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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
238 Results for "
interleukin 1
" in MedChemExpress (MCE) Product Catalog:
Products (238)
238 Results for "interleukin 1" in MCE Product Catalog:
56
56 Publications Verification
Synonyms: Kineret; Anakinra
Target:
Research Areas:
22
11
11 Cited Publications
Synonyms: IRAK-1/4 Inhibitor I
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IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.2 μM and 0.3 μM, respectively.
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10 Cited Publications
Cat. No.: HY-19975
CAS No.: 946387-07-1
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RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM) . RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells .
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7
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Zimlovisertib (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. Zimlovisertib is used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas .
7
7 Cited Publications
Cat. No.: HY-P81232
Synonyms: caspase-1 isoform alpha subunit; CASP1; ICE; IL1BC; Caspase-1 subunit p20; CASP 1; Caspase 1 apoptosis related cysteine peptidase; Caspase 1 apoptosis related cysteine protease; Caspase1; IL 1 beta converting enzyme; IL 1BC; IL1B convertase; IL1BCE; interleukin 1 beta convertase; interleukin 1 beta convertase precursor; interleukin 1 beta converting enzyme; CASP-1; interleukin-1 beta convertase; IL-1BC; interleukin-1 beta-converting enzyme; ICE; IL-1 beta-converting enzyme; p45; CASP1_HUMAN; CASP1_MOUSE.
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6 Cited Publications
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JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice . JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC50 of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 μM .
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6 Cited Publications
JH-X-119-01 hydrochloride is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 hydrochloride ameliorates LPS-induced sepsis in mice .
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6 Cited Publications
Cat. No.: HY-P1110
CAS No.: 185413-30-3
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2
2 Cited Publications
Cat. No.: HY-P72117
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CASP-1; CASP1; CASP1_HUMAN; Caspase 1; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1 beta converting enzyme; IL1B convertase; interleukin 1 beta convertase; interleukin 1B converting enzyme; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45
2
2 Cited Publications
Cat. No.: HY-P70455
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: interleukin-37; FIL1 Zeta; IL-1X; interleukin-1 Family Member 7; IL-1F7; interleukin-1 Homolog 4; IL-1H; IL-1H4; interleukin-1 Zeta; IL-1 Zeta; interleukin-1-Related Protein; IL-1RP1; interleukin-23; IL-37; IL37; FIL1Z; IL1F7; IL1H4; IL1RP1
2
2
1
1 Cited Publications
AZ1495, a weak base, is a potent orally active interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor. AZ1495 has a favorable physicochemical and kinase selectivity for IRAK4 and IRAK1 with IC50 values of 0.005 μM and 0.023 μM, respectively. AZ1495 has IRAK4 inhibition with a Kd value of 0.0007 μM. AZ1495 can be used for the research of diffuse large B-cell lymphoma (DLBCL) .
1
1 Cited Publications
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IRAK4-IN-4 (Compound 15) is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, with an IC50 of 2.8 nM. IRAK4-IN-4 also inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM. IRAK4-IN-4 can be used for research of autoimmune diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
