes, leading to impaired cellular function .

HY-122330

Dicobalt edetate Kelocyanor	Cytochrome P450	Others
Dicobalt edetate (Kelocyanor) is a cobalt compound that is an antidote for hydrocyanic acid (cyanide) poisoning. Dicobalt edetate can form a stable complex with cyanide ions, thereby reducing the binding of cyanide ions to cytochrome oxidase, thereby preventing cyanide from inhibiting cellular respiration .

HY-128454S

Dimethyl trisulfide-d6	Endogenous Metabolite	Others
Dimethyl trisulfide-d6 is deuterium labeled Dimethyl trisulfide (HY-128454). Dimethyl trisulfide is a cyanide antidote .

HY-W044686

4-(Dimethylamino)phenol hydrochloride	Biochemical Assay Reagents	Others
4-(Dimethylamino)phenol hydrochloride is a potent cyanide antidote. 4-(Dimethylamino)phenol hydrochloride binds to hemoglobin, and form methemoglobin. 4-(Dimethylamino)phenol hydrochloride can be used in cyanide poisoning research .

HY-169832

Sulfanegen	Drug Intermediate	Others
Sulfanegen is a 3-mercaptopyruvate prodrug and cyanide antidote. Sulfanegen converts toxic cyanide into a relatively non-toxic substance. Sulfanegen, alone or in combination with Cobinamide, has detoxification effect in mouse models of cyanide poisoning .

HY-128454R

Dimethyl trisulfide (Standard)	Reference Standards Endogenous Metabolite	Others
Dimethyl trisulfide (Standard) is the analytical standard of Dimethyl trisulfide. This product is intended for research and analytical applications. Dimethyl trisulfide is an organic chemical compound and the simplest organic trisulfide found in garlic, onion, broccoli, and similar plants. Dimethyl trisulfide is a cyanide antidote. Dimethyl trisulfide formation requires the thermal degradation of Met .

HY-34154R

4-(Dimethylamino)phenol (Standard)	Reference Standards	Others
4-(Dimethylamino)phenol (Standard) is the analytical standard of 4-(Dimethylamino)phenol. This product is intended for research and analytical applications. 4-(Dimethylamino)phenol is a potent cyanide antidote. 4-(Dimethylamino)phenol increases the extracellular lactate dehydrogenase (LDH) without markedly affecting gluconeogenesis. 4-(Dimethylamino)phenol cannot decreases the ATP content until the membrane becomes permeable to LDH. 4-(Dimethylamino)phenol’s toxicity is related to its reaction with glutathione and formation of covalent complexes, leading to impaired cellular function .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2209

Hydroxocobalamin 3 Publications Verification Vitamin B12a	Structural Classification Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Hydroxocobalamin (Vitamin B12a) is a cyanide antidote. Hydroxocobalamin can decrease the cell and plasma cyanide concentrations and increase survival rate in acute cyanide poisoning. Hydroxocobalamin can improve newborn Cbl-C defect-induced metabolic profile and neurocognitive outcome. Hydroxocobalamin can normalize Vitamin B₁₂ deficiency. Hydroxocobalamin can induce acute kidney injury. Hydroxocobalamin can be used for the researches of metabolic and neurological disease .

HY-128454R

Dimethyl trisulfide (Standard)	Structural Classification Natural Products Microorganisms Liliaceae Plants Endogenous metabolite A．Sativam L. var．Viviparum Regel Source Classification	Reference Standards Endogenous Metabolite
Dimethyl trisulfide (Standard) is the analytical standard of Dimethyl trisulfide. This product is intended for research and analytical applications. Dimethyl trisulfide is an organic chemical compound and the simplest organic trisulfide found in garlic, onion, broccoli, and similar plants. Dimethyl trisulfide is a cyanide antidote. Dimethyl trisulfide formation requires the thermal degradation of Met .

Cat. No.	Product Name	Chemical Structure

HY-128454S

Dimethyl trisulfide-d6
Dimethyl trisulfide-d6 is deuterium labeled Dimethyl trisulfide (HY-128454). Dimethyl trisulfide is a cyanide antidote .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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cyanide antidote

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