NH2-PEG5000-COOH
NH2-PEG5000-COOH is a compound composed of an NH2 group, PEG units (MW = 5000) and a carboxyl group (-COOH). NH2-PEG-COOH is widely used for surface modification and functionalization of polymer carriers or nanoparticles.
For research use only. We do not sell to patients.
- CAS No.: 139729-28-5
- Molecular Weight:5000 (Average)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NH2-PEG-COOH is directly grafted onto the surface of PPI dendrimers via amide bonds, and the resulting modified vector reduces in vitro cytotoxicity, diminishes the sub-G1 apoptotic peak, and enhances gene transfection efficiency in neuroblastoma cells[1].
NH2-PEG3400-COOH can serve as a coupling unit for constructing PLGA-PEG-COOH copolymers, enabling PEGylation of the surface of NPs while retaining terminal -COOH groups for conjugation with targeting molecules[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 139729-28-5
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Molecular Weight 5000 (Average)
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SMILES
OC(COCCN)=O.[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Hashemi M, et al.. PEGylation of Polypropylenimine Dendrimer with Alkylcarboxylate Chain Linkage to Improve DNA Delivery and Cytotoxicity. Applied biochemistry and biotechnology. 2015 Sep;177(1):1-17. [Content Brief]
[2]. Betancourt T, et al.. PEGylation strategies for active targeting of PLA/PLGA nanoparticles. Journal of biomedical materials research. Part A. 2009 Oct;91(1):263-76. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NH2-PEG5000-COOH Related Classifications
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