45 Results for "

membrane lipid structure

" in MedChemExpress (MCE) Product Catalog:
Products (45)

45 Results for "membrane lipid structure" in MCE Product Catalog:

11
11 Publications Verification
Cat. No.: HY-P1902
CAS No.: 115722-23-1
Cardiotoxin Analog (CTX) IV (6-12) is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity .
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11
11 Publications Verification
Cat. No.: HY-P1902A
CAS No.: 2918768-05-3
Cardiotoxin Analog (CTX) IV (6-12) TFA is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) TFA was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) TFA is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) TFA can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity .
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2
2 Cited Publications
Cat. No.: HY-135416
CAS No.: 98072-47-0
Streptolysin O is a cholesterol-targeting, thiol-activated pore-forming toxin. Streptolysin O binds to cholesterol via its C-terminal domain 4, oligomerizes to form arc-shaped or ring-shaped structures, inserts amphipathic helices into the lipid bilayer, and forms transmembrane β-barrel pores, resulting in cell permeabilization. Streptolysin O enables controllable cell membrane permeabilization, fluorescent probe delivery, and exogenous molecule uptake .
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1
1 Cited Publications
Cat. No.: HY-W583868
CAS No.: 26662-94-2
Synonyms: 1,2-POPE; 16:0-18:1 PE
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines .
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1
1 Cited Publications
Cat. No.: HY-P5712
CAS No.: 113-73-5
Synonyms: Gramicidin soviet
Research Areas:  

Infection

Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na +/K +-ATPase, tobacco leaf plasma membrane Mg 2+/K +-ATPase, and rat heart plasma membrane Ca 2+-ATPase, respectively .
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1
1 Cited Publications
Cat. No.: HY-135416A
CAS No.: 98072-47-0
Purity:  ≥96.0%
Recombinant Streptolysin O is a cholesterol-targeting, thiol-activated pore-forming toxin. Recombinant Streptolysin O binds to cholesterol via its C-terminal domain 4, oligomerizes to form arc-shaped or ring-shaped structures, inserts amphipathic helices into the lipid bilayer, and forms transmembrane β-barrel pores, resulting in cell permeabilization. Recombinant Streptolysin O enables controllable cell membrane permeabilization, fluorescent probe delivery, and exogenous molecule uptake .
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1
1 Cited Publications
Cat. No.: HY-N2382
CAS No.: 81917-50-2
Polyphyllin H is a steroidal saponin. Polyphyllin H is isolated from Paris polyphylla. Polyphyllin H potently inhibits the activities of CYP1A2 (IC50 = 6.44 μM, competitive), CYP2D6 (IC50 = 13.88 μM, competitive) and CYP3A4 (IC50 = 4.52 μM, non-competitive, time-dependent). Polyphyllin H downregulates the expression of ABCB1 and ABCC3. Polyphyllin H binds to membrane cholesterol and disrupts lipid raft structures. Polyphyllin H restores the sensitivity of paclitaxel-resistant breast cancer cells to paclitaxel .
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1
1 Cited Publications
Cat. No.: HY-W073074
CAS No.: 68938-72-7
Mesoporphyrin IX (dihydrochloride) is a photosensitizer that can be used to modify liposomes. Mesoporphyrin IX (dihydrochloride) can insert into lipid vesicles and disrupt the viral membrane structure in vesicular stomatitis virus (VSV), inducing cross-linking of VSV glycoproteins, thereby inhibiting viral activity .
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Cat. No.: HY-141613
CAS No.: 90693-88-2
Purity:  ≥98.0%
Synonyms: DOPS-NA
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium (DOPS-NA) is a ubstitute for Phosphoserine/phosphatidylserine. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium can be used together with DOPC and DOPE in lipid mixtures for the synthesis of liposomes. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium can self-assemble into single-layer or double-layer membrane structures, similar to cell membranes, and possesses high membrane fluidity and flexibility. 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine is widely applied in membrane biology, cell membrane research, lipid preparation, and drug delivery systems .
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Cat. No.: HY-D1736
CAS No.: 158757-82-5
BODIPY FL-C16 is a BODIPY-labeled analog of Palmitic acid (HY-N0830), which serves as a fluorescent lipid tracer. BODIPY FL-C16 also acts as a ligand for liver fatty acid-binding protein (L-FABP) and intestinal fatty acid-binding protein (I-FABP) , with Kd values of 270 nM and 330 nM, respectively. BODIPY FL-C16 is rapidly taken up by cells, and after metabolic conversion to phospholipids, it is incorporated into the membrane structures of intracellular organelles and extracellular vesicles .
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Cat. No.: HY-162543
CAS No.: 384833-00-5
Synonyms: 18:1 Lissamine rhodamine PE
Target:  

Fluorescent Dye

Research Areas:  

Others

18:1 Liss Rhod (18:1 Lissamine rhodamine) PE is a fluorescent phospholipid and fluorescent probe.18:1 Liss Rhod PE admixes into phospholipid inks for large-scale monitoring of dip-pen nanolithography-generated lithographic structures via fluorescence microscopy.18:1 Liss Rhod PE undergoes phase separation or self-quenching under certain conditions in thin lipid membrane stacks .
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Cat. No.: HY-B2167R
CAS No.: 6217-54-5
Synonyms: DHA (Standard); Cervonic acid (Standard)
Docosahexaenoic acid (Standard) is the analytical standard of Docosahexaenoic acid. This product is intended for research and analytical applications. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk. In Vitro: Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. The inclusion of plentiful DHA in the diet improves learning ability and memory . DHA is an essential requirement in every step of brain development like neural cell proliferation, migration, differentiation, synaptogenesis. The multiple double bonds and unique structure allow DHA to impart special membrane characteristics for effective cell signaling. Many development disorders like dyslexia, autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia etc. are causally related to decreased level of DHA . DHA is a potent RXR ligand inducing robust RXR activation already at low micro molar concentrations. The EC50 for RXRα activation by DHA is about 5-10 μM fatty acid . In Vivo: Docosahexaenoic acid administration over 10 weeks significantly reduces the number of reference memory errors, without affecting the number of working memory errors, and significantly increases the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex . DHA treatment exerts neuroprotective actions on an experimental mouse model of PD. There is a decrease tendency in brain lipid oxidation of MPTP mice but it does not significantly .
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Cat. No.: HY-145795
CAS No.: 1883431-67-1
Purity:  ≥98.0%
OF-02 is an ionizable lipid for mRNA delivery and a key component of lipid nanoparticles (LNPs). OF-02 is protonated in the acidic endosomal environment to promote endosomal escape of mRNA and efficiently induce protein expression in target cells. OF-02 relies on the pH-responsive membrane fusion properties to form a complex with mRNA and destroy the endosomal membrane structure to achieve mRNA release in the cytoplasm. OF-02 is mainly used in the development of mRNA vaccines, gene editing, and protein replacement therapy[1][2][3].
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Cat. No.: HY-107343
CAS No.: 81926-94-5
Purity:  96.22%
Synonyms: Ethyl docosahexaenoate
Target:  

COX

Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects .
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Cat. No.: HY-148978
CAS No.: 321883-23-2
Purity:  99.62%
18:0,18:1 PS sodium is the dominant phosphatidylserine subtype in cells, exosomes and HIV particles. It is abundant in the brain and is essential for maintaining membrane structure, lipid raft organization and intracellular trafficking. 18:0,18:1 PS sodium mediates interleaflet membrane coupling through cholesterol-dependent interactions with very long-chain sphingolipids, and can induce the clustering of glycosylphosphatidylinositol-anchored proteins. In addition, clusters formed by the binding of 18:0,18:1 PS sodium to cholesterol not only facilitate the proper distribution of cholesterol in lipid bilayers, but also effectively protect cholesterol from oxidative damage .
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Cat. No.: HY-165029
CAS No.: 17708-90-6
Synonyms: PLPC
Target:  

Liposome

1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC (PLPC) is a phosphatidylcholine phospholipid. 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC and oxidized derivatives serve as models for investigating lipid peroxidation, membrane structure, and phospholipase A2 activity. 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC can be applied in research on atherosclerosis, oxidative stress, and the properties of lipid bilayers .
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Cat. No.: HY-121527
CAS No.: 1300-94-3
Purity:  98.26%
Amylmetacresol is a phenolic compound with topical antibacterial and antiviral activity. Amylmetacresol works by destroying the protein structure of the virus surface or interfering with the function of the virus lipid membrane. Amylmetacresol inhibits the attachment and replication of respiratory viruses such as human Rhinovirus 1a and influenza virus A, without significant effect on viruses such as HRV8. Amylmetacresol is mainly applied topically to the throat to relieve viral sore throats. Amylmetacresol is more active against enveloped viruses than non-enveloped viruses .
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Cat. No.: HY-150163
CAS No.: 1309763-43-6
Purity:  99.00%
Target:  

Endogenous Metabolite

Research Areas:  

Metabolic Disease

RBM14C12 is a compound with cell signal transduction activity. RBM14C12 has important uses in studying lipid metabolism and cell membrane structure. RBM14C12 can also be used to develop novel compounds to regulate the biological mechanisms of lipid-related diseases.
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Cat. No.: HY-W009877
CAS No.: 92-91-1
4-Acetylbiphenyl (ACBP) is a biphenyl compound that can be used as a probe molecule to study the structure and function of proteins and to study the properties of lipid membranes .
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Cat. No.: HY-166257
CAS No.: 38621-58-8
Synonyms: Psychosine 3′-O-sulfate; Psychosine 3′-sulfate
Research Areas:  

Metabolic Disease

Lyso-sulfatide (bovine) is a phospholipid component derived from sphingolipid catabolism and a potent factor Xa inhibitor and anticoagulant. Lyso-sulfatide (bovine) binds directly to factor Xa and inhibits prothrombin activation mediated by the prothrombinase complex, thereby prolonging factor Xa-induced plasma clotting time and suppressing thrombin generation. Lyso-sulfatide (bovine) serves as a reliable lipid membrane mimic for studying cell membrane structure, function, and molecular interactions .
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