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Results for "

gap

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Gap Junction Protein (27) 11β-HSD (2) 5-HT Receptor (3) Amyloid-β (2) Antibiotic (3) AP-1 (1) Apoptosis (3) Bacterial (11) Bcl-2 Family (1) Biochemical Assay Reagents (3) Calcium Channel (1) Cannabinoid Receptor (1) Caspase (2) CHIKV (1) Claudin (1) Connexin (3) DNA/RNA Synthesis (2) Drug Derivative (2) Drug Intermediate (1) E1/E2/E3 Enzyme (1) EGFR (1) Endogenous Metabolite (19) Environmental Pollutants (5) ERK (1) Estrogen Receptor/ERR (1) Fat Mass and Obesity-associated Protein (FTO) (5) Fluorescent Dye (6) Fungal (1) GABA Receptor (1) GnRH Receptor (3) GSK-3 (1) HDAC (2) HIV (1) Hydroxycarboxylic Acid Receptor (HCAR) (8) Insecticide (1) Interleukin Related (2) Isotope-Labeled Compounds (7) Keap1-Nrf2 (1) Liposome (1) MEK (1) Microtubule/Tubulin (1) NF-κB (1) Oct3/4 (1) Orthopoxvirus (1) p38 MAPK (1) Phosphodiesterase (PDE) (1) Phosphoramidites (1) Potassium Channel (3) Progesterone Receptor (1) Proteasome (1) Raf (1) Ras (2) Reactive Oxygen Species (ROS) (1) Reference Standards (6) Reverse Transcriptase (1) RGS Protein (2) Small Interfering RNA (siRNA) (13) Tau Protein (1) TNF Receptor (2) Toll-like Receptor (TLR) (2) Topoisomerase (3) TRP Channel (1) β-catenin (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (12) Endocrinology (3) Infection (15) Inflammation/Immunology (25) Metabolic Disease (15) Neurological Disease (17)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) Cationic Lipids (1) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (7) Other Phosphoramidite (1) Phosphoramidites (1) siRNAs (13)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Gap Junction Protein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B2227

Lactic acid Maximum Cited Publications 52 Publications Verification DL-Lactic acid; E-270	Environmental Pollutants Endogenous Metabolite Bacterial Hydroxycarboxylic Acid Receptor (HCAR)	Infection Metabolic Disease Inflammation/Immunology Cancer
Lactic acid (DL-Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid also has antimicrobial activity, which can be used as a food preservative .

HY-B2227B

Lactic acid sodium (60% w/w in water) 50+ Cited Publications DL-Lactic acid sodium; E-270 sodium	Environmental Pollutants Endogenous Metabolite Bacterial Hydroxycarboxylic Acid Receptor (HCAR)	Infection Metabolic Disease Inflammation/Immunology Cancer
Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative . This product has a content (w/w) of 60%, and 1 mL of the system contains 798 mg of Lactic acid sodium, i.e., a concentration of 798 mg/mL (i.e., 7.12 M).

HY-128692

Luc Yellow CH dilithium 5 Publications Verification	Fluorescent Dye	Neurological Disease
Luc Yellow CH dilithium is a high-intensity fluorescent probe containing free hydrazyl groups. Luc Yellow CH can react with fatty aldehydes at room temperature. Luc Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Luc Yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .

HY-B1367

Carbenoxolone disodium 5+ Cited Publications	Gap Junction Protein Orthopoxvirus 11β-HSD	Infection Inflammation/Immunology
Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD . Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication . Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation. Carbenoxolone disodium inhibits Vaccinia virus replication.

HY-W127715

Lucifer Yellow CH dipotassium salt 5 Publications Verification	Fluorescent Dye	Others
Lucifer Yellow CH dipotassium is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .

HY-P0139

Gap 27 5+ Cited Publications	Gap Junction Protein	Cardiovascular Disease
Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment .

HY-117275

Meclofenamic acid 5+ Cited Publications Meclofenamate	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite	Neurological Disease Metabolic Disease Inflammation/Immunology
Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective *gap-junction* blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-15204

Tonabersat 15+ Cited Publications SB-220453	Gap Junction Protein	Neurological Disease Inflammation/Immunology
Tonabersat (SB-220453) is a *gap-junction* modulator. Tonabersat prevents inflammatory damage in the central nervous system .

HY-B1320

Meclofenamic acid sodium 5+ Cited Publications Meclofenamate sodium	Gap Junction Protein Endogenous Metabolite Fat Mass and Obesity-associated Protein (FTO)	Inflammation/Immunology Cancer
Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective *gap-junction* blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .

HY-A0170

Trovafloxacin 5+ Cited Publications	Bacterial Topoisomerase Antibiotic	Infection
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC₅₀ of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .

HY-103399

Trovafloxacin mesylate 5+ Cited Publications	Bacterial Topoisomerase Antibiotic	Infection
Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin mesylate blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin mesylate is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC₅₀ of 4 μM for PANX1 inward current. Trovafloxacin mesylate does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin mesylate leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1 .

HY-126247

BI-2852	Ras	Cancer
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

HY-P1136B

*TAT-Gap19* 1 Publications Verification	Gap Junction Protein	Cardiovascular Disease Inflammation/Immunology
TAT-Gap19, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 traverses the blood-brain barrier and alleviate liver fibrosis in mice .

HY-P1082

Gap 26 Maximum Cited Publications 8 Publications Verification	Connexin Gap Junction Protein	Cardiovascular Disease
Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .

HY-10913A

Danegaptide Hydrochloride 1 Publications Verification gap-134 Hydrochloride; ZP 1609 Hydrochloride	Gap Junction Protein	Cardiovascular Disease
Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active *gap-junction* modifier with an antiarrhythmic effect .

HY-106225

Rotigaptide 1 Publications Verification ZP123	Gap Junction Protein	Cardiovascular Disease
Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically atrial fibrillation .

HY-W010653

Antioxidant 1010 lrganox 1010; AT1010	Environmental Pollutants Biochemical Assay Reagents	Others
Antioxidant 1010 (lrganox 1010; AT1010) is a hindered phenolic antioxidant. Antioxidant 1010 does not inhibit intercellular gap-junctional communication. Antioxidant 1010 exhibits antioxidant efficacy in plastic, rubber and synthetic fiber .

HY-W010323

2,5-Dihydroxy-1,4-benzoquinone DHBQ	Endogenous Metabolite Fungal	Others
2,5-Dihydroxy-1,4-benzoquinone (DHBQ) is a redox-active quinone-based organic ligand with antibacterial activity that can be obtained from fungal metabolites. After 2,5-Dihydroxy-1,4-benzoquinone is incorporated into the Fe (dhbq) metal-organic framework, a two-electron redox process occurs, which helps improve the discharge capacity of Li ⁺-ion battery cathodes. 2,5-Dihydroxy-1,4-benzoquinone can be used to construct conductive metal-organic frameworks suitable for Li ⁺-ion battery cathodes .

HY-P1136

Gap19 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .

HY-B2227C

Lactic acid potassium 50+ Cited Publications DL-Lactic acid potassium; E-270 potassium	Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR) Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Lactic acid (DL-Lactic acid) potassium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid potassium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid potassium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid also potassium has antimicrobial activity, which can be used as a food preservative .

HY-B0327

Irsogladine 3 Publications Verification Dicloguamine	Phosphodiesterase (PDE) NF-κB AP-1 TRP Channel Interleukin Related	Inflammation/Immunology Cancer
Irsogladine (Dicloguamine) is an orally active gastric mucosal protective agent. Irsogladine inhibits breast cancer recurrence and lung metastasis in nude mice . Irsogladine inhibits the transcriptional activities of NF-κB and AP-1, suppresses the activities of PDE and PDE4 to elevate intracellular cAMP levels, and activates TRPV1 and K_ATP channels. Irsogladine enhances iNOS expression, NO production, and the activation of cAMP-responsive elements. Irsogladine inhibits the development and progression of intestinal polyps in Apc-mutant mice. Irsogladine alleviates oxidative stress, increases gastric mucosal blood flow, and stimulates the production of endogenous prostaglandins. Irsogladine promotes insulin secretion in MIN6 cells. Irsogladine inhibits tumor angiogenesis, cancer cell proliferation, and the production of proinflammatory cytokines. Irsogladine exerts protective effects on astrocytes in ethanol/hydrochloric acid-induced gastric ulcers in mice. Irsogladine prevents colitis in IL-10 gene-deficient mice by reducing the production of IL-12 and IL-23. Irsogladine upregulates gap junction intercellular communication in pancreatic cancer cells via the PKA pathway. Irsogladine is applicable to research related to breast cancer, intestinal polyposis, gastric ulcer, spontaneous colitis, glioma, liver cancer, and pancreatic cancer ^[5][6] .

HY-21242

MMT-hexylaminolinker phosphoramidite	Drug Intermediate Phosphoramidites	Others
MMT-Hexylaminolinker Phosphoramidite is a degradable linker and aminoalkylphosphoramidite monomer that can be used for the synthesis of oligonucleotide gap sequences or other nucleic acid molecules .

HY-B2227A

Lactic acid calcium 50+ Cited Publications DL-Lactic acid calcium; E-270 calcium	Environmental Pollutants Endogenous Metabolite Bacterial Hydroxycarboxylic Acid Receptor (HCAR)	Infection Neurological Disease Inflammation/Immunology Cancer
Lactic acid (DL-Lactic acid) calcium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid calcium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid calcium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid calcium also has antimicrobial activity, which can be used as a food preservative .

HY-B2227R

Lactic acid (Standard) DL-Lactic acid (Standard); E-270 (Standard)	Reference Standards Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR) Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Lactic acid (Standard) (DL-Lactic acid (Standard)) is the analytical standard of Lactic acid (HY-B2227). This product is intended for research and analytical applications. Lactic acid (DL-Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid also has antimicrobial activity, which can be used as a food preservative .

HY-159069

Zymosan (ZM), 95%	Toll-like Receptor (TLR) TNF Receptor Connexin	Infection Cancer
Zymosan (ZM), 95% is a yeast cell wall-derived carbohydrate-rich preparation and immunomodulator. Zymosan (ZM), 95% binds to and activates TLR-2, TLR-4, and Dectin-1 receptor to trigger downstream signaling pathways. Zymosan (ZM), 95% upregulates TLR-2, TLR-4, and TNF-α mRNA expression, increases serum TNF-α levels, and stimulates splenocyte number and viability in mice. Zymosan (ZM), 95% attenuates melanoma growth progression, modulates macrophage marker gene expression, and mediates phagocytosis, ROS generation, and cytokine production. Zymosan (ZM), 95% reduces Connexin 43 protein and mRNA levels, inhibits gap junctional intercellular communication, and induces proinflammatory factor production in human corneal cells. Zymosan (ZM), 95% induces peritoneal inflammation in mice, functions as a drug carrier, and supports fibroblast cell attachment in hydrogel formulations. Zymosan (ZM), 95% can be used for the research of melanoma, tumors, fungal keratitis, ocular surface inflammatory disorders, and peritoneal inflammation .

HY-P1136A

Gap19 TFA 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .

HY-P1174

*GnRH Associated Peptide (GAP) (1-13), human*	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-13), human is an amino acid peptide fragment derived from GnRH. GAP can increase the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in rat anterior pituitary cells. GAP also inhibit the secretion of prolactin .

HY-B2227BS

Lactic acid-d4 sodium (60% w/w in water) DL-Lactic acid-d4 sodium; E-270-d4 sodium	Isotope-Labeled Compounds Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR) Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Lactic acid-d₄ (DL-Lactic acid-d₄) sodium (60% in water) is the deuterium labeled Lactic acid sodium (60% in water) (HY-B2227B) . Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .

HY-B2227BS1

Lactic acid-d3 sodium (60% w/w in water) DL-Lactic acid-d3 sodium; E-270-d3 sodium	Isotope-Labeled Compounds Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR) Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Lactic acid-d₃ (DL-Lactic acid-d₃) sodium (60% in water) is the deuterium labeled Lactic acid sodium (60% in water) (HY-B2227B) . Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .

HY-P1082A

Gap 26 TFA Maximum Cited Publications 8 Publications Verification	Connexin Gap Junction Protein	Cardiovascular Disease
Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .

HY-P10886

Zifogaptide	Gap Junction Protein Claudin	Inflammation/Immunology
Zifogaptide is a gap junction protein channel regulator. Zifogaptide mimics the PDZ-binding motif at the C-terminal of Claudin C and competitively interferes with the interaction between Claudin–TJP1 (ZO-1) scaffold. Zifogaptide can promote epithelial cell migration, reduce scar formation, and accelerate wound healing. Zifogaptide can be used for radiation dermatitis, skin injuries, etc .

HY-B1588

Carbenoxolone	Amyloid-β Gap Junction Protein	Neurological Disease Metabolic Disease
Carbenoxolone is a blood-brain barrier-permeable Pannexin1 inhibitor, gap junction (Gap junction) blocker, and β-amyloid 42 inhibitor. Carbenoxolone modulates voltage-gated currents of wild-type and mutant Panx1, and inhibits stimulus-activated Panx1 channel function. Carbenoxolone interacts with stable residues of β-amyloid 42 peptides, fibrils and oligomers, thereby inhibiting their aggregation. Carbenoxolone alleviates liver fibrosis. Carbenoxolone exerts neuroprotective and nootropic effects. Carbenoxolone can be used in studies related to Alzheimer's disease and liver fibrosis .

HY-W248583

Pyrromethene 650 PM650	Fluorescent Dye	Others
Pyrromethene 650 (PM650) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.

HY-P3605

GnRH Associated Peptide (25-53), human gap (25-53), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-10913

Danegaptide gap-134; ZP 1609	Gap Junction Protein	Cardiovascular Disease
Danegaptide (GAP-134) is a potent, selective and orally active *gap-junction* modifier with an antiarrhythmic effect .

HY-P1136C

*TAT-Gap19 TFA* 1 Publications Verification	Gap Junction Protein	Cardiovascular Disease Inflammation/Immunology
TAT-Gap19 TFA, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 TFA does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 TFA traverses the blood-brain barrier and alleviate liver fibrosis in mice .

HY-175763

Z55660043	RGS Protein	Neurological Disease Metabolic Disease
Z55660043 is a Regulator of G protein signaling-14 (RGS14) inhibitor with an IC₅₀ of 2.3  μM. Z55660043 selectively and non-covalently inhibits RGS14 GTPase-accelerating protein (GAP) activity without measurable cytotoxicity. Z55660043 can be used for central nervous system and metabolic disorders research .

HY-D1777

Pyrromethene 605 PM605	Fluorescent Dye	Others
Pyrromethene 605 (PM605) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.

HY-B2227D

Calcium 2-hydroxypropanoate pentahydrate 10+ Cited Publications	Environmental Pollutants Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
Calcium 2-hydroxypropanoate (pentahydrate) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Calcium 2-hydroxypropanoate (pentahydrate) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Calcium 2-hydroxypropanoate (pentahydrate) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .

HY-126247B

(R)-BI-2852	Drug Derivative Ras	Cancer
(R)-BI-2852 is the isomer of BI-2852 (HY-126247), and can be used as an experimental control. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.

HY-P11197

ACT1	Gap Junction Protein	Cancer
ACT1 is a peptide that targets endogenous Cx43 by stabilizing its activity at gap junctions. ACT1 stabilizes gap junction intercellular communication in breast cancer cells. ACT1 enhances the activity of Tamoxifen (HY-13757A) and Lapatinib (HY-50898) in breast cancer. ACT1 can be used for breast cancer research .

HY-W104816

L-Tyrosyl-L-glutamic acid	DNA/RNA Synthesis	Others
L-Tyrosyl-L-glutamic acid is an amino acid penetrase *GAP1* inhibitor .

HY-W248118

Pyrromethene 556 PM556	Fluorescent Dye	Others
Pyrromethene 556 (PM556) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.

HY-N7424

4,7-Dihydroxycoumarin 4,7-DHC	EGFR Estrogen Receptor/ERR Progesterone Receptor	Cancer
4,7-Dihydroxycoumarin is an EGFR inhibitor, estrogen receptor inhibitor, and progesterone receptor inhibitor. 4,7-Dihydroxycoumarin against breast cancer cells with an IC₅₀ velue of 18.36 μg/mL. 4,7-Dihydroxycoumarin can be used for the research of breast cancer .

HY-P5389

Connexin mimetic peptide 40GAP27	Gap Junction Protein	Others
Connexin mimetic peptide 40GAP27 is a biological active peptide. (This peptide corresponds to the GAP27 domain of the second extracellular loop of dominant vascular connexin (Cx40), designated as 40Gap 27. It was used to investigate mechanisms through which oxidant stress impairs communication via gap junctions. When administered, 40Gap27attenuates endothelium-dependent subintimal smooth muscle hyperpolarization.)

HY-114865

BMS-192364	RGS Protein Calcium Channel	Neurological Disease
BMS-192364 is targeting the G_α-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux .

HY-106225R

Rotigaptide (Standard) ZP123 (Standard)	Reference Standards Gap Junction Protein	Cardiovascular Disease
Rotigaptide (Standard) is the analytical standard of Rotigaptide. This product is intended for research and analytical applications. Rotigaptide (ZP123) is a novel and specific modulator of connexin 43 (Cx43). Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress. Rotigaptide is a potent antiarrhythmic peptide (AAP) with improved stability and has the potential for the investigation of cardiac arrhythmias-specifically?atrial fibrillation .

HY-117275A

Meclofenamic acid sodium hydrate Meclofenamate sodium hydrate	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite	Neurological Disease Metabolic Disease Inflammation/Immunology
Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective *gap-junction* blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-153125

DLRIE	Liposome	Others
DLRIE is a cationic lipid that can be used for the synthesis of liposome GAP-DLRIE. GAP-DLRIE can be used to enhance the delivery and expression of plasmid DNA. DLRIE can be used for delivery of nucleic acids .

HY-W010653R

Antioxidant 1010 (Standard) lrganox 1010 (Standard); AT1010 (Standard)	Reference Standards Biochemical Assay Reagents	Others
Antioxidant 1010 (Standard) is the analytical standard of Antioxidant 1010 (lrganox 1010; AT1010) (HY-W010653) . This product is intended for research and analytical applications. Antioxidant 1010 is a hindered phenolic antioxidant. Antioxidant 1010 does not inhibit intercellular gap-junctional communication. Antioxidant 1010 exhibits antioxidant efficacy in plastic, rubber and synthetic fiber ..

Cat. No.	Product Name

HY-L209

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

1,961 compounds

The Ancient Chinese Classical Formulas, released by the State Administration of Traditional Chinese Medicine, selects the classic prescriptions from more than 100,000 prescriptions contained in more than 100 representative ancient medical books. Experts said that the classic prescription derived from ancient books, with thousands of years of human experience, is widely used in common diseases, frequented diseases, chronic diseases and other fields, and its development and utilization can fill the gap in medical drugs for some diseases in China, and effectively alleviate the increasingly severe medical needs brought by a series of social problems such as aging and chronic diseases in China. MCE has collected and sorted out these monomer compounds from the sources of ancient Chinese classical formulas, including licorice, ginseng, pinellia and other traditional Chinese medicine sources, which help to provide new ideas and new strategies for modern drug development.

MCE ancient Chinese classical formulas traditional Chinese medicine active compound library has 1,961 traditional Chinese medicine monomer compound, which can be used in the research fields of new drug development and drug target identification.

HY-LD005

DEL D Kit Cyclic Peptide Library

1.2 billion compounds

Cyclic peptide library have advantages such as high affinity, high selectivity, and suitability for targeting protein–protein interactions. Through DEL synthesis technology, the library size can achieve hundreds of millions. DEL cyclic peptide library have advantages like low cost andhigh screeing efficiency, making them valuable for discovering lead compounds against challenging drug targets.

This cyclic peptide library is constructed with unnatural amino acids as building block, synthesized through DNA-compatible chemical reactions. Each cyclic peptide consist of six amino acids and constrained conformations such as side-chain cross-linking, disulfide bonds, and macrocyclization. These cyclic peptides exhibit significantly improved stability and druggability compared with linear peptides, filling the gap between small molecules and macromolecular biologics. Each cyclic peptide is uniquely conjugated to a DNA barcode sequence for molecular identification and sequencing decoding.

MCE’s cyclic peptide library has8 independent sub-libraries, with a total molecular diversity of 1.2 billion. It is constructed via multi-round combinatorial assembly of building blocks and diverse cyclization strategies, facilitating the discovery of cyclic peptide leads for undruggable targets.

Cat. No.	Product Name	Type

HY-128692

Luc Yellow CH dilithium

5 Publications Verification

Fluorescent Dye

Luc Yellow CH dilithium is a high-intensity fluorescent probe containing free hydrazyl groups. Luc Yellow CH can react with fatty aldehydes at room temperature. Luc Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Luc Yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .

HY-W127715

Lucifer Yellow CH dipotassium salt

5 Publications Verification

Fluorescent Dye

Lucifer Yellow CH dipotassium is a high-intensity fluorescent probe containing free hydrazyl groups. Lucifer Yellow CH can react with fatty aldehydes at room temperature. Lucifer Yellow CH serves as a biological tracer to monitor neuronal branching, regeneration, gap junction detection and characterization, and selective ablation of cells after aldehyde fixation. Lucifer yellow CH displays the maximum excitation/emission of 430 nm/540 nm, respectively .

HY-W248583

Pyrromethene 650 PM650	Fluorescent Dye
Pyrromethene 650 (PM650) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.

HY-D1777

Pyrromethene 605 PM605	Fluorescent Dye
Pyrromethene 605 (PM605) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.

HY-W248118

Pyrromethene 556 PM556	Fluorescent Dye
Pyrromethene 556 (PM556) is a green-fluorescent polar tracer dye. It is used for investigations of membrane fusion, lysis, and gap-junctional communication and to detect volume changes in cells or liposomes.

HY-D2194

AgAuSe-COOH (1000 nm)	Fluorescent Dye
AgAuSe-COOH (1000 nm) is a fluorescent quantum dot that emits fluorescence in the near-infrared II region, with an emission peak reaching 1000 nm. AgAuSe-COOH (1000 nm) has the advantages of narrow band gap, large Stokes shift, and good photostability. AgAuSe-COOH (1000 nm) can bind proteins, antibodies, peptides, PEG, etc., and can be widely used in the field of biological imaging.

Cat. No.	Product Name	Type

HY-134136A

Octanoyl coenzyme A lithium	Biochemical Assay Reagents
Octanoyl coenzyme A lithium is an enoyl-CoA hydratase binder. Octanoyl coenzyme A lithium binds to the active site of enoyl-CoA hydratase, occupies the binding pocket for the fatty acid tail of the enzyme's substrate, and induces a conformational shift in a flexible protein loop via its longer octanoyl chain, forming an open channel leading to the inter-trimer gap .

HY-159069

Zymosan (ZM), 95%

Biochemical Assay Reagents

Zymosan (ZM), 95% is a yeast cell wall-derived carbohydrate-rich preparation and immunomodulator. Zymosan (ZM), 95% binds to and activates TLR-2, TLR-4, and Dectin-1 receptor to trigger downstream signaling pathways. Zymosan (ZM), 95% upregulates TLR-2, TLR-4, and TNF-α mRNA expression, increases serum TNF-α levels, and stimulates splenocyte number and viability in mice. Zymosan (ZM), 95% attenuates melanoma growth progression, modulates macrophage marker gene expression, and mediates phagocytosis, ROS generation, and cytokine production. Zymosan (ZM), 95% reduces Connexin 43 protein and mRNA levels, inhibits gap junctional intercellular communication, and induces proinflammatory factor production in human corneal cells. Zymosan (ZM), 95% induces peritoneal inflammation in mice, functions as a drug carrier, and supports fibroblast cell attachment in hydrogel formulations. Zymosan (ZM), 95% can be used for the research of melanoma, tumors, fungal keratitis, ocular surface inflammatory disorders, and peritoneal inflammation .

HY-B2227D

Calcium 2-hydroxypropanoate pentahydrate

10+ Cited Publications

Biochemical Assay Reagents

Calcium 2-hydroxypropanoate (pentahydrate) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Calcium 2-hydroxypropanoate (pentahydrate) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Calcium 2-hydroxypropanoate (pentahydrate) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity .

HY-134136

Octanoyl Coenzyme A	Biochemical Assay Reagents
Octanoyl coenzyme A is an enoyl-CoA hydratase binder. Octanoyl coenzyme A binds to the active site of enoyl-CoA hydratase, occupies the binding pocket for the fatty acid tail of the enzyme's substrate, and induces a conformational shift in a flexible protein loop via its longer octanoyl chain, forming an open channel leading to the inter-trimer gap .

Cat. No.	Product Name	Target	Research Area

HY-P0139

Gap 27 5+ Cited Publications	Gap Junction Protein	Cardiovascular Disease
Gap 27, a synthetic connexin43 mimetic peptide, is a gap junction inhibitor. Gap 27 possesses conserved sequence homology to a portion of the second extracellular loop leading into the fourth transmembrane connexin segment .

HY-P1136B

*TAT-Gap19* 1 Publications Verification	Gap Junction Protein	Cardiovascular Disease Inflammation/Immunology
TAT-Gap19, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 traverses the blood-brain barrier and alleviate liver fibrosis in mice .

HY-P1082

Gap 26 Maximum Cited Publications 8 Publications Verification	Connexin Gap Junction Protein	Cardiovascular Disease
Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .

HY-P1136

Gap19 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .

HY-P1136A

Gap19 TFA 5 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .

HY-P1174

*GnRH Associated Peptide (GAP) (1-13), human*	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-13), human is an amino acid peptide fragment derived from GnRH. GAP can increase the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in rat anterior pituitary cells. GAP also inhibit the secretion of prolactin .

HY-P1082A

Gap 26 TFA Maximum Cited Publications 8 Publications Verification	Connexin Gap Junction Protein	Cardiovascular Disease
Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif .

HY-P10886

Zifogaptide	Gap Junction Protein Claudin	Inflammation/Immunology
Zifogaptide is a gap junction protein channel regulator. Zifogaptide mimics the PDZ-binding motif at the C-terminal of Claudin C and competitively interferes with the interaction between Claudin–TJP1 (ZO-1) scaffold. Zifogaptide can promote epithelial cell migration, reduce scar formation, and accelerate wound healing. Zifogaptide can be used for radiation dermatitis, skin injuries, etc .

HY-P3605

GnRH Associated Peptide (25-53), human gap (25-53), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (25-53), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 25-53 fragment (hGAP-25-53), can be used as immunogen to generate antiseras including MC-1, MC-2, and MC-3. GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-P1136C

*TAT-Gap19 TFA* 1 Publications Verification	Gap Junction Protein	Cardiovascular Disease Inflammation/Immunology
TAT-Gap19 TFA, a Cx mimetic peptide, is a specific connexin43 hemichannel (Cx43 HC) inhibitor. TAT-Gap19 TFA does not inhibits the corresponding Cx43 GJCs. TAT-Gap19 TFA traverses the blood-brain barrier and alleviate liver fibrosis in mice .

HY-P11197

ACT1	Gap Junction Protein	Cancer
ACT1 is a peptide that targets endogenous Cx43 by stabilizing its activity at gap junctions. ACT1 stabilizes gap junction intercellular communication in breast cancer cells. ACT1 enhances the activity of Tamoxifen (HY-13757A) and Lapatinib (HY-50898) in breast cancer. ACT1 can be used for breast cancer research .

HY-P5389

Connexin mimetic peptide 40GAP27	Gap Junction Protein	Others
Connexin mimetic peptide 40GAP27 is a biological active peptide. (This peptide corresponds to the GAP27 domain of the second extracellular loop of dominant vascular connexin (Cx40), designated as 40Gap 27. It was used to investigate mechanisms through which oxidant stress impairs communication via gap junctions. When administered, 40Gap27attenuates endothelium-dependent subintimal smooth muscle hyperpolarization.)

HY-P3606

GnRH Associated Peptide (1-24), human gap (1-24), human	GnRH Receptor	Endocrinology
GnRH Associated Peptide (GAP) (1-24), human is the human gonadotropin-releasing hormone-associated peptide (GAP) 1-24 fragment (hGAP-1-24). GAP is joined to the luteinizing hormone-releasing hormone (LH-RH) sequence by a 3 amino acid processing site .

HY-P5387

Connexin mimetic peptide 40,37GAP26	Peptides	Others
Connexin mimetic peptide 40,37GAP26 is a biological active peptide. (This peptide corresponds to the GAP26 domain of the extracellular loop of the major vascular connexins (Cx37, Cx40), designated as 37, 40Gap 26 according to Cx homology. It was used to investigate the role of gap junctions in the spread of endothelial hyperpolarizations evoked by cyclopiazonic acid (CPA) through the wall of the rodent iliac artery. The gap junction plaques constructed from Cx37 and Cx40 were abundant in the endothelium. This peptide provides inhibitory effects against subintimal hyperpolarization.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2227

Lactic acid Maximum Cited Publications 52 Publications Verification DL-Lactic acid; E-270	Human Gut Microbiota Metabolites Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite Bacterial Hydroxycarboxylic Acid Receptor (HCAR)
Lactic acid (DL-Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid also has antimicrobial activity, which can be used as a food preservative .

HY-117275

Meclofenamic acid 5+ Cited Publications Meclofenamate	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite
Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective *gap-junction* blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-B1320

Meclofenamic acid sodium 5+ Cited Publications Meclofenamate sodium	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification Cancer	Gap Junction Protein Endogenous Metabolite Fat Mass and Obesity-associated Protein (FTO)
Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective *gap-junction* blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .

HY-B2227R

Lactic acid (Standard) DL-Lactic acid (Standard); E-270 (Standard)	Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Hydroxycarboxylic Acid Receptor (HCAR) Bacterial
Lactic acid (Standard) (DL-Lactic acid (Standard)) is the analytical standard of Lactic acid (HY-B2227). This product is intended for research and analytical applications. Lactic acid (DL-Lactic acid) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid also has antimicrobial activity, which can be used as a food preservative .

HY-117275A

Meclofenamic acid sodium hydrate Meclofenamate sodium hydrate	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite
Meclofenamic acid (Meclofenamate) sodium hydrate is a non-steroidal anti-inflammatory agent. Meclofenamic acid sodium hydrate is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid sodium hydrate competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid sodium hydrate is a non-selective *gap-junction* blocker. Meclofenamic acid sodium hydrate inhibits hKv2.1 and hKv1.1, with IC₅₀ values of 56.0 and 155.9 μM, respectively .

HY-117275R

Meclofenamic acid (Standard) Meclofenamate (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Fat Mass and Obesity-associated Protein (FTO) Potassium Channel Gap Junction Protein Endogenous Metabolite
Meclofenamic acid (Standard) is the analytical standard of Meclofenamic acid. This product is intended for research and analytical applications. Meclofenamic acid (Meclofenamate) is a non-steroidal anti-inflammatory agent. Meclofenamic acid is a highly selective FTO (fat mass and obesity-associated) enzyme inhibitor. Meclofenamic acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker. Meclofenamic acid inhibits hKv2.1 and hKv1.1, with IC50 values of 56.0 and 155.9 μM, respectively .

HY-B1320R

Meclofenamic acid sodium (Standard) Meclofenamate sodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Gap Junction Protein Endogenous Metabolite Fat Mass and Obesity-associated Protein (FTO)
Meclofenamic acid (sodium) (Standard) is the analytical standard of Meclofenamic acid (sodium). This product is intended for research and analytical applications. Meclofenamic acid (Meclofenamate) sodium is a non-steroidal anti-inflammatory agent (NSAID). Meclofenamic acid sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat - and obesity-related enzyme (FTO). Meclofenamic acid sodium has anti-inflammatory and antitumor activities .

Species:	Human (5) Bovine (1)
Tag:	SUMO (1) His (6)
Source:	HEK293 (1) E. coli Cell-free (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75175

	GAP43 Protein, Human (HEK293, His) Neuromodulin; pp46; gap43; B-50	Human	HEK293
	The GAP43 protein plays a central role in nerve growth and is found primarily in the active "growth cones" at the tips of axons. It induces axonal and dendritic filopodia, which are critical for neurodevelopmental dynamics. GAP43 Protein, Human (HEK293, His) is the recombinant human-derived GAP43 protein, expressed by HEK293 , with C-His labeled tag.

HY-P702287

	GJD2 Protein, Bovine (Cell-Free, His, SUMO) gap junction delta-2 protein; Connexin-36; Cx36; gap junction alpha-9 protein	Bovine	E. coli Cell-free
	GJD2 Protein, a connexin, aids in gap junction formation, where connexons create transmembrane channels. These channels allow direct intercellular communication by facilitating the diffusion of low molecular weight materials between adjacent cells. Each hexameric connexon, composed of connexins, plays a crucial role in exchanging essential substances among neighboring cells within gap junction clusters. GJD2 Protein, Bovine (Cell-Free, His, SUMO) is the recombinant bovine-derived GJD2 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag.

HY-P72205

	GJA1 Protein, Human (His) 1 Publications Verification Connexin 43; Connexin-43; Cx 43; Cx43; CXA1_HUMAN; DFNB38; gap junction 43 kDa heart protein; gap junction alpha-1 protein; gap junction protein alpha 1 43kDa connexin 43; ; gap junction protein alpha 1 43kDa; gap junction protein alpha like; GJA 1; Gja1; GJAL; ODD; ODDD; ODOD; SDTY3	Human	E. coli
	The GJA1 protein regulates bladder capacity through gap junctions, clusters of transmembrane channels that allow the diffusion of low molecular weight materials between adjacent cells. GJA1 protein also regulates NOV expression and localization and is important for ventricular gap junction communication. GJA1 Protein, Human (His) is the recombinant human-derived GJA1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71619

	SYNGAP1 Protein, Human (His) DKFZp761G1421 ; KIAA1938; MRD5; Neuronal Rasgap; OTTHUMP00000064825; p135 Syngap; Ras GTPase activating protein Syngap; Synaptic Ras-gap 1; SYNgap 1; SYNgap1	Human	E. coli
	SYNGAP1 protein is a major postsynaptic density component that plays a critical regulatory role in the Ras-cAMP pathway, affecting synaptic function and plasticity. At excitatory synapses, it is part of the NMDAR signaling complex and may influence NMDAR-dependent control of AMPAR potentiation, trafficking, and synaptic plasticity. SYNGAP1 Protein, Human (His) is the recombinant human-derived SYNGAP1 protein, expressed by E. coli , with N-His labeled tag.

HY-P702856

	G3BP1 Protein, Human (466a.a, His) G3BP-1; ATP-dependent DNA helicase VIII; hDH VIII; gap SH3 domain-binding protein 1	Human	E. coli
	G3BP1 Protein, Human (His) is the recombinant human-derived G3BP1, expressed by E. coli , with N-6*His labeled tag.

HY-P70997

	SUMO1 Protein, Human (His) Small Ubiquitin-Related Modifier 1; SUMO-1; gap-Modifying Protein 1; GMP1; SMT3 Homolog 3; Sentrin; Ubiquitin-Homology Domain Protein PIC1; Ubiquitin-Like Protein SMT3C; Smt3C; Ubiquitin-Like Protein UBL1; SUMO1; SMT3C; SMT3H3; UBL1	Human	E. coli
	SUMO1 Protein is a member of the SUMO (small ubiquitin-like modifier) protein family. SUMO1 binds to target proteins as part of a post-translational modification system. It is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. SUMO1 also regulates the function of several proteins via non-covalent interactions. SUMO1 Protein, Human (His) is the recombinant human-derived SUMO1 protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B2227BS

Lactic acid-d4 sodium (60% w/w in water)

Lactic acid-d₄ (DL-Lactic acid-d₄) sodium (60% in water) is the deuterium labeled Lactic acid sodium (60% in water) (HY-B2227B) . Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .

HY-B2227BS1

Lactic acid-d3 sodium (60% w/w in water)

Lactic acid-d₃ (DL-Lactic acid-d₃) sodium (60% in water) is the deuterium labeled Lactic acid sodium (60% in water) (HY-B2227B) . Lactic acid (DL-Lactic acid) sodium (60% w/w in water) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium (60% w/w in water) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium (60% w/w in water) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium (60% w/w in water) also has antimicrobial activity, which can be used as a food preservative .

HY-B1588S

Carbenoxolone-d4

Carbenoxolone-d₄ is deuterium labeled Carbenoxolone. Carbenoxolone, a semi-synthetic derivative of glycyrrhetinic acid, has previously been used for the management of dyspepsia and peptic ulcer because of its anti-inflammatory properties . Carbenoxolone, a general hemichannel and gap junction inhibitor, has the therapeutic potential of carbenoxolone in the research of chronic liver disease . Carbenoxolone is a suitable candidate for the inhibition of Aβ42 aggregation and the therapeutic potential of Cbx against AD . Carbenoxolone is small molecule Pannexin1 (Panx1,is an ATP release channel) inhibitor, attenuate Panx1 channel activity through modulation of the first extracellular loop .Carbenoxolone is an 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor that converts inactive glucocorticoid into an active form. Carbenoxolone has antiviral activity against DENV infection targeting the virus itself .

HY-10913S

Danegaptide-d5
Danegaptide-d₅ (GAP-134-d₅) is deuterium labeled Danegaptide. Danegaptide (GAP-134) is a potent, selective and orally active *gap-junction* modifier with an antiarrhythmic effect .

HY-15204S

Tonabersat-d6
Tonabersat-d₆ (SB-220453-d₆) is deuterium labeled Tonabersat. Tonabersat (SB-220453) is a *gap-junction* modulator. Tonabersat prevents inflammatory damage in the central nervous system .

HY-117275S1

Meclofenamic acid-13C6
Meclofenamic acid- ¹³C₆ is the ¹³C₆ labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker.

HY-117275S

Meclofenamic acid-d4
Meclofenamic acid-d₄ is the deuterium labeled Meclofenamic acid. Meclofenamic Acid (Meclofenamate), a non-steroidal, anti-inflammatory agent, is a highly selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic Acid competes with FTO binding for the m(6)A-containing nucleic acid. Meclofenamic acid is a non-selective gap-junction blocker .

HY-W769991

Lactate sodium-13C2

Lactic acid- ¹³C₂ (DL-Lactic acid- ¹³C₂) sodium is the ¹³C-labeled Lactic acid sodium . Lactic acid (DL-Lactic acid) sodium is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Lactic acid sodium is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Lactic acid sodium is an oncometabolite and has immune protective role of lactate in anti-tumor immunity . Lactic acid sodium also has antimicrobial activity, which can be used as a food preservative .

Host:	Mouse (9) Rabbit (18)
Reactivity:	Human (25) mouse (1) rat (1) Rat (19) Mouse (21) human (1)
Application:	IHC-P (17) ICC/IF (16) IF-Tissue (4) IP (9) IHC-F (7) WB (27) ChIP (1) FC (7) ELISA (10)
Isotype:	IgG (19) IgG1 (3) IgG/Kappa (1) IgG2b (3)
Conjugation:	Non-conjugated (27)
Clonality:	Polyclonal (1) Monoclonal (18) Recombinant (10)
Modification:	Unmodified (20)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83466

	RGS6 Antibody (YA3211) regulator of G protein signaling 6; gap; S914; HA117	WB	Human
	RGS6 Antibody (YA3211) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RGS6.

HY-P83466A

	RGS6 Antibody (YA3211)(PBS only) regulator of G protein signaling 6; gap; S914; HA117	WB	Human
	RGS6 Antibody (YA3211) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RGS6.

HY-P83136

	RACGAP1 Antibody (YA2881) CYK4; gap; gap1; ID gap; MgcRacgap; Racgap1	WB, IHC-P, ICC/IF	Human
	RACGAP1 Antibody (YA2881) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RACGAP1.

HY-P810294

	RACGAP1 Antibody (YA9637) CYK4; gap; gap1; ID gap; MgcRacgap; Racgap1	WB	Human, Mouse, Rat
	RACGAP1 Antibody (YA9637) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RACGAP1.

HY-P82081

	RAP1GAP Antibody (YA1826) RAP1gap; KIAA0474; RAP1GA1; Rap1 GTPase-activating protein 1; Rap1gap; Rap1gap1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	RAP1GAP Antibody (YA1826) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAP1GAP.

HY-P82081A

	RAP1GAP Antibody (YA1826)(PBS only) RAP1gap; KIAA0474; RAP1GA1; Rap1 GTPase-activating protein 1; Rap1gap; Rap1gap1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	RAP1GAP Antibody (YA1826) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAP1GAP.

HY-P86728

	GAP43 Antibody (YA6420) Growth Associated Protein-43; Neuromodulin; Axonal membrane protein gap 43; B-50; F1; gap 43; Growth Associated Protein 43; Nerve Growth Related Peptide; Neural phosphoprotein B 50; Neuromodulin; gap-43; pp46; NEUM_HUMAN; Protein F1; QtrA-11580; QtrA-13071.	WB, IHC-P, IHC-F, IF-Tissue, ICC/IF	Human, Mouse, Rat
	GAP43 Antibody (YA6420) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to GAP43.

HY-P83146

	GAP43 Antibody (YA2891) gap43; Neuromodulin; Axonal membrane protein gap-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	GAP43 Antibody (YA2891) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GAP43.

HY-P85729

	GAP43 Antibody (YA5421) gap43; Neuromodulin; Axonal membrane protein gap-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	GAP43 Antibody (YA5421) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to GAP43.

HY-P86401

	GAP43 Antibody (YA6093) gap43; Neuromodulin; Axonal membrane protein gap-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	GAP43 Antibody (YA6093) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GAP43.

HY-P86728A

	GAP43 Antibody (YA6420)(PBS only) Growth Associated Protein-43; Neuromodulin; Axonal membrane protein gap 43; B-50; F1; gap 43; Growth Associated Protein 43; Nerve Growth Related Peptide; Neural phosphoprotein B 50; Neuromodulin; gap-43; pp46; NEUM_HUMAN; Protein F1; QtrA-11580; QtrA-13071.	WB, IHC-P, IHC-F, IF-Tissue, ICC/IF	Human, Mouse, Rat
	GAP43 Antibody (YA6420) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to GAP43.

HY-P83146A

	GAP43 Antibody (YA2891)(PBS only) gap43; Neuromodulin; Axonal membrane protein gap-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	GAP43 Antibody (YA2891) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GAP43.

HY-P80628

	Connexin 43 Antibody Connexin 43; Connexin-43; Cx 43; Cx43; CXA1_HUMAN; DFNB38; gap junction 43 kDa heart protein; gap junction alpha-1 protein; gap junction protein alpha 1 43kDa (connexin 43); gap junction protein alpha 1 43kDa; gap junction protein alpha like; GJA 1; Gja1;	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Connexin 43 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Connexin 43.

HY-P84675

	ARFGAP1 Antibody (YA4372) ARF1gap; HRIHFB2281	WB, FC, ELISA	Human, Mouse
	ARFGAP1 Antibody (YA4372) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ARFGAP1.

HY-P810070

	*Rab 3 GAP* p150 Antibody (YA9414)**	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat
	Rab 3 GAP p150 Antibody (YA9414) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Rab 3 GAP p150.

HY-P86348

	Connexin 43 Antibody (YA6040) GJA1; GJAL; gap junction alpha-1 protein; Connexin-43; Cx43; gap junction 43 kDa heart protein	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Connexin 43 Antibody (YA6040) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Connexin 43.

HY-P84675A

	ARFGAP1 Antibody (YA4372)(PBS only) ARF1gap; HRIHFB2281	WB, FC, ELISA	Human, Mouse
	ARFGAP1 Antibody (YA4372) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to ARFGAP1.

HY-P82000

	GIT1 Antibody (YA1745) ARF gap GIT1; CAT 1; CaT1; GIT1	WB, FC	Human, Mouse, Rat
	GIT1 Antibody (YA1745) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GIT1.

HY-P84216

	CD49C Antibody (YA3913) ITGA3; VL3A; FRP-2; gapB3; ILNEB; MSK18; VCA-2; VLA3a; gap-B3	WB, FC, ELISA	Human
	CD49C Antibody (YA3913) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD49C.

HY-P84216A

	CD49C Antibody (YA3913)(PBS only) ITGA3; VL3A; FRP-2; gapB3; ILNEB; MSK18; VCA-2; VLA3a; gap-B3	WB, FC, ELISA	Human
	CD49C Antibody (YA3913) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD49C.

HY-P87098

	SynGAP Antibody (YA6791) DKFZp761G1421 antibody; KIAA1938 antibody; MRD5 antibody; Neuronal Rasgap antibody; OTTHUMP00000064825 antibody; p135 Syngap antibody; Ras GTPase activating protein Syngap antibody; Ras GTPase-activating protein Syngap antibody; RASA 1 antibody; RASA 5 antibody; DKFZp761G1421 antibody; KIAA1938 antibody; MRD5 antibody; Neuronal Rasgap antibody; OTTHUMP00000064825 antibody; p135 Syngap antibody; Ras GTPase activating protein Syngap antibody; Ras GTPase-activating protein Syngap antibody; RASA 1 antibody; RASA 5 antibody; RASA1 antibody; RASA5 antibody; SYGP1_HUMAN antibody; Synaptic Ras gap 1 antibody; Synaptic Ras GTPase activating protein 1 antibody; Synaptic Ras GTPase activating protein 1 homolog antibody; Synaptic Ras GTPase activating protein 135kDa antibody; Synaptic Ras GTPase activating protein antibody; Synaptic Ras GTPase-activating protein 1 antibody; Synaptic Ras-gap 1 antibody; SYNgap 1 antibody; SYNgap1 antibody;	WB, IHC-P, IF-Tissue	Mouse, Rat
	SynGAP Antibody (YA6791) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SynGAP.

HY-P85851

	G3BP Antibody (YA5543) Ras GTPase-activating protein-binding protein 1; G3BP-1; EC 3.6.4.13; ATP-dependent DNA helicase VIII; hDH VIII; gap SH3 domain-binding protein 1;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	G3BP Antibody (YA5543) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to G3BP.

HY-P82687

	G3BP Antibody (YA2432) G3BP1; G3BP; Ras GTPase-activating protein-binding protein 1; G3BP-1; ATP-dependent DNA helicase VIII; hDH VIII; gap SH3 domain-binding protein 1	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	G3BP Antibody (YA2432) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to G3BP.

HY-P80905

	SUMO1 Antibody (YA047) SUMO1; SMT3C; SMT3H3; UBL1; OK/SW-cl.43; Small ubiquitin-related modifier 1; SUMO-1; gap-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Smt3C; Ubiquitin-like protein	WB, IHC-P	Human, Mouse, Rat
	SUMO1 Antibody (YA047) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUMO1.

HY-P86396

	SUMO1 Antibody (YA6088) SUMO1; SMT3C; SMT3H3; UBL1; OK/SW-cl.43; Small ubiquitin-related modifier 1; SUMO-1; gap-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Smt3C; Ubiquitin-like protein	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	SUMO1 Antibody (YA6088) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUMO1.

HY-P80905A

	SUMO1 Antibody (YA047)(PBS only) SUMO1; SMT3C; SMT3H3; UBL1; OK/SW-cl.43; Small ubiquitin-related modifier 1; SUMO-1; gap-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Smt3C; Ubiquitin-like protein	WB, IHC-P	Human, Mouse, Rat
	SUMO1 Antibody (YA047) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUMO1.

HY-P80351

	SUMO1 Antibody (YA046) 2 Publications Verification DAP1 antibody; gap modifying protein 1 antibody; GMP 1 antibody; OFC10 antibody; PIC 1 antibody; PIC1 antibody; SENP2 antibody; Sentrin 1 antibody; Sentrin antibody; Small ubiquitin related modifier 1 antibody; Small ubiquitin-like modifier 1 antibody; Small ubiquitin-related modifier 1 antibody; SMT3 antibody; SMT3 homolog 3 antibody; SMT3 suppressor of mif two 3 homolog 1 antibody; SMT3, yeast, homolog 3 antibody; Smt3C antibody; SMT3H3 antibody; SUMO-1 antibody; SUMO1 antibody; SUMO1_HUMAN antibody; Ubiquitin homology domain protein PIC1 antibody; Ubiquitin Like 1 antibody; Ubiquitin like protein SMT3C antibody; Ubiquitin like protein UBL1 antibody; Ubiquitin-homology domain protein PIC1 antibody; Ubiquitin-like protein SMT3C antibody; Ubiquitin-like protein UBL1 antibody; UBL 1 antibody; UBL1 antibody	WB, ICC/IF, IHC-P, IP, FC, ChIP	Human, Mouse, Rat
	SUMO1 Antibody (YA046) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SUMO1.

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