2 Results for "

isocoumarin derivative

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "isocoumarin derivative" in MCE Product Catalog:

1
Norbergenin
Norbergenin
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1 Cited Publications
Cat. No.: HY-N9447
CAS No.: 79595-97-4
Category:  

Natural Products other families Phenols Polyphenols Plants

Target:  

Free Radical Scavengers Tyrosine Hydroxylase Reactive Oxygen Species (ROS) Apoptosis NF-κB p38 MAPK STAT

Norbergenin is a polyphenolic isocoumarin derivative. Norbergenin acts as a non-competitive inhibitor of bovine adrenal tyrosine hydroxylase (TH) with a Ki value of 69.6 μM. Norbergenin inhibits lipopolysaccharide-induced inflammatory responses in macrophages by suppressing the activation of NF-κB, MAPK and STAT3, as well as blocking metabolic reprogramming . Norbergenin inhibits aluminum chloride-induced oxidative stress and apoptosis and restores neurocognitive parameters. Norbergenin scavenges ROS through multiple mechanisms and protects cell membranes from lipid peroxidation damage. Norbergenin can be used in research related to Alzheimer's disease, peptic ulcer and arthritis .
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Monocerin
Monocerin
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Cat. No.: HY-N6294
CAS No.: 30270-60-1
Category:  

Infection Microorganisms Monophenols Ketones, Aldehydes, Acids Phenols Disease Research Fields

Target:  

Bacterial Fungal

Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca .
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