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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
136 Results for "
guanylate
" in MedChemExpress (MCE) Product Catalog:
Products (136)
136 Results for "guanylate" in MCE Product Catalog:
30
30 Publications Verification
Synonyms: Basic Blue 9; CI-52015; Methylthioninium chloride
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27 Cited Publications
Cat. No.: HY-D0958
CAS No.: 122965-43-9
Synonyms: Basic Blue 9 hydrate; CI-52015 hydrate; Methylthioninium chloride hydrate
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Methylene blue (Basic Blue 9) hydrate is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue hydrate through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue hydrate is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue hydrate is a Tau aggregation inhibitor. Methylene blue hydrate reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .
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Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
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Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.
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Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.
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4 Cited Publications
Synonyms: BAY 58-2667 hydrochloride
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Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.
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3 Cited Publications
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BAY 41-2272 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research .
2
2 Cited Publications
Cat. No.: HY-17584
CAS No.: 851199-59-2
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Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase (sGC) activator. Praliciguat can increases cGMP via the nitric oxide (NO)-sGC pathway. Praliciguat can inhibit the expression of proinflammatory cytokines and inhibit apoptosis. Praliciguat can promote vasodilation. Praliciguat can be used for the researches of metabolic disease and cardiovascular disease, such as hypertension, diabetes and heart failure .
2
2 Cited Publications
Cat. No.: HY-W013386
CAS No.: 91300-60-6
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LY83583 is inhibitor of soluble guanylate cyclase (sGC) with the ability to target the cGMP signaling pathway. LY83583 inhibits the kinase activity-related proliferation of tumor cells by inducing the Cdk inhibitor p21. LY83583 can be used for the study of cancers (colorectal cancer, breast cancer and melanoma) and cardiovascular disease .
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2 Cited Publications
Cat. No.: HY-17584A
CAS No.: 851199-60-5
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Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects .
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Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator.
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Runcaciguat (BAY 1101042) is a selective, orally active, allosteric activator of soluble guanylate cyclase (sGC) that specifically targets its oxidized and heme-free form. Runcaciguat binds to sGC in a histidine-dependent manner and restores cyclic guanosine monophosphate (cGMP) production under oxidative stress, independent of nitric oxide (NO) or heme. Runcaciguat exhibits renoprotective and cardioprotective activities, such as reduced proteinuria and improved renal function. Runcaciguat is primarily being studied in chronic kidney disease (CKD) associated with hypertension, diabetes, and metabolic disorders, as well as potential cardiovascular indications such as heart failure with preserved ejection fraction (HFpEF) .
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Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay .
1
1 Cited Publications
Cat. No.: HY-P703074
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NPR1; ANPR-A; Prev. ANPRA; ANP-A; Prev. NPRA; GC-A; guanylate Cyclase A; Natriuretic Peptide Receptor A/guanylate Cyclase A (Atrionatriuretic Peptide Receptor A); GUCY2A; Natriuretic Peptide A Type Receptor; ANPa; Testicular Tissue Protein Li 20; Atrial N
1
1 Cited Publications
Cat. No.: HY-P72303
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NPR2; Atrial Natriuretic Peptide B-Type Receptor; Prev. ANPRB; Atrionatriuretic Peptide Receptor B; Prev. AMDM; Natriuretic Peptide Receptor B; Prev. NPRB; guanylate Cyclase; GC-B; ANPR-B; Atrial Natriuretic Peptide Receptor Type B; GUC2B; Atrial Natriure
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1
1 Cited Publications
Cat. No.: HY-P71666
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GUCY2C; Heat-Stable Enterotoxin Receptor; Prev. GUC2C; guanylate Cyclase 2C (Heat Stable Enterotoxin Receptor); STAR; Heat Stable Enterotoxin Receptor; GC-C; Alternative Protein GUCY2C; Guanylyl Cyclase C; DIAR6; STA Receptor; MECIL; HSER; MUCIL; GCC; HST
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Cardiovascular Disease Alkaloids other families Neurological Disease Plants Disease Research Fields Indole Alkaloids
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
