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eicosanoid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Biochemical Assay Reagents (3) COX (3) Cytochrome P450 (1) DAGL (3) Drug Intermediate (1) Drug Metabolite (2) Endogenous Metabolite (6) Integrin (1) Interleukin Related (2) Lipoxygenase (3) MAGL (1) Nucleoside Antimetabolite/Analog (1) PGE synthase (2) Phospholipase (1) PKA (2) PKC (1) Prostaglandin Receptor (3) Reference Standards (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (4) Endocrinology (1) Inflammation/Immunology (16) Metabolic Disease (3) Neurological Disease (1)
Oligonucleotides:	Phospholipids (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18540

KT109 1 Publications Verification	MAGL DAGL	Metabolic Disease Inflammation/Immunology
KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC₅₀ of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC₅₀=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-Arachidonoylglycerol (HY-W011051), Arachidonic acid (HY-109590) and eicosanoids in mouse peritoneal macrophages .

HY-113446

Leukotriene C4	Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation,allergy, bronchoconstriction, and vascular leakage .

HY-B0336

Pranoprofen 2 Publications Verification	COX Apoptosis PGE synthase	Inflammation/Immunology Cancer
Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis .

HY-113509

Lipoxin A4 1 Publications Verification LXA4	Interleukin Related Endogenous Metabolite	Inflammation/Immunology
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

HY-113439

12-HETE 2 Publications Verification	Apoptosis	Cardiovascular Disease Inflammation/Immunology
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

HY-W133891

Peptone from soya Peptones, soybean	Biochemical Assay Reagents	Others
Peptone from soy (peptones, soybean) is a peptone. Peptone from soy provides nitrogen and carbon sources, as well as other nutrients. Peptone from soy can stimulate/regulate the biosynthesis of cyclic eicosanoids. Peptone from soy induces dose-dependent contraction of guinea pig lung parenchyma. Peptone from soy can be used in microbial and cell culture .

HY-113481

Prostaglandin E3	Transmembrane Glycoprotein COX PKA Prostaglandin Receptor	Inflammation/Immunology Cancer
Prostaglandin E3 is an eicosanoid derived from eicosapentaenoic acid. Prostaglandin E3 inhibits polarization towards M1 but promotes polarization of M2a macrophages. Prostaglandin E3 shows anti-inflammatory and anti-tumor activity .

HY-113111

11,12-DiHETrE	Drug Metabolite	Inflammation/Immunology
11,12-DiHETrE is a dihydroxy fatty acid metabolite of Arachidonic Acid (HY-109590). 11,12-DiHETrE is converted to 11,12-DiHETrE under elevated soluble epoxide hydrolase (sEH) activity, a process closely related to inflammation and oxidative stress. 11,12-DiHETrE can serve as a single biomarker to differentiate between NAFL (non-alcoholic fatty liver disease) and NASH (non-alcoholic steatohepatitis). 11,12-DiHETrE can be used in studies on preterm birth, autism, and pulmonary hypertension .

HY-W011297

Methyl arachidonate Arachidonic acid methyl ester	PKC	Metabolic Disease
Methyl arachidonate is a protein kinase C activator and also an orally active substrate that undergoes esterase-mediated hydrolysis. Methyl arachidonate indirectly activates protein kinase C via eicosanoid metabolites generated through the arachidonic acid metabolic pathway, exerting effects via cyclooxygenase products at low concentrations and via lipoxygenase products at high concentrations. Methyl arachidonate can be used in studies related to lipodystrophy .

HY-126031

(R)-KT109	DAGL	Inflammation/Immunology
(R)-KT109 is a peripherally restricted serine hydrolase inhibitor that cannot cross the blood-brain barrier. (R)-KT109 irreversibly inhibits ABHD6, DAGLα and DAGLβ via carbamoylation of the active-site serine. (R)-KT109 exerts selective inhibitory effects on serine hydrolases in mouse brains, with pIC₅₀ values of 8.6, 9.1 and 8.2 against human ABHD6, DAGLα and DAGLβ, respectively. (R)-KT109 effectively reduces the levels of 2-arachidonoylglycerol, arachidonic acid, eicosanoids and TNF-α. (R)-KT109 is widely used in studies of metabolic syndrome-related diseases and neuroinflammation .

HY-W725399

1,2-Dilignoceroyl-sn-glycero-3-phosphocholine DLiPC; PC24	Drug Intermediate Endogenous Metabolite	Others
1,2-Dilignoceroyl-sn-glycero-3-phosphocholine (DLiPC) is a long-chain diacyl phospholipid characterized by its C24 saturated hydrocarbon chains and serves as a significant precursor for eicosanoids.

HY-130060

12(S)-HETrE	PKA Integrin	Cardiovascular Disease
12(S)-HETrE is a fatty acid metabolite that inhibits platelet aggregation. 12(S)-HETrE can be used in thrombosis-related research .

HY-150092

8(S),9(R)-EET	Drug Metabolite	Cardiovascular Disease
8(S),9(R)-EET is an eicosanoid product of Arachidonic acid (AA; HY-109590) by cytochromes P450. 8(S),9(R)-EET dilates canine epicardial arterioles in a concentration-dependent manner with an EC₅₀ value of 121 nM .

HY-116015

Dihomo-γ-Linolenic acid methyl ester	Endogenous Metabolite	Inflammation/Immunology
Dihomo-γ-Linolenic acid methyl ester is the methyl ester form of Dihomo-γ-Linolenic Acid (DGLA) (HY-A0143). Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is metabolized mainly through the cyclooxygenase (COX) pathway to the anti-inflammatory eicosanoid prostaglandin (PG) E1. Dihomo-γ-Linolenic acid has anti-inflammatory and antiproliferation effects .

HY-N3535

Canniprene	Prostaglandin Receptor Lipoxygenase	Inflammation/Immunology
Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC₅₀=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE₂; IC₅₀=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins .

HY-120621

BMS-229724	Phospholipase	Inflammation/Immunology
BMS-229724 is an orally active and tight-binding cytosolic phospholipase A₂ (cPLA₂) inhibitor with an IC₅₀ of 2.8 μM. BMS-229724 can inhibit the production of arachidonic acid and eicosanoids in U937 cells, neutrophils, platelets, and other cells. BMS-229724 has anti-inflammatory activity and can be used in the research of diseases such as skin inflammation .

HY-113509S

Lipoxin A4-d5 LXA4-d₅	Interleukin Related Endogenous Metabolite	Inflammation/Immunology
Lipoxin A4-d₅ is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

HY-130139

11,12-DiHETE	Cytochrome P450	Endocrinology
11,12-DiHETE is an orally active metabolite produced by cytochrome p450 mediated epoxide formation and subsequent epoxide hydrolase production .

HY-B0336R

Pranoprofen (Standard)	Reference Standards COX Apoptosis PGE synthase	Inflammation/Immunology Cancer
Pranoprofen (Standard) is the analytical standard of Pranoprofen. This product is intended for research and analytical applications. Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis .

HY-W339206

1,2-Dinonanoyl-sn-glycero-3-phosphocholine	Endogenous Metabolite	Others
1,2-Dinonanoyl-sn-glycero-3-phosphocholine, a specific phosphatidylcholine, features fatty acyl configurations that can influence the physical properties of membranes, making it a key component for generating eicosanoids. As a phospholipid abundant in membranes, it has fatty acids attached to glycerol at the sn-1 and sn-2 positions via ester bonds.

HY-174144

RJG-2036	Prostaglandin Receptor	Inflammation/Immunology
RJG-2036 is a potent covalent inhibitor of human prostaglandin reductase 2 (PTGR2)(IC₅₀=100 nM). RJG-2036 inhibits NADPH-dependent reduction, significantly reducing secretion of proinflammatory cytokines like TNF-α and multiple eicosanoids in LPS-stimulated THP-1 macrophages. RJG-2036 is promising for research of inflammatory diseases .

HY-113589

ICI 198615	Lipoxygenase	Inflammation/Immunology
ICI 198615 is a lipoxygenase inhibitor. ICI 198615 inhibits the activity of lipoxygenases involved in eicosanoid metabolism. ICI 198615 attenuates the early phase of bronchoconstriction induced by ET-1 .

HY-N15981

15(S)-HETE Cholesteryl ester	Biochemical Assay Reagents	Others
15(S)-HETE Cholesteryl ester is an eicosanoid.

HY-N15980

13(S)HODE Ethanolamide	Biochemical Assay Reagents	Others
13(S)HODE Ethanolamide is a eicosanoid.

HY-180616

(5Z,13E)-9Alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate 15-Dehydro-prostaglandin D2	Nucleoside Antimetabolite/Analog	Metabolic Disease
(5Z,13E)-9Alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate (15-Dehydro-prostaglandin D2) is a class of eicosanoids .

HY-113500A

Hepoxilin A3 HXA3	Lipoxygenase	Inflammation/Immunology
Hepoxilin A3 (HXA3) is a neutrophil chemo-attractant, synthesized by activating the PLA2-12-LOX pathway. Hepoxilin A3 can guide neutrophils to cross the epithelial barrier and migrate to the infection site (such as the alveolar cavity). The level of Hepoxilin A3 increases synchronously with neutrophil infiltration in mouse models. Hepoxilin A3 can be used to study inflammatory diseases (such as pneumonia, cystic fibrosis) .

HY-181482

A1480LS	DAGL	Neurological Disease
A1480LS is a peripherally restricted, orally active covalent and irreversible inhibitor of DAGLα and DAGLβ, with IC₅₀ values of 6 nM and 4 nM against human targets, respectively, and IC₅₀ values ≤15 nM across mouse, rat, dog, monkey and human systems. A1480LS reduces the levels of 2-arachidonoylglycerol, arachidonic acid, and cyclooxygenase- and lipoxygenase-derived eicosanoids. A1480LS inhibits injury-induced production of 2-arachidonoylglycerol and arachidonic acid in the peripheral sciatic nerve, and suppresses the responses of high-threshold and wide-dynamic-range-like dorsal horn neurons to mechanical stimulation. A1480LS alleviates pain behaviors in rat models of inflammatory pain, neuropathic pain and chemotherapy-induced peripheral neuropathy .

Peptone from soya Peptones, soybean	Biochemical Assay Reagents
Peptone from soy (peptones, soybean) is a peptone. Peptone from soy provides nitrogen and carbon sources, as well as other nutrients. Peptone from soy can stimulate/regulate the biosynthesis of cyclic eicosanoids. Peptone from soy induces dose-dependent contraction of guinea pig lung parenchyma. Peptone from soy can be used in microbial and cell culture .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113446

Leukotriene C4	Infection Natural Products Immune System Disorder Classification of Application Fields Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite
Leukotriene C4 is a eicosanoid lipid mediator and produced by immune cells during type 2 inflammation. Leukotriene C4 can mediate inflammation,allergy, bronchoconstriction, and vascular leakage .

HY-113509

Lipoxin A4 1 Publications Verification LXA4	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Interleukin Related Endogenous Metabolite
Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

HY-113439

12-HETE 2 Publications Verification	Microorganisms Source Classification	Apoptosis
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .

HY-150092

8(S),9(R)-EET	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Drug Metabolite
8(S),9(R)-EET is an eicosanoid product of Arachidonic acid (AA; HY-109590) by cytochromes P450. 8(S),9(R)-EET dilates canine epicardial arterioles in a concentration-dependent manner with an EC₅₀ value of 121 nM .

HY-116015

Dihomo-γ-Linolenic acid methyl ester	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Dihomo-γ-Linolenic acid methyl ester is the methyl ester form of Dihomo-γ-Linolenic Acid (DGLA) (HY-A0143). Dihomo-γ-Linolenic acid is an n-6 polyunsaturated fatty acid that is metabolized mainly through the cyclooxygenase (COX) pathway to the anti-inflammatory eicosanoid prostaglandin (PG) E1. Dihomo-γ-Linolenic acid has anti-inflammatory and antiproliferation effects .

HY-N3535

Canniprene	Monophenols Cannabis sativa L Classification of Application Fields Phenols Plants Moraceae Inflammation/Immunology Disease Research Fields Source Classification	Prostaglandin Receptor Lipoxygenase
Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC₅₀=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE₂; IC₅₀=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins .

HY-N15981

15(S)-HETE Cholesteryl ester	Lipid	Biochemical Assay Reagents
15(S)-HETE Cholesteryl ester is an eicosanoid.

HY-N15980

13(S)HODE Ethanolamide	Lipid	Biochemical Assay Reagents
13(S)HODE Ethanolamide is a eicosanoid.

HY-180616

(5Z,13E)-9Alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate 15-Dehydro-prostaglandin D2	Structural Classification Natural Products Endogenous metabolite Source Classification	Nucleoside Antimetabolite/Analog
(5Z,13E)-9Alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate (15-Dehydro-prostaglandin D2) is a class of eicosanoids .

Cat. No.	Product Name	Chemical Structure

HY-113509S

Lipoxin A4-d5
Lipoxin A4-d₅ is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

Lipoxin A4-d5

Lipoxin A4-d₅ is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties . Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways . Lipoxin A4 inhibits serum amyloid A (SAA)-mediated IL-8 release with an IC₅₀ value of 25.74 nM .

Cat. No.	Product Name		Classification

HY-W725399

1,2-Dilignoceroyl-sn-glycero-3-phosphocholine DLiPC; PC24		Phospholipids
1,2-Dilignoceroyl-sn-glycero-3-phosphocholine (DLiPC) is a long-chain diacyl phospholipid characterized by its C24 saturated hydrocarbon chains and serves as a significant precursor for eicosanoids.

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eicosanoid

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Isotope-Labeled Compounds

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