Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
kinetoplastid
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "kinetoplastid" in MCE Product Catalog:
Synonyms: LXE408
Target:
Galeflaprit (LXE408) is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. Galeflaprit has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. Galeflaprit has a low propensity to cross the blood brain barrier. Galeflaprit has the potential for visceral leishmaniasis (VL) research .
Cat. No.: HY-131350A
CAS No.: 3026790-19-9
Synonyms: LXE408 fumarate
Target:
Research Areas:
Galeflaprit (LXE408) fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor.Galeflaprit fumarate has an IC50 of 0.04 μM for L. donovani proteasome and an EC50 of 0.04 μM for L. donovani. Galeflaprit fumarate has a low propensity to cross the blood brain barrier. Galeflaprit fumarate has the potential for visceral leishmaniasis (VL) research .
Cat. No.: HY-147940
CAS No.: 2499713-65-2
TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM) .
Cat. No.: HY-175305
CAS No.: 3052352-22-1
DMU759 is a Lysyl-tRNA synthetase 1 (KRS1) inhibitor. DMU759 has potent anti-kinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei and Leishmania donovani. DMU759 significantly reduces parasitemia in acute Chagas disease mice model. DMU759 can be used for parasitic infection like Chagas disease research .
Cat. No.: HY-168619
CAS No.: 272791-87-4
DNA crosslinker 6 (compound 1) is an anti-kinetoplastid compound. DNA crosslinker 6 has a strong ability to bind AT-DNA and can inhibit the binding of AT-hook 1 to DNA (IC50=0.03 µM). In addition, DNA crosslinker 6 also has antiprotozoal activity, with an EC50 value of 0.83 µM for the inhibition of T. brucei .
Cat. No.: HY-185309
CAS No.: 3094993-05-9
Target:
Research Areas:
Anti-Trypanosoma cruzi agent-9 is a topoisomerase II inhibitor. Anti-Trypanosoma cruzi agent-9 inhibits the growth of Trypanosoma cruzi and Leishmania donovani .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
