185413-30-3
Chemical Structure
AF12198
- CAS No.: 185413-30-3
- Formula:C96H123N19O22
- Molecular Weight:1895.12
InChIKey: VASLMBMCJADVGR-WTHHMRKISA-N
SMILES: O=C(N1[C@@H](CCC1)C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N2[C@@H](CC2)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@H](C(N)=O)CC(C)C)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)CC5=CC=C(C=C5)O)=O)CC6=CNC7=CC=CC=C67)=O)=O)[C@H]([C@H](O)C)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC8=CC=CC=C8)=O)=O)CC9=CNC%10=CC=CC=C9%10)=O
Biological Activity: AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AF12198 | 99.92% | AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC50=8 nM) but not the human type II receptor (IC50=6.7 µM) or the murine type I receptor (IC50>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC50=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC50=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo. | ||||||||||||||||||||
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