123931-39-5
123931-39-5
Chemical Structure
8(S),9(R)-EET
- CAS No.: 123931-39-5
- Formula:C20H32O3
- Molecular Weight:320.47
IUPAC Name: (Z)-7-((2S,3R)-3-((2Z,5Z)-undeca-2,5-dien-1-yl)oxiran-2-yl)hept-5-enoic acid
InChIKey: DBWQSCSXHFNTMO-ZZMPYBMWSA-N
SMILES: CCCCC/C=C\C/C=C\C[C@@H]1[C@@H](O1)C/C=C\CCCC(O)=O
Biological Activity: 8(S),9(R)-EET is an eicosanoid product of Arachidonic acid (AA; HY-109590) by cytochromes P450. 8(S),9(R)-EET dilates canine epicardial arterioles in a concentration-dependent manner with an EC50 value of 121 nM[1][2].
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8(S),9(R)-EET | 8(S),9(R)-EET is an eicosanoid product of Arachidonic acid (AA; HY-109590) by cytochromes P450. 8(S),9(R)-EET dilates canine epicardial arterioles in a concentration-dependent manner with an EC50 value of 121 nM. | |||||||||||||||||||||
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References
- [1]. D C Zeldin, et al. Epoxygenase pathways of arachidonic acid metabolism. J Biol Chem. 2001 Sep 28;276(39):36059-62. [Content Brief]
- [2]. Y Zhang, et al. EET homologs potently dilate coronary microvessels and activate BK(Ca) channels. Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2430-40. [Content Brief]
Keywords
