2654-68-4
2654-68-4
Chemical Structure
hiCE inhibitor-1
- CAS No.: 2654-68-4
- Formula:C18H14Cl2N2O4S2
- Molecular Weight:457.35
IUPAC Name: N,N'-(1,4-phenylene)bis(4-chlorobenzenesulfonamide)
InChIKey: DCKZGFRFXGBGOQ-UHFFFAOYSA-N
SMILES: ClC1=CC=C(S(=O)(NC2=CC=C(NS(=O)(C3=CC=C(Cl)C=C3)=O)C=C2)=O)C=C1
Biological Activity: hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea[1].
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hiCE inhibitor-1 | hiCE inhibitor-1, a sulfonamide derivative, is a selective human intestinal enzyme (hiCE) inhibitor with a Ki value of 53.3 nM. hiCE inhibitor-1 can be used to improve Irinotecan (HY-16562)-induced diarrhoea. | |||||||||||||||||||||
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References
- [1]. Randy M Wadkins, et al. Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity. Mol Pharmacol. 2004 Jun;65(6):1336-43. [Content Brief]
