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Pathways Recommended: Metabolic Enzyme/Protease
Results for "

human intestinal enzyme

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

2

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-Y1683
    DL-Menthol

    Racementhol

    		 Environmental Pollutants GABA Receptor Infection Neurological Disease
    DL-Menthol (Racementhol) is an orally active, GABAaR positive allosteric modulator and UDP-glucuronosyltransferase (UGT) inhibitor that can cross the blood-brain barrier. DL-Menthol binds to GABAAR and exhibits an allosteric activation effect, enhancing GABA-mediated chloride influx and inhibiting neuronal excitability. DL-Menthol can induce surgical anesthesia in fish and inhibit the metabolic detoxification of tobacco carcinogens by human liver and intestinal UGT enzymes, resulting in reduced NNAL-N-Gluc production .
    DL-Menthol
  • HY-130046
    16-Epiestriol

    16-epi-Estriol; 16β,17β-Estriol

    		 UGT Bacterial Infection Inflammation/Immunology
    16-Epiestriol (16-epi-Estriol; 16β,17β-Estriol) is a natural stereoisomer of estriol and an anti-inflammatory agent that targets UGT. The Ki values of 16-Epiestriol against human UGT1A10 and UGT2B7 are 98.1 μM and 162 μM, respectively. As a glucuronidation substrate, 16-Epiestriol can be modified at the 3-OH, 16-OH and 17-OH sites by various UGT enzymes; in liver microsomes, the modification mainly occurs at the 16-OH and 17-OH sites, while reactions take place at all three sites in intestinal microsomes. 16-Epiestriol acts on the phase II inflammatory process by blocking edema mediated by prostaglandins and leukocyte infiltration. It lacks glycogenic activity or any effect on blood glucose levels, and serves as an important candidate molecule in the research of inflammatory diseases .
    16-Epiestriol
  • HY-147388
    hiCE inhibitor-1

    		Cholinesterase (ChE) Metabolic Disease
    hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea .
    hiCE inhibitor-1
  • HY-121624
    Anthglutin

    		Glutathione S-transferase Infection
    Anthglutin is a gamma-glutamyltransferase inhibitor isolated from Penicillium oxalicum cultures. The Ki values of Anthglutin for different enzymes are: porcine kidney enzyme 5.7 μM, human kidney enzyme 18.3 μM, human liver soluble enzyme 13.6 μM, and conjugated enzyme 10.2 μM. Anthglutin had no significant effect on intestinal absorption of methionine in rats .
    Anthglutin
  • HY-E70968
    Enterokinase, Porcine

    		Endogenous Metabolite Metabolic Disease
    Enterokinase, Porcine (EC 3.4.21.9), is an enzyme produced by duodenal cells and participates in the digestive process in humans and animals. Enterokinase converts trypsinogen (an enzyme precursor) into its active form, trypsin, thereby activating pancreatic digestive enzymes. Deficiency of enterokinase can lead to intestinal digestive dysfunction.
    Enterokinase, Porcine
  • HY-130046R
    16-Epiestriol (Standard)

    16-epi-Estriol (Standard); 16β,17β-Estriol (Standard)

    		 Endogenous Metabolite Reference Standards Bacterial Infection Inflammation/Immunology
    16-Epiestriol (Standard) is the analytical standard of 16-Epiestriol (HY-130046). This product is intended for research and analytical applications. 16-Epiestriol (16-epi-Estriol; 16β,17β-Estriol) is a natural stereoisomer of estriol and an anti-inflammatory agent that targets UGT. The Ki values of 16-Epiestriol against human UGT1A10 and UGT2B7 are 98.1 μM and 162 μM, respectively. As a glucuronidation substrate, 16-Epiestriol can be modified at the 3-OH, 16-OH and 17-OH sites by various UGT enzymes; in liver microsomes, the modification mainly occurs at the 16-OH and 17-OH sites, while reactions take place at all three sites in intestinal microsomes. 16-Epiestriol acts on the phase II inflammatory process by blocking edema mediated by prostaglandins and leukocyte infiltration. It lacks glycogenic activity or any effect on blood glucose levels, and serves as an important candidate molecule in the research of inflammatory diseases .
    16-Epiestriol (Standard)

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