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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
86 Results for "
intramolecular
" in MedChemExpress (MCE) Product Catalog:
Products (86)
86 Results for "intramolecular" in MCE Product Catalog:
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5 Cited Publications
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LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding .
LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .
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5 Cited Publications
Cat. No.: HY-P1136
CAS No.: 1507930-57-5
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5 Cited Publications
Cat. No.: HY-P1136A
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1
1 Cited Publications
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UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM). UNC2541 abolishes the analgesic and anti-inflammatory effects of ozone in vivo and in vitro .
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1 Cited Publications
Cat. No.: HY-160528
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IBG3 is a Molecular glue degrader targeting BRD2 and BRD4, with DC50 values of 8.6 pM and 6.7 pM, respectively. IBG3 binds simultaneously to the tandem bromodomains of BRD2/BRD4, induces intramolecular conformational changes, enhances the affinity of BRD2/BRD4 for DCAF16, and promotes ubiquitination and degradation. IBG3 is applicable to the research of chronic myeloid leukemia .
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PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.
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L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of Homocysteine. Homocysteine thiolactone hydrochloride prevents translational incorporation of homocysteine into proteins. L-Homocysteine thiolactone hydrochloride can induce elevated HHcy (hyperhomocysteinemia) in mice .
Cat. No.: HY-W020768
CAS No.: 99685-96-8
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Fullerene-C60, a representative of carbon nanocompounds, is suggested to be promising agent for application in photodynamic research due to its unique physicochemical properties. Fullerene-C60 probes the intramolecular dynamics of its electron and energy transfer .
Cat. No.: HY-D2365
CAS No.: 304014-13-9
Cat. No.: HY-W012161
CAS No.: 3061-90-3
Synonyms: L-Alanyl-L-phenylalanine; H-Ala-Phe-OH
Cat. No.: HY-W012725
CAS No.: 367-27-1
Cat. No.: HY-W140203
CAS No.: 2963-66-8
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2-(2′-Hydroxyphenyl) benzimidazole is the most extensively studied excited-state intramolecular proton transfer (ESIPT) molecule, exhibiting normal and tautomer emissions. 2-(2′-Hydroxyphenyl) benzimidazole has been applied as a fluorescent probe in various systems .
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BETA-1 is the first twisted intramolecular charge transfer (TICT)-aggregation-induced emission (AIE) integration molecule. BETA-1 emits cyan fluorescence in lipid droplets (LDs) and red fluorescence in mitochondria. BETA-1 can be used for the simultaneous and dual-color imaging of LDs and mitochondria in vivo and in vitro .
Synonyms: ABAO
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2-Amino benzamidoxime (ABAO) acts as a bioconjugation reagent precursor and a fluorescent probe precursor. 2-Amino benzamidoxime contains an aniline group for imine activation of aldehydes, as well as a nucleophilic group (Nu:) located at the ortho position of the amine, which is responsible for intramolecular cyclization. 2-Amino benzamidoxime reacts with glyoxal at the N-terminus of phage-displayed peptide libraries. Derivatives of 2-Amino benzamidoxime can be used for protein bioconjugation. Derivatives of 2-Amino benzamidoxime serve as fluorescent probes .\n
Synonyms: 5-Formamidoimidazole-4-carboxamide ribotide
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Cat. No.: HY-W012017
CAS No.: 2507-55-3
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2-Hydroxytetradecanoic acid is a 2-hydroxy long-chain fatty acid and a sphingolipid component. 2-Hydroxytetradecanoic acid inhibits cleavage between the enterovirus capsid proteins VP4 and VP2. 2-Hydroxytetradecanoic acid exhibits antiviral activity .
Cat. No.: HY-E70421
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Peptide ligase is an Asx-specific asparaginyl endopeptidase (AEP) ligase and cyclase that can be isolated from the pods of butterfly pea (Clitoria ternatea). Peptide ligase mediates traceless intramolecular cyclization of polypeptides. Peptide ligase mediates intermolecular ligation of polypeptides or proteins. Peptide ligase can be used to cyclize food-derived angiotensin-converting enzyme (ACE) inhibitory peptides, thereby enhancing the stability and biological activity of ACE inhibitory peptides. Peptide ligase is applicable to relevant research in the fields of food and biopharmaceuticals .
Cat. No.: HY-W024271
CAS No.: 63149-33-7
Synonyms: 9-Formyl-8-hydroxyjulolidine
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8-Hydroxyjulolidine-9-carboxaldehyde (9-Formyl-8-hydroxyjulolidine) is a highly selective fluorescent probe for hydrogen sulfide (S 2−) and silicate (SiO3 2−). 8-Hydroxyjulolidine-9-carboxaldehyde operates via a mechanism of blocking intramolecular charge transfer (ICT), exhibiting significant fluorescence enhancement in the presence of weak acid ions. 8-Hydroxyjulolidine-9-carboxaldehyde is promising for research of fluorescence imaging of hydrogen sulfide within living cells .
Cat. No.: HY-34611
CAS No.: 25691-37-6
Synonyms: N-Boc-L-2,4-diaminobutyric acid; Boc-Dab-OH
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
