91300-60-6
91300-60-6
Chemical Structure
LY83583
- CAS No.: 91300-60-6
- Formula:C15H10N2O2
- Molecular Weight:250.26
IUPAC Name: 6-(phenylamino)quinoline-5,8-dione
InChIKey: GXIJYWUWLNHKNW-UHFFFAOYSA-N
SMILES: O=C1C=C(NC2=CC=CC=C2)C(C3=C1N=CC=C3)=O
Biological Activity: LY83583 is inhibitor of soluble guanylate cyclase (sGC) with the ability to target the cGMP signaling pathway. LY83583 inhibits the kinase activity-related proliferation of tumor cells by inducing the Cdk inhibitor p21. LY83583 can be used for the study of cancers (colorectal cancer, breast cancer and melanoma) and cardiovascular disease[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LY83583 | 99.84% | LY83583 is inhibitor of soluble guanylate cyclase (sGC) with the ability to target the cGMP signaling pathway. LY83583 inhibits the kinase activity-related proliferation of tumor cells by inducing the Cdk inhibitor p21. LY83583 can be used for the study of cancers (colorectal cancer, breast cancer and melanoma) and cardiovascular disease. | ||||||||||||||||||||
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LY83583 (Standard) | ≥98% | LY83583 (Standard) is the analytical standard of LY83583 (HY-W013386). This product is intended for research and analytical applications. LY83583 is inhibitor of soluble guanylate cyclase (sGC) with the ability to target the cGMP signaling pathway. LY83583 inhibits the kinase activity-related proliferation of tumor cells by inducing the Cdk inhibitor p21. LY83583 can be used for the study of cancers (colorectal cancer, breast cancer and melanoma) and cardiovascular disease. | ||||||||||||||||||||
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References
- [1]. Lodygin D, et al. Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner. J Clin Invest. 2002 Dec;110(11):1717-27. [Content Brief]
- [2]. Kontos HA, et al. Hydroxyl radical-dependent inactivation of guanylate cyclase in cerebral arterioles by methylene blue and by LY83583. Stroke. 1993 Mar;24(3):427-34. [Content Brief]
- [3]. Prasad RK, et al. LY-83583 stimulates glucose transporter-1-mediated glucose transport independent of changes in cGMP levels. Eur J Pharmacol. 1999 Jan 29;366(1):101-9. [Content Brief]
- [4]. Ribeiro AC, et al. The effects of intracerebroventricular application of 8-Br-cGMP and LY-83,583, a guanylyl cyclase inhibitor, on sleep-wake activity in rats. Brain Res. 2005 Jul 5;1049(1):25-33. [Content Brief]
Keywords
