23 Results for "

gene delivery vector

" in MedChemExpress (MCE) Product Catalog:
Products (23)

23 Results for "gene delivery vector" in MCE Product Catalog:

19
19 Cited Publications
Cat. No.: HY-W127378
CAS No.: 144189-73-1
Synonyms: 1,2-Dioleoyl-3-trimethylammonium-propane methylsulfate
DOTAP methylsulfat is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP methylsulfat promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP methylsulfat can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design .
loading...
    loading...
Cat. No.: HY-137131
CAS No.: 166023-21-8
Purity:  99.91%
Synonyms: DC-Cholesterol hydrochloride
DC-Chol hydrochloride is a cationic lipid. DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. DC-Chol hydrochloride induces the production of Th1 (IL-2 and IFN-γ) and Th2 (IL-5) cytokines. DC-Chol hydrochloride can enhance the body's immune response to antigens. DC-Chol hydrochloride is used as a gene delivery vector. DC-Chol hydrochloride can be used in research in areas such as hepatitis B vaccines to improve vaccine immunity .
loading...
    loading...
Cat. No.: HY-155882
CAS No.: 80506-64-5
Synonyms: mPEG750-NH2
mPEG750-amine (mPEG750-NH2) is a chemical modification reagent for nanoparticles, capable of covalently binding to Ad-PVA to form Ad-PVA-PEG polymers. mPEG750-amine stabilizes gene delivery complexes by providing steric hindrance, reducing particle aggregation, while enhancing the water solubility and serum stability of the complex, reducing carrier cytotoxicity, and assisting in the efficient condensation of pDNA by cationic components to form nanoparticles that can be endocytosed by cells. mPEG750-amine can also be used to synthesize folate-conjugated polymer micelles for encapsulating the anticancer agent Camptothecin (HY-16560). Folate-conjugated polymer micelles are effective carriers for poorly soluble anticancer drugs, capable of avoiding macrophages and acting through folate receptor (FR)-mediated endocytosis to target tumor cells. mPEG750-amine can be applied to research in the field of non-viral gene delivery, as a component of gene delivery vectors, facilitating the safe and efficient delivery of nucleic acid drugs to target cells .
loading...
    loading...
Cat. No.: HY-126437I
CAS No.: 25988-63-0
Poly-L-lysine hydrobromide (MW 1000-5000) is a homopolymer of L-lysine and a polycationic non-viral gene delivery vector. Poly-L-lysine hydrobromide (MW 1000-5000) forms complexes with plasmid DNA. Poly-L-lysine hydrobromide (MW 1000-5000) is applicable to relevant research on lung cancer .
loading...
    loading...
Cat. No.: HY-112624U
CAS No.: 9004-54-0
Synonyms: Dextran 20; Dextran D20; Dextran T20(MW 16000-24000)
Dextran T20 (Dextran 20; Dextran D20) (MW 20,000) is a dehydrated glucose polymer with an average molecular weight of 20,000. Dextran T20 (MW 20,000) has excellent biodegradability and good biocompatibility, and can be used as a gene delivery vector, an immune adjuvant carrier, and a hemoglobin stabilizer .
loading...
    loading...
Cat. No.: HY-168940B
CAS No.: 139729-28-5
NH2-PEG5000-COOH is a compound composed of an NH2 group, PEG units (MW = 2000) and a carboxyl group (-COOH) . NH2-PEG-COOH is widely used for surface modification and functionalization of polymer carriers or nanoparticles .
loading...
    loading...
Cat. No.: HY-147087
CAS No.: 1318793-78-0
Purity:  ≥98.0%
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
loading...
    loading...
Cat. No.: HY-P10991A
Synonyms: Stearylated octaarginine TFA
Research Areas:  

Others

Stearyl-(homoarginine)8 (Stearylated octaarginine) TFA is an effective gene delivery vector that can deliver plasmid DNA into cells. Stearyl-(homoarginine)8 TFA can make plasmid DNA more effectively internalized into cells and improve the nuclear delivery rate .
loading...
    loading...
Cat. No.: HY-149037A
Purity:  98.60%
Synonyms: N4-Spermine cholesteryl carbamate pentahydrochloride
GL67 pentahydrochloride (N4-Spermine cholesteryl carbamate pentahydrochloride) is a cationic lipid that serves as a non-viral siRNA delivery vector and a non-viral gene transfer vector. GL67 pentahydrochloride enhances the encapsulation efficiency of siRNA in liposomal formulations and promotes the cellular uptake of siRNA across cancer cell membranes. GL67 pentahydrochloride mediates the transduction of plasmid DNA into cells. GL67 pentahydrochloride can be used in drug delivery-related research .
loading...
    loading...
Cat. No.: HY-N3540
CAS No.: 354553-35-8
Caraphenol A is a resveratrol trimer and is able to transiently reduce interferon-induced transmembrane (IFITM) protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC50s of 5.9 μM and 12.1 μM, respectively .
loading...
    loading...
Cat. No.: HY-W322225
CAS No.: 59752-57-7
Synonyms: DLPE; 1,2-Dilauroyl-sn-glycero-3-PE
Target:  

Liposome

Research Areas:  

Others

1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE; 1,2-Dilauroyl-sn-glycero-3-PE) is an anionic phospholipid. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine promotes the endocytosis of liposome-DNA complexes into target cells, and subsequently mediates membrane fusion between liposome carriers and endosomes to deliver DNA into the nucleus. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is a component of anionic artificial viral envelope liposomes, which deliver plasmid DNA to hepatoma cells without serum inhibition. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine enables the construction of biocompatible non-viral gene delivery vector systems. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine is applicable for liposome synthesis .
loading...
    loading...
Cat. No.: HY-P10991
CAS No.: 383177-47-7
Synonyms: Stearylated octaarginine
Research Areas:  

Others

Stearyl-(homoarginine)8 (Stearylated octaarginine) is an effective gene delivery vector that can deliver plasmid DNA into cells. Stearyl-(homoarginine)8 can make plasmid DNA more effectively internalized into cells and improve the nuclear delivery rate .
loading...
    loading...
Cat. No.: HY-P10514
CAS No.: 678980-64-8
Research Areas:  

Others

Transportan 10 is a derivative of Transportan (HY-P1732) and is an amphiphilic cell penetrating peptide (CPP). Transportan 10 helps molecules penetrate cell membrane barriers by directly interacting with the lipid bilayer. Transportan 10 can be used in gene therapy or siRNA delivery vector research .
loading...
    loading...
Cat. No.: HY-168940
CAS No.: 139729-28-5
NH2-PEG1000-COOH is a compound composed of an NH2 group, PEG units (MW = 1000) and a carboxyl group (-COOH) . NH2-PEG-COOH is widely used for surface modification and functionalization of polymer carriers or nanoparticles .
loading...
    loading...
Cat. No.: HY-149037
CAS No.: 179075-30-0
Synonyms: N4-Spermine cholesteryl carbamate
GL67 (N4-Spermine cholesteryl carbamate) is a cationic lipid that serves as a non-viral siRNA delivery vector and a non-viral gene transfer vector. GL67 enhances the encapsulation efficiency of siRNA in liposomal formulations and promotes the cellular uptake of siRNA across cancer cell membranes. GL67 mediates the transduction of plasmid DNA into cells. GL67 can be used in drug delivery-related research .
loading...
    loading...
Cat. No.: HY-168940H
CAS No.: 139729-28-5
NH2-PEG5000-COOH is a compound composed of an NH2 group, PEG units (MW = 5000) and a carboxyl group (-COOH) . NH2-PEG-COOH is widely used for surface modification and functionalization of polymer carriers or nanoparticles .
loading...
    loading...
Cat. No.: HY-126721
CAS No.: 997-20-6
Research Areas:  

Others

Tetralysine is a cationic moietie that may be used in the construction of gene delivery vectors and DNA nanoparticles .
loading...
    loading...
Cat. No.: HY-168940D
CAS No.: 139729-28-5
NH2-PEG400-COOH is a compound composed of an NH2 group, PEG units (MW = 400) and a carboxyl group (-COOH) . NH2-PEG-COOH is widely used for surface modification and functionalization of polymer carriers or nanoparticles .
loading...
    loading...
Cat. No.: HY-168940E
CAS No.: 139729-28-5
NH2-PEG600-COOH is a compound composed of an NH2 group, PEG units (MW = 600) and a carboxyl group (-COOH) . NH2-PEG-COOH is widely used for surface modification and functionalization of polymer carriers or nanoparticles .
loading...
    loading...
Cat. No.: HY-168940C
CAS No.: 139729-28-5
NH2-PEG10000-COOH is a compound composed of an NH2 group, PEG units (MW = 10000) and a carboxyl group (-COOH) . NH2-PEG-COOH is widely used for surface modification and functionalization of polymer carriers or nanoparticles .
loading...
    loading...